A5041175941- Air Quality and Health Impacts
- Atmospheric chemistry and aerosols
- Indoor Air Quality and Microbial Exposure
- Energy and Environment Impacts
- Air Quality Monitoring and Forecasting
- Fiber-reinforced polymer composites
- Climate Change and Health Impacts
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Inhalation and Respiratory Drug Delivery
- Toxic Organic Pollutants Impact
- Nanoparticles: synthesis and applications
- Maritime Transport Emissions and Efficiency
- Graphene and Nanomaterials Applications
- Recycling and Waste Management Techniques
- Occupational and environmental lung diseases
- Graphite, nuclear technology, radiation studies
- Mesenchymal stem cell research
- Polymer crystallization and properties
- Microplastics and Plastic Pollution
Helmholtz Zentrum München
2022-2024
University of Rostock
2022-2024
Imaging Center
2023
Background: Secondary organic aerosols (SOAs) formed from anthropogenic or biogenic gaseous precursors in the atmosphere substantially contribute to ambient fine particulate matter [PM ≤2.5μm aerodynamic diameter (PM2.5)] burden, which has been associated with adverse human health effects. However, there is only limited evidence on their differential toxicological impact. Objectives: We aimed discriminate effects of generated by atmospheric aging combustion soot particles (SPs) (β-pinene)...
The health effects of exposure to secondary organic aerosols (SOAs) are still limited. Here, we investigated and compared the toxicities soot particles (SP) coated with β-pinene SOA (SOAβPin-SP) SP naphthalene (SOANap-SP) in a human bronchial epithelial cell line (BEAS-2B) residing at air–liquid interface. SOAβPin-SP mostly contained oxygenated aliphatic compounds from photooxidation, whereas SOANap-SP significant fraction aromatic products under similar conditions. Following exposure,...
Soot particles (SP) are ubiquitous components of atmospheric particulate matter and have been shown to cause various adverse health effects. In the atmosphere, freshly emitted SP can be coated by condensed low-volatility secondary organic inorganic species. addition, gas-phase oxidants may react with surface SP. Due chemical physical resemblance carbon backbone polyaromatic hydrocarbon species their potent oxidation products, we investigated biological responses BEAS-2B lung epithelial cells...
Ultrafine particles (UFP) are the smallest atmospheric particulate matter linked to air pollution-related diseases. The extent which UFP's physical and chemical properties contribute its toxicity remains unclear. It is hypothesized that UFP act as carriers for chemicals drive biological responses. This study explores robust methods generating reference understand these mechanisms perform toxicological tests. Two types of combustion-related with similar elemental carbon cores but different...
Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing interest in nanomedicine, but most of those that entered the clinical trials been withdrawn due to toxicity concerns. Therefore, there is an urgent need design low-risk and biocompatible SPION formulations. In this work, we present original safe-by-design nanoplatform made silica loaded with SPIONs decorated polydopamine (SPIONs@SiO2-PDA) study its biocompatibility performance by ad hoc thorough vitro vivo...
Abstract Ship emissions cause serious environmental impacts and adverse effects toward human health. Therefore, the International Maritime Organization (IMO) restricted fuel sulfur content (FSC) of marine fuels: FSC must be <0.5% m/m or <0.1% in emission control areas, covering a range fuels from distillate diesel-like to low-sulfur heavy oils (HFOs). As result, ship emissions, e.g., oxides particulate matter (PM) have been reduced. However, how correlates with toxicological potential...
Abstract The prevalence of allergic diseases is constantly increasing since few decades. Anthropogenic ultrafine particles (UFPs) and allergenic aerosols highly involved in this increase; however, the underlying cellular mechanisms are not yet understood. Studies observing these effects focused mainly on singular vivo or vitro exposures single particle sources, while there only limited evidence their subsequent combined effects. Our study aimed at evaluating effect to allergy‐related...
Abstract Ultrafine particles (UFP), diameter of &lt;0.1 µm, contribute to urban particulate air pollution. There is still not much evidence on their effects humans. Our study aims address possible lung metabolome. Alveolar epithelial cells (A549) together with macrophages (THP-1) were seeded the apical side insert membrane, and fibroblasts (MRC-5) downside, respectively. Triple cell cultures exposed at liquid interface different aerosols generated by a combustion aerosol standard (CAST)...
Particularly since the wide-ranging health effects of asbestos exposure became known, great emphasis has been placed on detailed toxicity testing known but also newly developed fiber materials. Exposure to respirable pollutants like fibers can lead tissue injury causing lung diseases such as pulmonary fibrosis or cancer. In order detect toxic potential aerosols at an early stage, development suitable test systems is essential. this study, we illustrate advanced in vitro cell model closely...
Abstract Especially through the release from anthropogenic sources, there is growing concern about human exposure to ultrafine particulate matter (UFP). Inhalation of UFP associated with respiratory diseases such as asthma, pulmonary fibrosis and lung cancer, but their mechanisms action are still vastly unknown. In this study we aimed address question whether physical characteristics contribute most toxicity or particles primarily act carriers toxic chemicals. For scope, two distinct...
Einleitung Die gesundheitsschädliche Wirkung von ultrafeinen Partikeln (UFP; < 100 nm), die vor allem im Verkehr produziert werden, ist weitestgehend unbekannt. Das Epithel der Atemwege stellt wichtigste Kontaktregion für UFP dar. Zur toxikologischen Beurteilung in vitro werden diese Regel Flüssigkeit gelöst, was gerade bei einen relevanten Einfluss auf den schädigenden Effekt haben könnte. Ziel Arbeit war es, ein Expositionssystem luftgetragene humanes Modell oberen anzupassen.
The increasing demand for lightweight materials with exceptional stability and durability has resulted in a significant rise fiber-reinforced plastic (FRP) production. These find applications various fields, ranging from short-term usage to long-term implementation the energy construction sectors. Generally, glass- carbon fibers are embedded thermoset matrix based on polyester or epoxy resins. However, properties diverse compositional range of FRPs pose challenges conventional recycling...
Introduction Ultrafine particles (UFP; <100nm) are generated, e.g., by traffic, and their effects on human health poorly understood. A first important interaction between our bodies UFPs occur in the airways. In toxicological vitro studies, commonly dissolved liquid, which may have a relevant impact UFP’s effects. The aim here was to adapt an air-borne particle exposure system model of upper
The increasing demand for lightweight materials with exceptional stability and durability has resulted in a significant rise fiber-reinforced plastic (FRP) production. These find applications various fields. However, the properties diverse compositional range of FRPs pose challenges to conventional recycling strategies. Pyrolysis emerged as highly promising approach separating fibers from polymer matrix. In this study, we employed thermal analysis coupled high-resolution mass spectrometry...