A5019924367- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Immune cells in cancer
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Chemotherapy-induced organ toxicity mitigation
- Inflammasome and immune disorders
- Neurogenetic and Muscular Disorders Research
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Acute Kidney Injury Research
- Natural product bioactivities and synthesis
- Cardiac Fibrosis and Remodeling
- Genetic Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Botulinum Toxin and Related Neurological Disorders
- Endoplasmic Reticulum Stress and Disease
- Spinal Hematomas and Complications
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Gout, Hyperuricemia, Uric Acid
- Metabolism and Genetic Disorders
- Toxin Mechanisms and Immunotoxins
Jiangxi University of Traditional Chinese Medicine
2013-2024
Temple University
2023-2024
Central South University
2010-2023
Second Xiangya Hospital of Central South University
2020-2023
Hubei University of Chinese Medicine
2020-2021
People's Hospital of Cangzhou
2021
Xiangya Hospital Central South University
2010-2020
Ann Arbor Center for Independent Living
2020
Chongqing Technology and Business University
2020
State Key Laboratory of Food Science and Technology
2020
Our study aimed to explore associations between microRNA-21 (miR-21) and PTEN/PI3K/AKT signaling pathway and, further, elucidate the regulation of miR-21 on biological behaviors in human esophageal cancer cells. The expressions miR-21, PTEN, PI3K, AKT were detected 89 samples 58 adjacent normal tissues respectively. cells (TE11) grouped as following: blank (TE11 without transfection), negative with inhibitor), Inhibition-miR21 inhibitor). Western blot was used for detection P13K, protein...
Inflammation is a complex physiological process that poses serious threat to people's health. However, the potential molecular mechanisms of inflammation are still not clear. Moreover, there lack effective anti-inflammatory drugs meet clinical requirement. Procyanidin A1 (PCA1) monomer component isolated from and shows various pharmacological activities. This study further demonstrated regulatory role PCA1 on lipopolysaccharide (LPS)-stimulated inflammatory response oxidative stress in...
Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, its potential mechanism of protective effects remains unclear. In this study, the HKL on LPS-induced ALI was explored in vivo and vitro.In vivo, SD rats were intratracheally instilled with LPS (5 mg/kg) establish an model then treated (1.25/2.5/5 or ML385 (30 intraperitoneally. vitro, human bronchial epithelial cell line (BEAS-2B) stimulated ATP induce pyroptosis (12.5/25/50 μM)....
To investigate the potential applications and molecular mechanisms of transcranial direct current stimulation (tDCS) on cognitive impairment in a vascular dementia (VD) animal model. Sprague-Dawley rats were used this study. VD rat model was induced by modified permanent bilateral common carotid artery occlusion (2-VO) approach. Anodal tDCS applied to animals. Morris water maze analyze spatial memory navigation ability. The pathological changes hippocampal CA1 region cerebral cortex examined...
Anemoside B4 (B4) isolated from Radix Pulsatilla has anti-inflammatory activities in the colon and antitumor effects. However, its role prevention treatment of kidney injury not been reported. Here, we reported effects on chronic (CKI) studied related mechanism based an adenine-induced model rats. The results showed that serum BUN (blood urea nitrogen), Crea (creatinine), urinary proteins increased significantly after oral administration adenine. Meanwhile, adenine contents both renal tissue...
Abstract Restenosis caused by neointimal hyperplasia significantly decreases long-term efficacy of percutaneous transluminal angioplasty (PTA), stenting, and by-pass surgery for managing coronary peripheral arterial diseases. A major cause pathological neointima formation is abnormal vascular smooth muscle cell (VSMC) proliferation migration. Notoginsenoside R1 (NGR1) a novel saponin that derived from Panax notoginseng has reported cardioprotective, neuroprotective anti-inflammatory effects....
Abstract Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic (BDNF), neuronal plasticity. However, regulation proteomic profiles in neurons suffering CORT remaining elusive. Thus, mouse C17.2 stem cells were comprehensively investigated by TMT (tandem mass tag)-labeling quantitative proteomics. The proteomics conjugated gene ontology analysis revealed inhibitory effect on...
Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that a protective effect on hyperuricaemia.This study investigates the of cortex ethanol extract (EU) hyperuricaemia and explores underlying mechanism in Kunming mice Sprague-Dawley rats.Sixty sixty rats were divided into normal control, hyperuricaemia, allopurinol (10 mg/kg) three EU groups. The groups received intragastric at 80, 160, 320 mg/kg 100, 200, 400 for 7 days. Serum uric acid...
Context α-Hederin, a potent bioactive compound of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), has many pharmacological uses, but its effect on cancer cell metabolism is still unclear.Objective To elucidate the role α-hederin in glucose lung cells.Materials and methods Cell Counting Kit 8 colony formation assays were employed to assess antiproliferative effects α-hederin. Glucose uptake, ATP generation, lactate production measured. Glycolysis-related proteins detected using western...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign of antineoplastic agents on the basis 2-phenylnaphthalene-type structural pattern. 2. Synthesis and biological activity studies benzo[b]naphtho[2,3-d]furan-6,11-dione derivativesC. C. Cheng, Qing Dong, Dun Fu Liu, Yi Lin Luo, Leroy F. Allan Y. Chen, Chiang Yu, Niramol Savaraj, Ting Chao ChouCite this: J. Med. Chem. 1993, 36, 25, 4108–4112Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue...
Context: Lipopolysaccharide (LPS) is often used to induce immunoinflammatory reactions. TLR4/NFκB and NLRP3 signalling are major factors for inflammation. Dexamethasone (DXM) has an anti-immunoinflammatory effect. Objective: To investigate the inflammatory reaction in pathological changes of organs expression during LPS infection. Materials methods: ICR mice were divided into control group (n = 9), 15) + DXM 14). (10 mg/kg) was injected intravenously group, normal saline group; (0.5 given by...
This study tried to explore whether corilagin would ameliorate or reverse the atherosclerotic development via toll-like receptor 4 (TLR4) signaling pathway in vitro and vivo. Ana-1 cells Mouse Peritoneal Macrophages (MPMs) were stimulated with ox-LDL followed by treating gradient of concentration. TLR4 expression was up-regulated lentiviral transduction down-regulated siRNA. Peripheral blood mononuclear (PBMCs), plasma samples femoral arteries collected from rat peripheral artery disease...
Hereditary spastic paraplegias ( HSPs ) encompass a clinically and genetically heterogeneous group of neurodegenerative disorders. Recently, mutations in fatty acid 2‐hydroxylase gene FA2H have been identified responsible for type 35 SPG35 ). This study aims to define the contribution Chinese autosomal recessive HSP AR ‐ patients provide insights into enzymatic functions novel mutations. Direct sequencing was conducted 31 AR‐HSP families 55 sporadic cases without SPG11 , SPG15 SPG5 SPG7...
Abstract: Latifolin, one of the major flavonoids extracted from lignum dalbergiae odoriferae , has been documented to protect heart acute myocardial ischemia induced by pituitrin and isoproterenol in rats also found inhibit inflammation. In this study, we aimed investigate whether latifolin could doxorubicin (DOX)-induced cardiotoxicity elucidate its underlying mechanisms. Male mice were treated with an intraperitoneal dose DOX (20 mg/kg) plus oral at a 50 or 100 mg/kg for 12 days. After...
Context The Traditional Chinese herb medicine Dalbergia odorifera T. Chen (Fabaceae), exerted a protective effect on myocardial ischaemia. Latifolin is neoflavonoid extracted from odorifera. It has been reported to have the effects of anti-inflammation and cardiomyocyte protection.Objective To investigate whether latifolin can improve infarction (MI) through attenuating inflammatory explore its possible mechanisms.Materials methods Left coronary artery was ligated induce rat model MI, rats...
<b><i>Background:</i></b> Hereditary spastic paraplegias constitute a heterogeneous group of inherited neurodegenerative disorders. To date, there has been no systematic mutation and clinical analysis for large autosomal-dominant hereditary in China. <b><i>Objective:</i></b> The purpose this study was to investigate the frequencies phenotypes Chinese paraplegia patients. <b><i>Methods:</i></b> Direct sequencing multiplex...
Context Pulsatilla chinensis (Bunge) Regel (Ranunculaceae) possess antitumour effects; however, its potential has not been extensively investigated.Objective To investigate the synergetic effect of multi-components from P. induced cell apoptosis and explore mechanism.Materials methods The cytotoxicity was measured against NCI-H460, SMMC-7721, HCT-116 U251 lines treated with eight monomers chinensis. a combination saponin D (PSD), Raddeanoside R13 (R13), A (PSA) assessed using CalcuSyn3.0....