A5031050749- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Planarian Biology and Electrostimulation
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Microtubule and mitosis dynamics
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- bioluminescence and chemiluminescence research
- Renal and related cancers
- Hippo pathway signaling and YAP/TAZ
- Axon Guidance and Neuronal Signaling
- Gene Regulatory Network Analysis
- Circadian rhythm and melatonin
- Kruppel-like factors research
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Marine Invertebrate Physiology and Ecology
- Neonatal Respiratory Health Research
Osaka University
2020-2024
Kyoto University
2012-2023
Ube Frontier University
2020
Material Sciences (United States)
2018
Japan Science and Technology Agency
2008-2014
Notch signaling regulates tissue morphogenesis through cell–cell interactions. The effectors Hes1 and Hes7 are expressed in an oscillatory manner regulate developmental processes such as neurogenesis somitogenesis, respectively. Expression of the mRNA for mouse ligand Delta-like1 (Dll1) is also oscillatory. However, dynamics Dll1 protein expression controversial, their functional significance unknown. Here, we developed a live-imaging system found that oscillated neural progenitors...
In neural stem/progenitor cells, expression of the Notch effector Hes1, a transcriptional repressor, oscillates with period 2-3 h by negative feedback, and Hes1 oscillations induce oscillatory proneural gene Neurogenin2 (Ngn2) ligand Delta-like1 (Dll1). Dll1 oscillation leads to mutual activation signaling between neighboring thereby maintaining group cells in undifferentiated state. Not all express an manner: boundary regions such as isthmus sustained manner, these are rather dormant regard...
Somitogenesis is controlled by cyclic genes such as Notch effectors and the wave front established morphogens Fgf8, but precise mechanism of how these factors are coordinated remains to be determined. Here, we show that Fgf pathways oscillate in different dynamics oscillations signaling generate alternating phase shift, thereby periodically segregating a group synchronized cells, whereas released cells for somitogenesis at same time. These results suggest oscillators define prospective...
Abstract Cell-cell interactions mediated by Notch are critical for the maintenance of skeletal muscle stem cells. However, dynamics, cellular source and identity functional ligands during expansion cell pool in growth regeneration remain poorly characterized. Here we demonstrate that oscillating Delta-like 1 (Dll1) produced myogenic cells is an indispensable ligand self-renewal mice. Dll1 expression controlled target Hes1 regulatory factor MyoD. Consistent with our mathematical model,...
The expression of the transcriptional repressor Hes1 oscillates in many cell types, including neural progenitor cells (NPCs), but significance oscillations development is not fully understood. To examine effect altered oscillatory dynamics Hes1, we generated two types
Abstract During mammalian brain development, neural stem cells transform from neuroepithelial to radial glial and finally remain as astrocyte-like in the postnatal adult brain. Neuroepithelial divide symmetrically expand cell pool; after onset of neurogenesis, sequentially produce deep layer neurons then superficial by asymmetric, self-renewing divisions during cortical development. Thereafter, gliogenesis supersedes while a subset retain their stemness lurk Thus, undergo alterations...
Neural stem cells (NSCs) differentiate into neuron-fated intermediate progenitor (IPCs) via cell division. Although differentiation from NSCs to IPCs is a discrete process, recent transcriptome analyses identified continuous transcriptional trajectory during this raising the question of how reconcile these contradictory observations. In mouse NSCs, Hes1 expression oscillates, regulating oscillatory proneural gene Neurog2, while disappears in IPCs. Thus, transition oscillation suppression...