A5024312719- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Parathyroid Disorders and Treatments
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Nutrition, Genetics, and Disease
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Tumors and Oncological Cases
- Salivary Gland Tumors Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Bone health and osteoporosis research
- 14-3-3 protein interactions
- Molecular Biology Techniques and Applications
- BRCA gene mutations in cancer
Sichuan University
2021-2025
West China Hospital of Sichuan University
2021-2025
State Key Laboratory of Biotherapy
2021
Zhongnan Hospital of Wuhan University
2013-2017
Wuhan University
2013-2017
Fujian Medical University
2016
Putian University
2016
First Affiliated Hospital of Dalian Medical University
2014
Dalian Medical University
2014
Medullary thyroid cancer (MTC) represents 13.4 % of all cancers-related deaths. The treatments for MTC are very limited especially patients with distal metastasis. Therefore, it is critical to understand the mechanisms pursue novel therapeutic avenues. Here, we studied function circPVT1/miR-455-5p in MTC.Human tissues and cell lines were used. qRT-PCR Western blotting employed measure expression levels miR-455-5p, circPVT1, CXCL12, epithelial mesenchymal transformation (EMT)-related...
The interplay between sleep physiology and endocrine regulation has been well-established, with the thyroid gland, as a key organ, demonstrating physiologically plausible. Previous studies have indicated potential correlation factors diseases, yet causality remains uncertain. Given complex of confounders associated disorders lifestyle factors, we employed two-sample Mendelian randomization (MR) approach to minimize confounding bias rigorously investigate causal relationship. specific...
Abstract Context It is unclear whether radioactive iodine (RAI) therapy could improve cancer-specific survival (CSS) in patients with Hürthle cell carcinoma (HCC) of the thyroid. Objective To investigate effect RAI on CSS HCC patients. Methods who underwent total thyroidectomy (TT) were identified from Surveillance, Epidemiology, and End Results (SEER) database between 2000 2018. The Kaplan-Meier method Cox proportional hazards regression model used to evaluate CSS. Propensity score–matched...
Follicular thyroid carcinoma (FTC), the second most prevalent cancer after papillary (PTC), tends to metastasize distantly, leading poorer outcomes. Despite substantial research, a holistic bibliometric analysis of FTC literature is lacking. This study aims fill this gap by employing methods track research evolution. English publications were systematically gathered from Web Science. Bibliometric analysis, using R, VOSviewer, CiteSpace, and Excel, synthesized data explored global trends...
Abstract Context Radioactive iodine (RAI) therapy is often used as an adjuvant treatment to reduce the risk of recurrence in patients with papillary thyroid cancer (PTC). However, effect RAI on cancer-specific survival (CSS) tall cell variant (TCV) remains controversial. Objective This study aimed investigate impact CSS TCV-PTC by analyzing data from Surveillance, Epidemiology, and End Results database. Methods We identified 1281 SEER database who underwent total thyroidectomy between 2004...
The occurrence of cervical lymph node metastasis in T1 stage papillary thyroid carcinoma (PTC) is frequently observed. Notably, lateral (LLNM) emerges as a critical risk factor adversely affecting prognostic outcomes PTC. primary aim this investigation was to delineate the factors associated with LLNM initial stages
LINC00152 (long intergenic non-protein coding RNA 152) was identified as an oncogenic lncRNA in multiple cancers. In the current study, we aimed to explore transcriptional profile of oral squamous cell carcinoma (OSCC) and its regulations at level.Bioinformatic analysis performed by extracting OSCC subset from The Cancer Genome Atlas (TCGA)-Head Neck Squamous Cell Carcinoma (HNSC). subcellular localization interacting factors (TFs) were explored. Dual-luciferase assay ChIP-qPCR applied study...
Lymph node metastasis is widespread in papillary thyroid cancer (PTC). Patients are more vulnerable than those with central lymph if they have lateral neck (LLNM). There few researches focus on the correlation between clinical characteristics and genetic profile of PTC LLNM. In this study, we aimed to analyze features LLNM.A total 160 primary tumor samples derived from patients LLNM were involved. Targeted next-generation sequencing was carried out all 57 known thyroid-cancer-related genes....
Abstract Besides its well‐known benefits on human health, calcitriol, the hormonally active form of vitamin D 3 , has been being evaluated in clinical trials as an anticancer agent. However, currently available results are contradictory and not fundamentally deciphered. To best our knowledge, hypercalcemia caused by high‐dose calcitriol administration low bioavailability limit investigations translations. Here, we show that one‐step self‐assembly amphiphilic cholesterol‐based conjugates...
The correlation of genetic polymorphisms GALNT3 and vitamin D receptor (VDR) with osteoporosis in postmenopausal women was investigated. A total 1,212 cases patients diagnosed (observation group) 404 without (control were selected. Dual‑energy X‑ray absorptiometry used for measurement bone mineral density (BMD) lumbar vertebrae L2‑4, proximal femoral neck hip, classifications made. TaqMan genotyping technology employed to examine tag single-nucleotide polymorphism (tagSNP) VDR the tagSNP...
Abstract Immune checkpoint blockade has dramatically altered the concept of cancer therapeutics over past few years. Beyond existing classical pathways, novel immune checkpoints, such as T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif (ITIM) structural domain (TIGIT), have also emerged in recent years promising therapeutic potential. Recent researches provided ample evidence that TIGIT is extensively involved various cancerous noncancerous diseases chronic...
Abstract Background Whether radioactive iodine (RAI) therapy is effective in improving disease‐specific survival (DSS) patients with follicular variant papillary thyroid cancer (FVPTC) without distant metastasis remains unclear. Methods Patients FVPTC were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 2015. The Kaplan–Meier method Cox proportional hazards regression model used to evaluate DSS. Propensity score‐matched analysis was performed...
Objective To establish a human lung adenocarcinoma A549 cell line with RNA interference for YB-1 gene silencing which can stably express green fluorescent protein (GFP) and to observe the effects of Y-box binding (YB-1) on proliferation in cells.Methods The cells were transfected shRNA plasmid specific gene,and then selected through G418.G418-resistant clones generated screened using reverse transcription polymerase chain reaction (RT-PCR),real-time quantitative (FQ-PCR) Western blotting...