A5019478885- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Spatial Cognition and Navigation
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Brain Tumor Detection and Classification
- Epilepsy research and treatment
- Spatial Neglect and Hemispheric Dysfunction
- Gait Recognition and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Geriatric Care and Nursing Homes
- Health Systems, Economic Evaluations, Quality of Life
- Neurological and metabolic disorders
- Pharmaceutical Practices and Patient Outcomes
- EEG and Brain-Computer Interfaces
- Neurobiology of Language and Bilingualism
- Cholinesterase and Neurodegenerative Diseases
- Diabetic Foot Ulcer Assessment and Management
- Older Adults Driving Studies
- Health and Well-being Studies
- Neural and Behavioral Psychology Studies
- Sleep and related disorders
National Cheng Kung University Hospital
2015-2024
National Cheng Kung University
2015-2024
Cambridge University Press
2017
Behavioral Pharma (United States)
2005-2017
International Society of Nephrology
2017
Taipei Institute of Pathology
2012
Neurology, Inc
2007
Chi Mei Medical Center
2006
Health Sciences Centre
1980
McMaster University Medical Centre
1980
Despite patients with Alzheimer's disease (AD) were reported of revealing gait disorders and balance problems, there is still lack objective quantitative measurement patterns capability AD patients. Based on an inertial-sensor-based wearable device, this paper develops analyzing algorithms to obtain measurements explores the essential indicators from for diagnosis. The algorithm composed stride detection followed by cycle decomposition so that parameters are developed decomposed details. On...
Although exercise is an effective way to decrease the risk of developing Alzheimer's disease, biological basis for such benefits from different modes remains elusive. The present study thus aimed (i) investigate effects acute aerobic or resistance on neurocognitive performances and molecular markers when performing a cognitive task involving executive functioning in older adults with amnestic mild impairment (aMCI), (ii) explore relationships exercise-induced changes circulating levels...
Background: Decreased levels of the neuroprotective growth factors, low-grade inflammation, and reduced neurocognitive functions during aging are associated with neurodegenerative diseases, such as Alzheimer’s disease. Physical exercise modifies these disadvantageous phenomena while a sedentary lifestyle promotes them. Purpose: The purposes present study included investigating whether both aerobic resistance produce divergent effects on inflammatory cytokines, performance, further exploring...
Based on the hypothesis that declarative memory and navigation ability depend hippocampal integrity, fact declines early in Alzheimer's disease (AD), authors suggest topographical disorientation (TD) will be an manifestation of AD.Patients diagnosed with AD based DSM-IV criteria, residing at home, were studied a clinic 1000-bed referral medical center. Patient characteristics, condition, performance neuropsychological tests, function compared between patients without current TD. Information...
It has been demonstrated that peripheral injection of anti-amyloid-β (Aβ) antibodies to patients with Alzheimer's disease (AD) and AD transgenic mice facilitate Aβ clearance. We hypothesized circulating Aβ-binding proteins also possess the ability enhance clearance levels could serve as early biomarkers. Circulating were isolated from plasma identified by LC-MS/MS. Their compared among non-demented individuals without family history (ND), (ND-FH), mild AD. The results showed most...
There is growing awareness of the coexistence Alzheimer's disease and cerebrovascular (AD+CVD), however, due to lack well-defined criteria treatment guidelines AD+CVD may be underdiagnosed in Asia.Sixteen dementia specialists from nine Asia Pacific countries completed a survey September 2014 met November review epidemiology, diagnosis Asia. A consensus was reached by discussion, with evidence provided published studies when available.AD accounts for up 60% 10-20% all cases The reasons...
Objective Given the shortage of cost-of-illness studies in dementia outside Western population, current study estimated annual cost Taiwan and assessed whether different categories care costs vary by severity using multiple disease-severity measures. Methods This included 231 patient–caregiver dyads a clinic at national university hospital southern Taiwan. Three disease measures including cognitive, functional, behavioral disturbances were obtained from patients based on medical history. A...
This paper presents an inertial-sensor-based wearable device and its associated stride detection algorithm to analyze gait information for patients with Alzheimer's disease (AD). The analysis is composed of a triaxial accelerometer, microcontroller, RF wireless transmission module. To validate the effectiveness proposed algorithm, nine AD three healthy controls were recruited participate experiment. They asked mount on their foot walk along straight line 40 meters at normal speed. consisting...
Both amyloid plaques and neurofibrillary tangles are pathological hallmarks in the brains of patients with Alzheimer's disease (AD). However, constituents these hallmarks, beta (Aβ) 40, Aβ42, total Tau (t-Tau), have been detected blood cognitively normal subjects by using an immunomagnetic reduction (IMR) assay. Whether levels age dependent is not known, their interrelation remains undefined. We determined biomarkers different groups. A 391 aged 23 to 91 were enrolled from hospitals Asia,...
<i>Background:</i> A polymorphism locating at position 73 of cystatin C <i>(CST3)</i> exon 1 was suggested to be associated with Alzheimer disease (AD), but contradictory results. The relationship between the <i>CST3</i> genotype and plasma level in AD remains unknown. <i>Objective:</i> We aim determine association levels nondemented control individuals. <i>Method:</i> polymorphisms were determined using PCR followed by restriction...
ABSTRACT Background: The aim of this study was to examine and test the sensitivity, specificity, threshold scores Montreal Cognitive Assessment (MoCA) Mini-Mental State Examination (MMSE) determine those that best correspond a clinical diagnosis dementia with Lewy bodies (DLB). Methods: Sixty-seven Alzheimer's disease (AD), 36 DLB, 62 healthy participants without (NC), aged 60 90, were enrolled. All three groups took MoCA MMSE tests at same time. Cochran–Mantel–Haenszel receiver operating...
Although elderly people with amnestic mild cognitive impairment (aMCI) have been found to show impaired behavioral performance in task switching, no research has yet explored the electrophysiological mechanisms and potential correlation between physical fitness neurocognitive (i.e., behavio ral electrophysiological) aMCI. The present study was thus aimed examine whether there are differences event-related potential) aMCI participants controls when performing a task-switching paradigm,...
Many early-stage Alzheimer's disease (AD) patients suffer from spatial navigational impairment even in familiar environments. Growing evidence shows that the retrosplenial cortex (RSC) is more damaged young-onset AD (YOAD, onset age before 65) than late-onset (LOAD) of AD. Impaired translation between egocentric and allocentric representations environment, as a cause for impairment, usually occurs people with lesions RSC.To test translational ability YOAD LOAD patients.Tests deemed sensitive...