A5032635247- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Hormonal and reproductive studies
- Diabetes Management and Research
- Genetic factors in colorectal cancer
- Digestive system and related health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hormonal Regulation and Hypertension
- Sexual Differentiation and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peroxisome Proliferator-Activated Receptors
- Thyroid Disorders and Treatments
- Astronomy and Astrophysical Research
- Vaccine Coverage and Hesitancy
- Adolescent and Pediatric Healthcare
- Growth Hormone and Insulin-like Growth Factors
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Lymphocytic Leukemia Research
- Gamma-ray bursts and supernovae
- Stellar, planetary, and galactic studies
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
Çanakkale Onsekiz Mart Üniversitesi
2021-2024
Kayseri Eğitim ve Araştırma Hastanesi
2018-2020
Bursa Uludağ Üni̇versi̇tesi̇
2014-2017
Istanbul University
2014
Nationwide Study of Turner Syndrome ABS TRACTObjective: syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and genetic background affected girls.This study aimed to systematically investigate key TS in relationship large pediatric Turkish patient population.Methods: Our retrospective included 842 karyotype-proven patients aged 0-18 years who were evaluated 35 different centers Turkey...
Background Gut microbiota studies in the field of endocrinology metabolism have attracted increasing attention recent years. To comprehensively assess evolving landscape this research field, we conducted a thorough bibliometric analysis gut indexed Web Science database. Methods We collected and analyzed 3,339 original articles reviews published from 1972 to 2023. Using various indicators, investigated publication trends, country contributions, international collaborations, prolific authors,...
Summary Context Hypophosphataemic rickets (HR) is a group of rare hereditary renal phosphate wasting disorders caused by mutations in PHEX , FGF23 DMP1, ENPP1, CLCN5 or SLC34A3 . Objective To investigate underlying genetic defects patients with hypophosphataemic rickets. Methods We analysed genomic DNA from nine unrelated families for the entire coding region PCR sequencing and copy number analysis. Results A total 14 were studied. identified 12 seven families. Five them novel present eight...
The presence of pulsating stars in eclipsing binary systems (EBs) makes these objects significant since they allow us to investigate the stellar interior structure and evolution. Different types could be found EBs such as Delta Scuti variables. have been known for decades increasing number is important understanding pulsational structure. Hence, this study, a research was carried out on southern TESS field discover new EBs. We produced an algorithm search detached semi-detached considering...
Abstract Context There is a significant challenge of attributing specific diagnoses to patients with primary adrenal insufficiency unknown etiology other than congenital hyperplasia (non-CAH PAI). Specific per se may guide personalized treatment or illuminate pathophysiology. Objective This work aimed investigate the efficacy steroid hormone profiles and high-throughput sequencing methods in establishing non-CAH PAI origin. Methods Pediatric whose could not be established by clinical...
To evaluate the anthropometric features of girls with Turner syndrome (TS) at birth and presentation effect karyotype on these parameters. Data were collected from 842 patients TS 35 different centers, who followed-up between 1984 2014 whose diagnosis age ranged to 18 years. Of patients, 122 received growth hormone, estrogen or oxandrolone excluded, 720 included in study. In this cohort, frequency small for gestational (SGA) was 33%. The SGA 4.2% (2/48) preterm 36% (174/483) term neonates (P...
Abstract NARS2 mutations are known to cause various clinical phenotypes such as nonsyndromic hearing loss, Leigh/Alpers syndrome, refractory epilepsy, developmental delay, intellectual disability and myopathy. We presented the first Turkish variant of NASR2 added type 1 diabetes mellitus (DM), which was not previously described in phenotype spectrum this disease. A 4.5-month-old girl with hypotonia, myoclonic severe delay large subdural hemorrhage. In year follow-up, DM developed. homozygous...
Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and 2% of cases have familial origin. Our aim in this study was to determine genetic alterations two siblings with CH coming from a consanguineous family. Because often inherited autosomal recessive manner consanguineous/multicase-families, we first performed linkage studies all known causative loci followed by conventional sequencing linked gene. The family showed potential TSHR locus, detected an essential splice...
Children with Turner syndrome (TS) have a specific growth pattern that is quite different from of healthy children. Many countries population-specific charts for TS. Considering national and ethnic differences, we undertook this multicenter collaborative study to construct reference values height, weight body mass index (BMI) 3 years age adulthood spontaneous Turkish girls TS.Cross-sectional height data 842 patients TS, younger than 18 before starting any therapy, were evaluated.The...
Abetalipoproteinaemia (ABL) is an autosomal recessive disorder characterized by very low plasma concentrations of total cholesterol and triglyceride (TG).It results from mutations in the gene encoding microsomal TG transfer protein (MTTP).A nine-month-old girl was admitted to hospital because fever, cough, diarrhea failure thrive.She had levels according her age.The peripheral blood smear revealed acanthocytosis.Thyroid function test showed central hypothyroidism.Cranial magnetic resonance...
Introduction Vitamin D binding protein (VDBP) plays a crucial role in vitamin transport and metabolism. The rs4588-A polymorphism of the GC gene, encoding VDBP, has been associated with altered serum VDBP 25-hydroxyvitamin (25OHD) levels. However, mechanisms underlying these effects remain unclear. We aimed to investigate relationship between urinary excretion 25OHD levels individuals without allele. Methods A cross-sectional study was conducted on 109 children (mean age: 11.96 years)...
Background: Endocrine disorders in infants neonatal intensive care units (NICU) represent a significant clinical concern. Understanding the frequency and variety of these is crucial for effective patient management. Objectives: This single-center retrospective study was conducted to examine patterns endocrine among neonates NICU. Methods: We performed review 1 845 records over five years from NICU at Çanakkale Onsekiz Mart University Health Practice Research Hospital. The included patients...
Purpose: Obesity and vitamin D deficiency is a significant public health problem with increasing frequency in childhood. Although numerous studies explored the correlation between obesity D, study aimed to investigate such relationship consideration of few/no on body compositions obese people. Methods: A total 62 adolescents aged 12 18 were included study, comprising 33 29 normal weight. Blood samples analyzed for 25-hydroxyvitamin (25(OH)D), calcium (Ca), phosphorus (P), magnesium (Mg),...
Amaç: Bu çalışmanın amacı diyabet doğa kampının diyabetli çocuklarda yaşam kalitesi ve kontrolü üzerindeki etkisinin değerlendirmesi kalitesine etkili faktörlerin araştırılmasıdır. 
 Gereç Yöntemler: çalışmaya Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Çocuk Sağlığı Hastalıkları Endokrinoloji Bölümü’nde takip edilen, kamplarına katılmış olan olmayan tip 1 Diyabetes Mellitus (DM) tanılı çocuk adolesanlar dahil edilmiştir. Veriler, Diyabetli Çocuklar için Yaşam Kalitesi Ölçeği...
Abstract Background This study compared the effectiveness of traditional and revised one-bag protocols for pediatric diabetic ketoacidosis (DKA) management. Methods single-center retrospective cohort included children diagnosed with DKA upon admission between 2012 2019. Our institution reevaluated streamlined protocol (revised protocol). The rehydrated all patients dextrose (5 g/100 ml) containing 0.45% NaCl at a rate 3500 ml/m2 per 24 h after first 1 bolus normal saline, regardless age or...
Background. The aim of the study was to examine effect hyponatremia at admission as a negative prognostic factor in children hospitalized with COVID-19 pneumonia. Methods. data patients aged 1 month-18 years, who were followed diagnosis pneumonia Çanakkale Onsekiz Mart University Hospital, Department Pediatrics, between January 2018 and May 2021 examined, retrospectively. Patients (n=661) divided into two main groups; (n=158) other pneumonias [other viral (n=161) unknown etiology...
Amaç: Çanakkale ili ve çevresindeki Tip 1 Diyabetes Mellitus (DM) tanılı olguların demografik özelliklerinin, klinik laboratuvar bulgularının, başvuru anında diyabetik ketoasidoz (DKA) durumlarının aldıkları tedavilerin değerlendirilmesi amaçlanmıştır. Yöntem: Onsekiz Mart Üniversitesi Tıp Fakültesi Hastanesi Çocuk Sağlığı Hastalıkları kliniğine 01.04.2011-01.04.2019 tarihleri arasında en az bir kez başvurmuş 0-18 yaş arası, 165 DM hasta dosyası retrospektif tarandı. Dosya kayıtları eksik 68...
Özgün Araştırma
ÖzGiriş: Bu çalışmada, tip 1 diyabetli çocuğu olan ebeveynlerin çocuklarına COVID-19 aşısı yaptırmaya yönelik tutumlarını araştırmayı
The presence of pulsating stars in eclipsing binary systems (EBs) makes these objects significant since they allow us to investigate the stellar interior structure and evolution. Different types could be found EBs such as Delta Scuti variables. have been known for decades increasing number is important understanding pulsational structure. Hence, this study, a research was carried out on southern TESS field discover new EBs. We produced an algorithm search detached semi-detached considering...
Abstract Purpose: With weight gain and/or obesity, adipocytokine levels in the blood change and nonalcoholic fatty liver disease (NAFLD) develops. In this study, we aimed to evaluate how serum betatrophin homeostasis model assessment insulin resistance (HOMA-IR) are affected children receiving valproic acid (VPA) monotherapy whether shear wave elastography (SWE) accurately detects NAFLD these patients. Methods :Children aged 8-18 years with a diagnosis of epilepsy who received VPA for at...
Aim: Patients with type 1 diabetes mellitus (T1DM) are known to be more prone vitamin D deficiency. Vitamin studies in this
 patient population have traditionally been performed using serum 25OHD levels. However, binding protein (VDBP) has
 less studied. This study aims compare VDBP levels T1DM healthy controls. It also investigate the factors
 affecting such as disease duration, HbA1c, insulin dose, and age diabetic subjects.
 Material Methods: A research was conducted...