A5053656235- Air Quality and Health Impacts
- Atmospheric chemistry and aerosols
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Energy and Environment Impacts
- Extracellular vesicles in disease
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Toxic Organic Pollutants Impact
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Maritime Transport Emissions and Efficiency
- Occupational and environmental lung diseases
- Nanoparticles: synthesis and applications
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Machine Learning and ELM
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- MicroRNA in disease regulation
Helmholtz Zentrum München
2022-2024
University of Rostock
2022-2024
Lund University
2019
Background: Secondary organic aerosols (SOAs) formed from anthropogenic or biogenic gaseous precursors in the atmosphere substantially contribute to ambient fine particulate matter [PM ≤2.5μm aerodynamic diameter (PM2.5)] burden, which has been associated with adverse human health effects. However, there is only limited evidence on their differential toxicological impact. Objectives: We aimed discriminate effects of generated by atmospheric aging combustion soot particles (SPs) (β-pinene)...
Abstract Purpose: Liquid biopsy has great potential to improve the management of brain tumor patients at high risk surgery-associated complications. Here, aim was explore plasma extracellular vesicle (plEV) immunoprofiling as a tool for noninvasive diagnosis glioma. Experimental Design: PlEV isolation and analysis were optimized using advanced mass spectrometry, nanoparticle tracking analysis, electron microscopy. We then established new procedure that combines size exclusion chromatography...
The health effects of exposure to secondary organic aerosols (SOAs) are still limited. Here, we investigated and compared the toxicities soot particles (SP) coated with β-pinene SOA (SOAβPin-SP) SP naphthalene (SOANap-SP) in a human bronchial epithelial cell line (BEAS-2B) residing at air–liquid interface. SOAβPin-SP mostly contained oxygenated aliphatic compounds from photooxidation, whereas SOANap-SP significant fraction aromatic products under similar conditions. Following exposure,...
Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like malignant GBM is characterized by hypoxic stress that triggers paracrine, adaptive responses, such as angiogenesis and macrophage recruitment, rescuing cancer cells from metabolic catastrophe conventional oncological treatments. The unmet need of strategies to efficiently target tumor "stressness" represents a strong clinical motivation better understand underlying mechanisms adaptation....
Soot particles (SP) are ubiquitous components of atmospheric particulate matter and have been shown to cause various adverse health effects. In the atmosphere, freshly emitted SP can be coated by condensed low-volatility secondary organic inorganic species. addition, gas-phase oxidants may react with surface SP. Due chemical physical resemblance carbon backbone polyaromatic hydrocarbon species their potent oxidation products, we investigated biological responses BEAS-2B lung epithelial cells...
Ultrafine particles (UFP) are the smallest atmospheric particulate matter linked to air pollution-related diseases. The extent which UFP's physical and chemical properties contribute its toxicity remains unclear. It is hypothesized that UFP act as carriers for chemicals drive biological responses. This study explores robust methods generating reference understand these mechanisms perform toxicological tests. Two types of combustion-related with similar elemental carbon cores but different...
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), type lipid droplet–loaded macrophage, in human glioblastoma. Through extensive analyses patient tumors, together with vitro and vivo investigations, found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, impaired phagocytosis, their presence correlates worse outcomes for...
Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing interest in nanomedicine, but most of those that entered the clinical trials been withdrawn due to toxicity concerns. Therefore, there is an urgent need design low-risk and biocompatible SPION formulations. In this work, we present original safe-by-design nanoplatform made silica loaded with SPIONs decorated polydopamine (SPIONs@SiO2-PDA) study its biocompatibility performance by ad hoc thorough vitro vivo...
Abstract Ship emissions cause serious environmental impacts and adverse effects toward human health. Therefore, the International Maritime Organization (IMO) restricted fuel sulfur content (FSC) of marine fuels: FSC must be <0.5% m/m or <0.1% in emission control areas, covering a range fuels from distillate diesel-like to low-sulfur heavy oils (HFOs). As result, ship emissions, e.g., oxides particulate matter (PM) have been reduced. However, how correlates with toxicological potential...
Abstract The prevalence of allergic diseases is constantly increasing since few decades. Anthropogenic ultrafine particles (UFPs) and allergenic aerosols highly involved in this increase; however, the underlying cellular mechanisms are not yet understood. Studies observing these effects focused mainly on singular vivo or vitro exposures single particle sources, while there only limited evidence their subsequent combined effects. Our study aimed at evaluating effect to allergy‐related...
Particularly since the wide-ranging health effects of asbestos exposure became known, great emphasis has been placed on detailed toxicity testing known but also newly developed fiber materials. Exposure to respirable pollutants like fibers can lead tissue injury causing lung diseases such as pulmonary fibrosis or cancer. In order detect toxic potential aerosols at an early stage, development suitable test systems is essential. this study, we illustrate advanced in vitro cell model closely...
Abstract Secondary organic aerosols (SOAs) formed from anthropogenic or biogenic volatile precursors in the atmosphere substantially contribute to ambient fine particulate matter (PM2.5) burden, which has been associated with adverse human health effects. However, there is only limited evidence of their differential toxicological impact. To study those effects, we generated different by atmospheric aging (β-pinene) (naphthalene) SOA that condensed on soot particles (SPs). In-depth,...
Abstract Traffic emissions contribute to ambient air pollution, posing a threat human health. The installation of stricter exhaust emission standards and particle filters led significant decrease particulate matter by cars. However, little is known about how atmospheric transformation changes the toxicity from modern We evaluated physico-chemical properties toxicological effects fresh photochemically aged aerosols gasoline EURO 6 car equipped with filter. A549 alveolar BEAS-2B bronchial...
Abstract Especially through the release from anthropogenic sources, there is growing concern about human exposure to ultrafine particulate matter (UFP). Inhalation of UFP associated with respiratory diseases such as asthma, pulmonary fibrosis and lung cancer, but their mechanisms action are still vastly unknown. In this study we aimed address question whether physical characteristics contribute most toxicity or particles primarily act carriers toxic chemicals. For scope, two distinct...