A5006600143- Autism Spectrum Disorder Research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Gut microbiota and health
- Neural dynamics and brain function
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Oral Health Pathology and Treatment
- FOXO transcription factor regulation
- Smoking Behavior and Cessation
- Parkinson's Disease Mechanisms and Treatments
- Child Nutrition and Feeding Issues
- MRI in cancer diagnosis
- Head and Neck Cancer Studies
- Appendicitis Diagnosis and Management
- Pelvic floor disorders treatments
- Cancer Mechanisms and Therapy
- Infant Health and Development
- Tryptophan and brain disorders
- Intestinal Malrotation and Obstruction Disorders
Southern Medical University
2019-2025
Zhujiang Hospital
2022-2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Tianjin Medical University
2022-2023
Abstract Background Autism spectrum disorder (ASD) is a developmental disorder, and the effective pharmacological treatments for core autistic symptoms are currently limited. Increasing evidence, particularly that from clinical studies on ASD patients, suggests functional link between gut microbiota development of ASD. However, mechanisms linking with brain dysfunctions (gut-brain axis) in have not yet been full elucidated. Due to its genetic mutations downregulated expression patients ASD,...
As one of the most aggressive malignant tumor in central nervous system, main cause poor outcome glioblastoma (GBM) is recurrence, a non-invasive method which can predict area recurrence pre-operation necessary.To investigate whether there radiological heterogeneity within peritumoral edema and identify reproducible radiomic features predictive sites glioblastoma(GBM), may be value to optimize patients' management.The clinical information MR images (contrast-enhanced T1 weighted FLAIR...
ABSTRACT Aims Dopamine replacement therapy is the backbone of Parkinson's disease (PD) treatment. However, long‐term levodopa ( L ‐DOPA) administration can lead to severely disabling motor complication L‐DOPA‐induced dyskinesia (LID), for which standard, effective currently lacking. This study was conducted characterize distinct neural electrophysiological patterns involved in progression PD and examine efficacy tetrabenazine, a vesicular monoamine transporter‐2 inhibitor, alleviating its...
Parkinson's disease (PD) is a pervasive neurodegenerative disease, and levodopa (L-dopa) its preferred treatment. The pathophysiological mechanism of levodopa-induced dyskinesia (LID), the most common complication long-term L-dopa administration, remains obscure. Accumulated evidence suggests that dopaminergic as well non-dopaminergic systems contribute to LID development. As 5-hydroxytryptamine 1A/1B receptor agonist, eltoprazine ameliorates dyskinesia, although little known about...
The study analyzed gut microflora's composition and investigated the associations between dysbiosis inflammatory indicators in pediatric patients with acute appendicitis. High-throughput sequencing bioinformatics analysis were used to investigate diversity of microflora 20 appendicitis 11 healthy children. Endpoints measured operational taxonomic units (OTU) microflora. OTU its abundance analysis, sample principal component samples, differential biomarkers performed. Overall fecal microbial...
JOURNAL/nrgr/04.03/01300535-202504000-00031/figure1/v/2024-07-06T104127Z/r/image-tiff Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia. Gamma oscillations are a widely recognized hallmark abnormal neural electrical activity in Currently, studies have reported increased oscillation power cases However, little is known about how other electrophysiological parameters gamma altered Furthermore, role dopamine D3 receptor, which implicated dyskinesia,...
Abstract Background: Distinguishing Alzheimer's disease (AD) from frontotemporal dementia (FTD) poses a clinical challenge, and to address this, inexpensive accessible techniques, such as electroencephalography (EEG), are increasingly being employed. However, current studies on electrophysiology have not adequately separated aperiodic activity spectral analysis instead evaluated the combination of periodic oscillatory components components. As understanding has evolved, its potential...
Medulloblastoma (MB) is the most frequent malignant brain tumor in pediatrics. Since current standard of care for MB consisting surgery, cranio‑spinal irradiation and chemotherapy often leads to a high morbidity rate, number patients suffer from long‑term sequelae following treatment. Targeted therapies hold promise being more effective less toxic. Therefore, present study aimed identify hub genes with an upregulated expression search potential therapeutic targets these genes. For this...
Abstract Background Autism spectrum disorder (ASD) is a developmental disorder, and the effective pharmacological treatments for core autistic symptoms are currently limited. Increasing evidence, particularly that from clinical studies on ASD patients, suggests functional link between gut microbiota development of ASD. However, mechanisms linking with brain dysfunctions (gut-brain axis) in have not yet been full elucidated. Due to its genetic mutations downregulated expression patients ASD,...
Abstract Autism spectrum disorder (ASD) is a developmental with no effective pharmacological treatments so far. Gut microbiota has been suggested to contribute autistic symptoms. However, the key genes and mechanisms linking gut brain dysfunctions in ASD are still unclear. Here, we found deletion of EphB6, an ASD-associated candidate gene, induced dysregulated autism-like behavior mice. More importantly, transplanting fecal from EphB6-deficient mice resulted disturbed antibiotics-treated...
Abstract Background Autism spectrum disorder (ASD) is a developmental with limited effective pharmacological treatments for the core autistic symptoms so far. Increasing evidences, especially clinical studies in ASD patients, suggest functional link between gut microbiota and development of ASD. However, mechanisms linking brain dysfunctions (gut-brain axis) are still not well-established. With genetic mutations down-regulated expression patients ASD, EPHB6, which also important homeostasis...
Abstract Background Autism spectrum disorder (ASD) is a developmental with limited effective pharmacological treatments for the core autistic symptoms so far. Increasing evidences, especially clinical studies in ASD patients, suggest functional link between gut microbiota and development of ASD. However, mechanisms linking brain dysfunctions (gut-brain axis) are still not well-established. With genetic mutations down-regulated expression patients ASD, EPHB6 , which also important homeostasis...