A5075879409- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Sepsis Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Platelet Disorders and Treatments
- Respiratory Support and Mechanisms
- EEG and Brain-Computer Interfaces
- Blood properties and coagulation
- Neurological disorders and treatments
- Vascular Malformations Diagnosis and Treatment
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Cholesterol and Lipid Metabolism
- Epilepsy research and treatment
- Long-Term Effects of COVID-19
- Hemostasis and retained surgical items
- Airway Management and Intubation Techniques
- Moyamoya disease diagnosis and treatment
- Vagus Nerve Stimulation Research
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy and preeclampsia studies
- Hematological disorders and diagnostics
- Neurological Complications and Syndromes
- Venous Thromboembolism Diagnosis and Management
Beaumont Hospital
2019-2024
Botsford Hospital
2024
Beaumont Hospital, Dearborn
2024
Christ University
2024
Trinity College Dublin
2016-2018
St. James's Hospital
2016-2018
Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory characteristics are incompletely understood.Objectives: To define the cytokine profile of COVID-19 and identify evidence immunometabolic alterations in those with severe illness.Methods: Levels IL-1β, IL-6, IL-8, IL-10, sTNFR1 (soluble tumor necrosis factor receptor 1) were assessed plasma from healthy volunteers, hospitalized but stable patients (COVIDstable patients), requiring ICU admission (COVIDICU...
The development of thrombocytopenia in sepsis is a poor prognostic indicator associated with significantly increased mortality risk. Mechanisms underlying this phenomenon remain to be clearly elucidated. Matrix metalloproteinases (MMPs) are enzymes that regulate the turnover extra-cellular matrix. MMP-2 recognised as platelet agonist MMP-9 proposed an inhibitor activation. existence platelets subject debate. There limited evidence thus far suggest toll-like receptor 4 (TLR-4) and...
Vagus nerve stimulation is a well-established treatment option for patients with drug-resistant epilepsy and has an expanding range of other clinical indications. Side effects vagus therapy include: cough; voice changes; vocal cord adduction; rarely, obstructive sleep apnoea; arrhythmia. Patients implanted devices may present unrelated surgery critical care to clinicians who are unfamiliar their function safe management. These guidelines have been formulated by multidisciplinary consensus...
Abstract Background Delayed cerebral ischemia (DCI) is the leading cause of adverse outcome in patients who survive initial phase subarachnoid hemorrhage (SAH). While guidelines recommend induced hypertension as a first-line treatment for DCI, there no high-level evidence confirming benefit. Methods Patients admitted with nontraumatic SAH over 3 years period were identified. Demographics, clinical/radiological presentation, aneurysm repair method, and Glasgow score (GOS) months postdischarge...
Antiplatelet therapies remain an area of potential interest for the treatment sepsis; however, studies platelet aggregation in sepsis have yielded conflicting results. We examined patterns patients with septic shock using quartz crystal microbalance dissipation technology, a microfluidic device capable measuring microaggregate formation under flow conditions. Platelet was increased washed samples patients. Conversely, these same platelets aggregated less than healthy controls when their plasma.
Abstract Background Decompressive craniectomies (DCs) are recommended for the treatment of refractory raised intracranial pressure following acute ischaemic stroke. Some studies have demonstrated improved survival and functional outcomes post early decompressive craniectomy (<48 hours from ictus) in patients who developed malignant cerebral oedema middle artery infarction. Limited data is available on role suboccipital cerebellar Objective Our primary objective was to determine whether...
In this case report, we detail the anesthetic management of a patient with Giant Bullous Emphysema (GBE) secondary to smoking undergoing craniotomy for posterior fossa lesion in prone position, head immobilization using skull pins. GBE poses significant challenges due compromised lung function and risk bullae rupture. With impracticality spontaneous ventilation owing surgical positioning duration surgery, our approach prioritized meticulous control permissive hypercapnia striking balance...
The global demand for hospital care, driven by population growth and medical advances, emphasizes the importance of optimized resource management. Enhanced Recovery After Surgery (ERAS) protocols aim to expedite patient recovery reduce health care costs without compromising safety or satisfaction. Its principles have been adopted in various surgical specialties but not fully encompassed all areas neurosurgery, including craniotomy. ERAS craniotomy has shown length stay increasing...
Abstract Peripartum cerebral angiopathy (PCA) is a rare cerebrovascular disorder of unclear etiology that typically occurs in the first postpartum week. The aim this case series to present seven cases PCA and associated outcomes. Two were typical reversible vasoconstriction syndrome (RCVS) had no long-term sequelae. Five involved intraparenchymal hemorrhage absence an underlying vascular lesion, with three five having vasoconstriction. None patients documented history preeclampsia or...