A5086670130- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hormonal and reproductive studies
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Hemoglobinopathies and Related Disorders
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Iron Metabolism and Disorders
- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Menstrual Health and Disorders
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Amyloidosis: Diagnosis, Treatment, Outcomes
Istanbul Medeniyet University
2018-2024
Uni Research (Norway)
2018
Gazi University
2009-2017
Ministry of Health
2017
Gazi Hastanesi
2015
Nationwide Study of Turner Syndrome ABS TRACTObjective: syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and genetic background affected girls.This study aimed to systematically investigate key TS in relationship large pediatric Turkish patient population.Methods: Our retrospective included 842 karyotype-proven patients aged 0-18 years who were evaluated 35 different centers Turkey...
More than 50 disease-associated mutations of the Mediterranean fever gene (MEFV) have been identified in familial (FMF), some which were shown to different clinical, diagnostic, prognostic, and therapeutic implications. The aim our study was define frequency mutation type, genotype-phenotype correlation, response colchicine treatment patients with FMF.This included 222 pediatric FMF patients. All investigated for 6 MEFV mutations. Then divided into 3 groups according presence M694V on both...
Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim the present study assess differences between PCOS age- body mass index (BMI)-matched controls determine possible factor(s) impacting psychological parameters Materials methods: included 80 50 BMI-matched...
Objectives To investigate the utility of shear wave elastography (SWE) in detecting morphologic abnormalities median nerve and posterior tibial transverse longitudinal axes adolescents with type 1 diabetes mellitus (DM) without diabetic peripheral neuropathy (DPN). Methods The nerves 25 diagnosis follow‐up DM DPN 32 healthy volunteers were evaluated SWE by 2 observers on axes. cross‐sectional area thickness disease duration noted, probable associations these parameters features analyzed....
What this study adds?What is already known on topic?Objective: The aim of the present was to document ovarian cyst frequency and characteristics as well distribution these parameters with respect age in children adolescents.Methods: We retrospectively analyzed medical records 1009 girls between ages 5-18 years who presented our pediatric emergency department (PED) pelvic pain therefore underwent ultrasound examination June 2011 May 2014.Results: In total, 132 (13.1%) were identified having...
Soluble endoglin (S-endoglin) has been implicated as a potential marker of endothelial dysfunction (ED) and was reported to be elevated in diabetic adults, correlating with the severity vasculopathy. However, circulating S-endoglin its association other markers ED have not formerly analyzed first decade diabetes onset adolescents type 1 mellitus (T1DM).Fifty-eight moderately/poorly controlled T1DM were included this study twenty-nine healthy served controls. The group divided into two groups...
Chronic abdominal pain (CAP) is one of the most common indications esophagogastroduodenoscopy (EGD) in pediatric population. However, there not enough information about diagnostic yield EGD children with CAP. We aimed to evaluate CAP Eastern Black Sea region Turkey.
<b><i>Background/Aims:</i></b> Congenital hyperinsulinism (CHI) denotes an inappropriate secretion of insulin from pancreatic β-cells in the presence a low blood glucose level due to various genetic causes. Diazoxide is first-line medical treatment for CHI. In case failure, somatostatin analogue called octreotide used. A prolonged QT interval unusual side effect which can be lethal if unrecognized. <b><i>Case Presentation:</i></b> We report on...
Objective: Infections remain the major cause of unnecessary antibiotic use in pediatric outpatient settings.Complete blood count (CBC) is essential test diagnosis infections.C-reactive protein (CRP) also useful for assessment young children with serious bacterial infections.The purpose study was to evaluate leukocyte populations and CRP level predict infections febrile children. Materials Methods:The values CBC by Cell-DYn 4000 autoanalyzer serum levels were evaluated 120 patients documented...
The aim of this study was to compare the nephrotoxicity risk cisplatin (CPL) and ifosfamide (IFO) combination treatment (CT) with that CPL alone evaluate prevalence CPL-induced long-term in pediatric cancer survivors (CS).A total 33 patients solid tumors who have been cured their disease were included study. They divided into two groups based on type chemotherapeutics, either (n = 21) or CT 12), given during evaluated for glomerular tubular function using Skinner grading...
Cardio-facio-cutaneous (CFC) syndrome is a rare disorder characterized by craniofacial dysmorphia, ectodermal abnormalities, cardiac malformations, as well growth and developmental delay. Although some endocrine abnormalities have been reported in this syndrome, very little known about CFC syndrome-related disorders. A 7.5-year-old boy was admitted to our endocrinology clinic with the complaint of short stature. He had height 103 cm [-4 standard deviation (SD)], weight 16 kg (<3(th)...
What this study adds?In context, AZFc gene deletion on peripheral blood lymphocytes DNA detected in our patient (Y-chromosomal microdeletion of the region) may contribute to germ cell tumour development as a risk factor.This can be expected when considering role AZF genes gonadal differentiation by providing Y-chromosome stability during early embryogenic development. is already knoWn topic?Patients with dysgenesis, particularly those carrying Y chromosomal material tissue, are at an...
Obesity in children appears to be associated with increased risk of cardiovascular and metabolic diseases later life. Early development insulin resistance (IR) may lead endothelial dysfunction carotid intima–media thickness (cIMT) even childhood. We compared cell-specific molecule-1 (endocan) levels pediatric obese patients those healthy controls determine whether endocan could used as a biological marker complications caused by damage. In 80 pubertal (44 males [M] 36 females [F], mean age:...
Abstract Context There is a significant challenge of attributing specific diagnoses to patients with primary adrenal insufficiency unknown etiology other than congenital hyperplasia (non-CAH PAI). Specific per se may guide personalized treatment or illuminate pathophysiology. Objective This work aimed investigate the efficacy steroid hormone profiles and high-throughput sequencing methods in establishing non-CAH PAI origin. Methods Pediatric whose could not be established by clinical...
Topical application of eye drops may cause mild or severe adverse ocular systemic effects. Children, particularly infants, are more prone to effects topical because their lower body mass and blood volume, immature metabolism, immaturity excretory, nervous, cardiovascular systems. Early recognition signs symptoms toxicity is very important. Most the can resolve spontaneously; however, in cases, physostigmine treatment be required. Respiratory distress a rare effect cyclopentolate. We report...
To evaluate the anthropometric features of girls with Turner syndrome (TS) at birth and presentation effect karyotype on these parameters. Data were collected from 842 patients TS 35 different centers, who followed-up between 1984 2014 whose diagnosis age ranged to 18 years. Of patients, 122 received growth hormone, estrogen or oxandrolone excluded, 720 included in study. In this cohort, frequency small for gestational (SGA) was 33%. The SGA 4.2% (2/48) preterm 36% (174/483) term neonates (P...
The mRNA-based BNT162b2 (Pfizer-BioNTech) vaccine has been shown to elicit robust systemic immune response and confer substantial protection against the severe coronavirus disease (COVID-19), with a favorable safety profile in adolescents. However, no data exist regarding immunogenicity, reactogenicity clinical outcomes of COVID-19 vaccines adolescents type 1 diabetes (T1D). In this prospective observational cohort study, we examined humoral responses side effects induced by vaccine, as well...
The prevalence of non-alcoholic fatty liver disease in children has risen significantly, owing to the worldwide childhood obesity epidemic last two decades. Non-alcoholic is closely linked sedentary lifestyle, increased body mass index, and visceral adiposity. In addition, individual genetic variations also have a role development progression disease. aim this study was investigate gene polymorphisms MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 (rs4149313), IL-17A...
Several studies have been performed concerning pathologies of the stomach and esophagus in pediatric age group. However, there very few duodenal children. The authors aimed to examine clinical, endoscopic, histopathological characteristics, as well etiology Patients aged between 1 17 years undergoing esophagogastroduodenoscopy during two at this unit, were investigated retrospectively. Demographic, endoscopic data, presence pathologies, gastritis, esophagitis recorded all Out 747 children...
To evaluate neural and vascular retinal morphology of children with isolated growth hormone deficiency (GHD) to determine any changes due GH treatment.Twenty-eight GHD 53 age-, gender- body mass index-matched healthy volunteers were enrolled in this prospective study. The nerve fibre layer (RNFL) macular thickness (MT) measured, as well intraocular pressure (IOP). number branching points calculated. Effect treatment on the retina IOP was evaluated after one year treatment. Measurements also...
Children with Turner syndrome (TS) have a specific growth pattern that is quite different from of healthy children. Many countries population-specific charts for TS. Considering national and ethnic differences, we undertook this multicenter collaborative study to construct reference values height, weight body mass index (BMI) 3 years age adulthood spontaneous Turkish girls TS.Cross-sectional height data 842 patients TS, younger than 18 before starting any therapy, were evaluated.The...