A5067902356- Adenosine and Purinergic Signaling
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Organ and Tissue Transplantation Research
- Mast cells and histamine
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Phagocytosis and Immune Regulation
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic function and diabetes
- Venomous Animal Envenomation and Studies
- Cancer Cells and Metastasis
- Calcium signaling and nucleotide metabolism
Universidade de São Paulo
2018-2025
Drug resistance is a major challenge for all oncological treatments that involve the use of cytotoxic agents. Recent therapeutic alternatives cannot circumvent ability cancer cells to adapt or alter natural selection resistant cells, so problem persists. In neuroblastoma, recurrence can occur in up 50% high-risk patients. Therefore, identification novel targets capable modulating survival death following classical antitumor interventions crucial address this problem. study, we investigated...
Purinergic signaling has been implicated in many biological functions, including development. In this study, we investigate the functions of extracellular adenosine and receptors using a mouse embryonic stem cell (ESC) line morula stages isolated from embryos. Feeder-free ESC was investigated absence presence leukemia inhibitory factor (LIF), configuring undifferentiated cells undergoing spontaneous differentiation. High alkaline phosphatase (ALPL) low CD73 levels resulting (eADO) were...