A5087236276- Nutrition and Health in Aging
- Stroke Rehabilitation and Recovery
- Cancer survivorship and care
- Adipokines, Inflammation, and Metabolic Diseases
- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- Childhood Cancer Survivors' Quality of Life
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Cancer-related cognitive impairment studies
- Health, Environment, Cognitive Aging
- Exercise and Physiological Responses
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Cerebral Palsy and Movement Disorders
- Muscle Physiology and Disorders
- Balance, Gait, and Falls Prevention
- Frailty in Older Adults
- Eating Disorders and Behaviors
- Animal Diversity and Health Studies
- Stress Responses and Cortisol
- Ecology and biodiversity studies
- Tryptophan and brain disorders
- Children's Physical and Motor Development
- Physical Activity and Health
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2015-2025
Slovak Academy of Sciences
2017-2025
Biomedical Research Center of the Slovak Academy of Sciences
2024
Comenius University Bratislava
2015-2021
Abstract Background Platinum‐based chemotherapy provides curative treatment to more than 95% of patients with testicular germ cell tumor but it has negative cardiometabolic and neurological effects. Regular exercise can alleviate late chemotherapy‐related toxicities. We examined the impact a 6‐month supervised aerobic‐strength training on cognitive health residual level platinum in cancer survivors. Methods Twenty‐eight middle‐aged (42.1 ± 7.6 years) survivors subjected platinum‐based (1–8...
Regular exercise ameliorates motor symptoms in Parkinson's disease (PD). Here, we aimed to provide evidence that brings additional benefits the whole-body metabolism and skeletal muscle molecular functional characteristics, which might help explain exercise-induced improvements clinical state. 3-months supervised endurance/strength training was performed early/mid-stage PD patients age/gender-matched individuals (n = 11/11). The effects of on resting energy expenditure (REE), glucose...
Abstract Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms mediators exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin other bioactive molecules cerebrospinal fluid (CSF) serum from young lean individuals. Samples CSF were obtained before 1-h after 90-min run (75–80% HRmax; maximal heart rate), additional was taken at finish-line. Body composition, physical...
The study compared the effect of 12-week multimodal training programme performed twice a week at regular exercise facility (REF) with three times per as part research (EX). Additionally, analysed how experimental affect physical performance cognitive healthy and mild impaired elderly (MCI). REF group included 19 (65.00±3.62 years). combined cognitively (EXH: n=16; 66.3±6.42 years) age-matched individuals MCI (EXMCI: n=14; 66.00±4.79 10m maximal walking speed (10mMWS), Five Times Sit-to-Stand...
<b><i>Background/Aims:</i></b> Walking speed (WS) is an objective measure of physical capacity and a modifiable risk factor morbidity mortality in the elderly. In this study, we (i) determined effects 3-month supervised aerobic-strength training on WS, muscle strength, habitual activity; (ii) evaluated long-term (21 months) to sustain higher WS; (iii) identified determinants WS <b><i>Methods:</i></b> Volunteers (F 48/M 14, 68.4 ± 7.1 years)...
Regular physical exercise represents physiological, available and effective means of preserving or improving cognitive functions, especially at early stages impairment. To assess the impact training on & muscle perfomance fitness, we have performed a 3-months intervention study in 13 seniors with (n=9) without (n=4) mild impairment (MCI). Phenotyping before after 3-month included tests (Montreal Cognitive Assessment, MoCA; Addenbrooke's Examination, ACE-R), assessment resting metabolic rate...
Background Thyroid hormones profoundly affect energy metabolism but their interrelation with food preference, which might contribute to childhood obesity development, are much less understood. In this study, we investigated if thyroid hormone levels associated specific modulation of preference and potentially linked the level in children adolescents. Methods Interrelations between peripheral activity were examined a population 99 non-obese 101 obese adolescents (12.8 ± 3.6 years age, 111/89...
Abstract Background Physical exercise improves clinical state of patients with Parkinson’s disease (PD), and evidence from experimental models suggests it has a potential to slow down the progression. Improved glucose metabolism as well exerkines, bioactive molecules released into circulation each bout, contribute synchronized exercise‐induced adaptive response at systemic level. Our aim was assess effects on molecular changes in cerebrospinal fluid (CSF) blood PD. Methods Patients PD...
Abstract Background The risk of cognitive decline in cancer survivors may be increased by platinum‐based chemotherapy. Evidence indicates that physical exercise has a potential to reduce chemotherapy‐related toxicity. aim this study was assess effects 6‐month aerobic‐strength training on functions, metabolic flexibility, anthropometric parameters and fitness testicular germ cell tumor (TGCT) survivors, treated with Methods TGCT underwent intervention (supervised training/ controls n = 20/8,...
Evidence indicates that sedentary lifestyle may lead to impairments in cognition and glucose metabolism. Recent studies showed exercise can prevent age-related cognitive metabolic decline. We aimed (i) evaluate the impact of physical activity on brain morphology seniors with/without mild impairment (MCI) and/or impaired metabolism (IGM); (ii) determine effects 3-month aerobic-strength training cognitive, motor functions. Study population (n=109; M/F=38/71; BMI=26.2±4.3kg/m2; 68.1±7.1yrs)...
Regular physical exercise has been shown to improve cognitive functions in individuals with mild impairment (MCI). To assess effects of on specific markers cerebrospinal fluid (CSF), we have performed lumbar puncture 9 seniors (age 66,3±2,5y) (n=4/0 F/M) or without (n=2/3 MCI, before and after 3-month training. Intervention: aerobic-strength training (1h 3x/week, 60-70% VO2max 1RM, resp., increasing work load respect fitness/strength). Phenotyping before/after included tests (Adenbrooke’s...
Abstract Background Exercise improves physical fitness, cognitive functions & metabolism in the elderly. Evidence from animal models suggests role for mediators muscle or adipose tissue exercise‐induced brain plasticity (1). Knowledge on regulation of these potentially neuroprotective molecules by exercise humans is limited (2,3). We investigated effects 3‐month supervised aerobic‐strength training serum cerebrospinal fluid/CSF adiponectin elderly, association with volumetry. Method The...
Parkinson's disease (PD) increases cardiometabolic risk that reciprocally accelerates progression of PD. Regular physical exercise has been shown to improve motor and cognitive functions in individuals with early stage Sedentary volunteers (11 healthy 11 PD patients; M/F 10/12; 64.6±1.5yrs; BMI 27.7±0.95kg.m-2) underwent supervised 3-month endurance-strength training (3x1h/week). Subgroup 6 continued the program for one-year. Clinical state was evaluated by neurologist, (MDS-UPDRS). Physical...
Abstract Background Physical inactivity accelerates ageing‐associated cognitive decline while regular physical exercise improves neurocognitive health, in parallel with improvements of fitness and whole‐body metabolism. However, the knowledge on putative bioactive molecules, mediators benefits human brain is still very limited. Our aim was to evaluate effects aerobic‐strength training intervention spectrum chemokines/cytokines cerebrospinal fluid (CSF) elderly individuals. Method The CSF...