A5100761826- Chemokine receptors and signaling
- interferon and immune responses
- Thyroid Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Spinal Cord Injury Research
- Head and Neck Anomalies
- Multiple Sclerosis Research Studies
- Herpesvirus Infections and Treatments
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Microscopic Colitis
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Ion channel regulation and function
- Barrier Structure and Function Studies
- Spaceflight effects on biology
- Immune Cell Function and Interaction
- Thyroid and Parathyroid Surgery
Sichuan University
2023-2024
West China Hospital of Sichuan University
2023-2024
Shandong First Medical University
2020-2021
Changzhou Third People's Hospital
2021
Changzhou University
2021
Heze University
2019
Mudanjiang Medical University
2017
Cheng Shin Rubber (Taiwan)
2012
Cleveland Clinic
1999-2008
Abstract The inflammatory response initiated after spinal cord injury (SCI) is characterized by the accumulation of macrophages at impact site. Monocyte chemoattractant protein‐1 (MCP‐1) a strong candidate for mediating chemotaxis monocytes to injured nervous system. To help in defining role MCP‐1 inflammation SCI, we evaluated time course macrophage 2 weeks following midthoracic contusion mice lacking CCR2, principal receptor MCP‐1. Mice with deletion CCR2 resulted significantly reduced...
We evaluated the role of interleukin-6 (IL-6) in neuronal injury after CNS infection. IL-6-/- and IL-6+/+ mice resistant major histocompatibility complex (MHC) H-2b haplotype intracerebrally infected with Theiler's virus cleared infection normally without development viral persistence, lethal infection, or late phase demyelination. In contrast, on a susceptible H-2q resulted frequent deaths severe neurologic deficits within 2 weeks as compared littermate controls. Morphologic analysis...
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. A recent study identified 4 patterns demyelination in active MS lesions. The characteristics pattern II lesions suggested a primary mechanism myelin injury, while III showed features consistent with dying-back oligodendrogliopathy. recruitment, differentiation, and activation mononuclear phagocytes are dependent on expression chemokine receptors. Using immunohistochemistry we quantified cellular CCR1 CCR5 (n = 21)...
Abstract After injury in the adult central nervous system, invading and intrinsic cells contribute to formation of a lesion site that is refractory axonal growth. To test hypothesis inflammatory response trauma dictates extent growth after spinal cord injury, time course evolution was compared two mouse strains with contrasting cellular responses peripheral challenge. Adult C57Bl/6 129X1/SvJ mice received identical contusion injuries mid‐thoracic were allowed recover for 6 hours 9 weeks....
Follicular thyroid carcinoma (FTC), the second most prevalent cancer after papillary (PTC), tends to metastasize distantly, leading poorer outcomes. Despite substantial research, a holistic bibliometric analysis of FTC literature is lacking. This study aims fill this gap by employing methods track research evolution. English publications were systematically gathered from Web Science. Bibliometric analysis, using R, VOSviewer, CiteSpace, and Excel, synthesized data explored global trends...
The neurotrophic cytokines ciliary factor and leukemia inhibitory (LIF) play a key role in neuronal oligodendrocyte survival as protective factors neuroinflammation. To further elucidate the potential of endogenous LIF modulating neuroinflammation, we studied myelin glycoprotein-induced experimental autoimmune encephalomyelitis knockout mice (LIF(-/-) mice). In late phase active encephalomyelitis, LIF(-/-) exhibited markedly milder disease course. inflammatory infiltrate was characterized by...
Haematogenous leucocytes enter the central nervous system (CNS) during diverse disorders of varied aetiologies. Understanding trafficking cues that mediate CNS leucocyte infiltration might promote development flexible and selective means to modulate inflammation achieve clinical benefit. The machinery has been elucidated past decade consists cell-surface adhesion molecules, chemoattractant cytokines (chemokines) their receptors. Recent work in our laboratory characterized chemokine receptors...
ABSTRACT During the first 45 days after intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV), levels of mRNAs encoding chemokines MCP-1/CCL2, RANTES/CCL5, and IP-10/CXCL10 in central nervous system (CNS) are closely related to sites gene expression tissue inflammation. In present study, these were monitored during latter 135 a 6-month course TMEV-induced disease susceptible (PLJ) or resistant (C57BL/6) mice that possessed lacked either CD4 + CD8 T cells. These data...
Virus infection of the central nervous system (CNS) often results in chemokine upregulation. Although associated with lymphocyte recruitment, increased expression is also non-lymphocyte-mediated CNS disease. In these instances, effect upregulation on neurological disease unclear. vitro, several chemokines including monocyte chemotactic protein 1 (MCP-1) protect neurons from apoptosis. Therefore, vivo, may be a protective host response to damage. Alternatively, contribute pathogenesis by...
The role of focal brain damage as a trigger for autoimmune inflammation in multiple sclerosis (MS) is unclear. In this study we examine mechanisms by which experimental encephalomyelitis (EAE) enhanced damage. EAE was produced Lewis rats footpad inoculation; damage, the form cortical cryolesion (cryolesion-EAE), induced 8 days post-inoculation (d.p.i.). distribution and chemokine production cryolesion-EAE EAE-only were compared. Inflammation brain, measured immunocytochemistry T lymphocytes...
Abstract Chemokines and chemokine receptors are important regulators of leukocyte trafficking immune response. It is well established that chemokines their also expressed in the central nervous system (CNS), where expression has been associated with various neuroinflammatory diseases, such as multiple sclerosis (MS). One most involved MS pathology CCL2 (previously known MCP‐1). CCL2, released by glial cells, activates receptor CCR2, causing infiltration blood monocytes tissues affected MS....
The occurrence of cervical lymph node metastasis in T1 stage papillary thyroid carcinoma (PTC) is frequently observed. Notably, lateral (LLNM) emerges as a critical risk factor adversely affecting prognostic outcomes PTC. primary aim this investigation was to delineate the factors associated with LLNM initial stages
The β-R1/I-TAC (interferon-inducible T-cell α-chemoattractant) gene encodes an α-chemokine that is a potent chemoattractant for activated T-cells. We previously reported β-R1 was selectively induced by interferon (IFN)-β compared with IFN-α and the canonical type I IFN transcription factor interferon-stimulated 3 (ISGF3) necessary but not sufficient forβ-R1 induction IFN-β. These findings suggested IFN-β required accessory component. To begin characterizing this signaling pathway, we...
ABSTRACT Monocyte chemoattractant protein (MCP)‐1 is expressed by astrocytes in diverse inflammatory states and a key regulator of monocyte recruitment to the central nervous system (CNS). In current study, we addressed mechanisms which transcription human MCP‐1 gene (hMCP‐1) was terminated, after induction interferon (IFN)‐γ. Our results demonstrated that IFN‐γ‐induced hMCP‐1 followed refractory state, during resistant restimulation either IFN‐γ or heterologous activators such as TNF‐α....
The antiviral therapy has been considered as an ordinary intervention for COVID-19 patients. However, the effectiveness of is uncertain. This study was designed to determine association between and in-hospital mortality among severe patients.This enrolled patients admitted four designated hospitals in Wuhan, China. use treatments, demographics, laboratory variables, co-morbidities, complications, other treatments were compared survival fatal cases. agents analyzed.In total, 109 (mean age...
Background: Night-shift workers are exposed to nocturnal light and more prone develop circadian rhythm disorders. Although night-shift work is thought be associated with decreasing levels of melatonin, studies have showed inconsistent results. Methods: This systematic review meta-analysis studied the association between melatonin its metabolite, 6-sulfatoxymelatonin (aMT6s). PubMed EMBASE databases were searched up August 30, 2019. The difference in day was statistically quantified by...
Endoscopic thyroidectomy (ET) has witnessed significant advancements over the last three decades. Various surgical methods and approaches have been developed that minimize trauma, enhance aesthetics, reduce psychological stress caused by scars. Papillary thyroid carcinoma is main reason for ET represents an innovative technique treating cancer. In this study, nearly decades of scientific articles were analyzed summarized to gain a better understanding using bibliometric method.A total 486...