A5020410353- Research on Leishmaniasis Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- interferon and immune responses
- Influenza Virus Research Studies
- Escherichia coli research studies
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Trypanosoma species research and implications
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Autoimmune Neurological Disorders and Treatments
- Vaccine Coverage and Hesitancy
- Herpesvirus Infections and Treatments
- Housing, Finance, and Neoliberalism
- Vitamin D Research Studies
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Toxin Mechanisms and Immunotoxins
- Glycosylation and Glycoproteins Research
- Blood Coagulation and Thrombosis Mechanisms
Roslin Institute
2016-2024
University of Edinburgh
2014-2024
Edinburgh College
2020
Trinity College Dublin
2015-2016
University of Glasgow
2009-2012
University of Strathclyde
2008-2011
Wellcome Centre for Molecular Parasitology
2009
Johns Hopkins Hospital
2004
Maryland Department of Health
2004
Papua New Guinea Institute of Medical Research
1977
Avian pathogenic Escherichia coli (APEC) cause severe respiratory and systemic disease in chickens, commonly termed colibacillosis. Early immune responses after initial infection are highly important for the outcome of infection. In this study, early interactions between GFP-expressing APEC strains serotypes O1:K1:H7 O2:K1:H5 phagocytic cells lung CSF1R-reporter transgenic chickens were investigated. express fluorescent protein under control elements CSF1R promoter enhancer, such that...
The avian respiratory tract is a common entry route for many pathogens and an important delivery vaccination in the poultry industry. Immune responses lung have mostly been studied vivo due to lack of robust, relevant vitro ex models mimicking microenvironment. Precision-cut slices (PCLS) major advantages maintaining 3-dimensional architecture includes heterogeneous cell populations. PCLS obtained from number mammalian species chicken embryos. However, as embryonic physiologically...
Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated a biased Th2 response while similarly IL-4Rα-deficient fail to and robust Th1 response. In order determine the functional target(s) for IL-4/IL-13 inducing disease, course of L. infection was monitored in lacking IL-4Rα expression specific cellular compartments. A deficiency on macrophages/neutrophils (in LysMcreIL-4Rα−/lox animals) had minimal effect outcome...
Evidence suggests that susceptibility to avian influenza A virus in chickens is influenced by host genetics, but the mechanisms are poorly understood. previous study demonstrated inbred line 0 more resistant low-pathogenicity (LPAI) infection than CB.12 birds based on viral shedding, resistance was not associated with higher AIV-specific IFNγ responses or antibody titres. In this study, we investigated proportions and cytotoxic capacity of T-cell subpopulations spleen early immune...
ABSTRACT Leishmania mexicana cysteine peptidases (CPs) have been identified as important parasite virulence factors. More recently, a natural inhibitor of CPs (ICP) from L. has characterized, and ICP mutants created. Infection BALB/c mice with null or reexpressing resulted in nonhealing, progressively growing lesions albeit slightly attenuated compared the growth produced by wild-type parasites. In contrast, infected overexpressing were able to significantly control lesion heal. While...
The respiratory tract is a key organ for many avian pathogens as well major route vaccination in the poultry industry. To improve immune responses after of chickens through increased uptake vaccines and targeting to antigen presenting cells, better understanding system required. Transgenic MacReporter birds were used expressing reporter gene (eGFP or mApple) under control CSF1R promoter enhancer cells mononuclear phagocyte (MNP) lineage visualize ontogeny lymphoid tissue, macrophages...
The major histocompatibility complex (MHC) region contains many genes that are key regulators of both innate and adaptive immunity including the polymorphic MHCI MHCII genes. Consequently, characterisation repertoire MHC is critical to understanding variation determines nature immune responses. Our current knowledge bovine limited with only Holstein-Friesian breed having been studied in any depth. Traditional methods genotyping low resolution laborious this has a impediment more...
Despite the recent advances in our understanding of dynamics cellular interactions associated with induction immune responses, comparatively little is known about vivo behaviour antigen-experienced T cells upon secondary antigen exposure either priming or tolerance. Such information would provide an insight into functional mechanisms employed by memory distinct phenotypes and invaluable knowledge how a specific tolerogenic immunogenic state maintained. Using real-time imaging to follow...
Avian pathogenic E. coli (APEC) cause severe respiratory and systemic disease. To address the genetic immunological basis of resistance, inbred chicken lines were used to establish a model differential resistance APEC, using strain O1 serotype O1:K1:H7. Inbred 72, 15I C.B12 outbred line Novogen Brown inoculated via airsac with high dose (107 colony-forming units, CFU) or low (105 APEC O1. Clinical signs, colibacillosis lesion score bacterial colonization tissues after challenge significantly...
Infections with persistent or latent viruses alter host immune homeostasis and have potential to affect the outcome of concomitant acute viral infections such as influenza A virus (IAV). Gammaherpesviruses establish life-long require an on-going response control reactivation. We used a murine model co-infection investigate IAV infection in mice latently infected gammaherpesvirus MHV-68. Over course infection, BALB/c showed less weight loss, clinical signs, pulmonary cellular infiltration...
The need for integrated pathways and shared data across organisations is not in doubt if services are to reduce risk health wellbeing, maintain independence contain escalating social care costs. However, there three challenges achieving this. first how connect the that matters different systems. second make this useful front line carers system planners while staying within strict boundaries of protection confidentiality. third securing citizen consent do Where chancellor has just announced...