A5040579911- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Glioma Diagnosis and Treatment
- Nerve injury and regeneration
- Neural dynamics and brain function
- DNA Repair Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Hydraulic Fracturing and Reservoir Analysis
- Neurogenesis and neuroplasticity mechanisms
- Neuroblastoma Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Genetic Neurodegenerative Diseases
- Groundwater flow and contamination studies
- DNA and Nucleic Acid Chemistry
- PARP inhibition in cancer therapy
- Plant Genetic and Mutation Studies
Zhujiang Hospital
2016-2025
Southern Medical University
2016-2025
Guiyang Medical University
2022-2024
Bridge University
2023
Kunming University of Science and Technology
2023
Affiliated Hospital of Guizhou Medical University
2019
Guiyang University
2019
Guizhou University
2019
Cleveland Clinic
2011
Sinopec (China)
2007
ABSTRACT Aims Dopamine replacement therapy is the backbone of Parkinson's disease (PD) treatment. However, long‐term levodopa ( L ‐DOPA) administration can lead to severely disabling motor complication L‐DOPA‐induced dyskinesia (LID), for which standard, effective currently lacking. This study was conducted characterize distinct neural electrophysiological patterns involved in progression PD and examine efficacy tetrabenazine, a vesicular monoamine transporter‐2 inhibitor, alleviating its...
Abstract We present an analytical approach for pressure transient test analysis in naturally fractured vuggy reservoirs. This relies on a triple-continuum concept, using observed geological data from carbonate oil formations western China, to describe flow behavior fracture-vug-matrix In the conceptual mathematical model, rock is considered as medium, consisting of fractures, matrix, and vugs (or cavities). Similar classical double-porosity fracture continuum assumed be responsible...
Parkinson's disease (PD) is a pervasive neurodegenerative disease, and levodopa (L-dopa) its preferred treatment. The pathophysiological mechanism of levodopa-induced dyskinesia (LID), the most common complication long-term L-dopa administration, remains obscure. Accumulated evidence suggests that dopaminergic as well non-dopaminergic systems contribute to LID development. As 5-hydroxytryptamine 1A/1B receptor agonist, eltoprazine ameliorates dyskinesia, although little known about...
Objective Levodopa (L-dopa) therapy is the principal pharmacological treatment for Parkinson’s disease (PD). Nevertheless, prolonged use of this drug may result in different involuntary movement symptoms caused by medication, referred to as levodopa-induced dyskinesia (LID). LID associated with changes synaptic plasticity D1 medium spiny neurons (MSNs) located dorsal striatum (dStr). Within striatum, amount Dopamine D3 receptor (D3R) notably increased LID, demonstrating colocalization D1R...
We present an analytical approach for pressure transient test analysis in naturally fractured vuggy reservoirs. This relies on a triple-continuum concept, using observed geological data from carbonate oil formations western China, to describe flow behavior fracture-vug-matrix In the conceptual mathematical model, rock is considered as medium, consisting of fractures, matrix, and vugs (or cavities). Similar classical double-porosity fracture continuum assumed be responsible occurrence global...
Teriparatide is a commonly used drug indicated for the treatment of osteoporosis in postmenopausal women. can also upregulate Ang-1 expression through AC/PKA signaling pathway to promote angiogenesis. At present, promoting angiogenesis promising but unrealized strategy ischemic cerebral infarction. However, there are few studies on application teriparatide We treat infarction rats and obtained three major findings. First, angiogenesis, reduce infarct size, increase perfusion by upregulating...
Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, lack understanding its electrophysiological characteristics limits improvement effect.To investigate CM-pf underlying (DoC) and recovery.We collected signals from 23 DoC patients who underwent central thalamus DBS (CT-DBS) surgery. Five typical features were extracted, including neuronal firing properties, multiunit...
BACKGROUND UCA1 is a long non-coding RNA that has been found to be aberrantly upregulated in various cancers. The aim of this study was determine the expression level and function medulloblastoma, most common malignant brain tumor during childhood. MATERIAL AND METHODS Real-time PCR used detect medulloblastoma specimens cell lines. Lentiviral-mediated short hairpin (shRNA) targeting or negative control shRNA also achieved with line, Daoy. Cell proliferation cycle progression were...
Myelin and lymphocyte protein 2 (MAL2) is mainly involved in endocytosis under physiological conditions mediates the transport of materials across membranes cell organelle. It has been reported that MAL2 significantly upregulated diverse cancers. This study aimed to investigate role breast cancer (BC).Bioinformatics analysis Immunohistochemical assay were applied detect correlation between expression tissues prognosis patients. Functional experiments carried out vitro vivo. The molecular...