A5084186301- Adipose Tissue and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Thyroid Cancer Diagnosis and Treatment
- Memory and Neural Mechanisms
- Dermatological and Skeletal Disorders
- Eosinophilic Disorders and Syndromes
- Neuroendocrine Tumor Research Advances
- Parathyroid Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Epilepsy research and treatment
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Radiation Therapy and Dosimetry
- Cardiac tumors and thrombi
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
Grigore T. Popa University of Medicine and Pharmacy
2021-2024
Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi
2021
The demand for tailored, disease-adapted, and easily accessible radiopharmaceuticals is one of the most persistent challenges in nuclear imaging precision medicine. In this study, two radiotracers were developed to bind SPECT PET radionuclides.
The high energy of α emitters, and the strong linear transfer that goes along with it, lead to very efficient cell killing through DNA damage. Moreover, degree oxygenation cycle state have no impact on these effects. Therefore, radioisotopes can offer a treatment choice individuals who are not responding β- or gamma-radiation therapy chemotherapy drugs. Only few α-particle emitters suitable for targeted alpha (TAT) clinical applications. majority available research involves 225Ac its...
A 62 years old woman was diagnosed with multinodular toxic goiter and primary hyperparathyroidism/left parathyroid adenoma by hormonal assessment, ultrasound nuclear thyroid/parathyroid scans. Cervical illustrated a aspect of the thyroid solid nodules cystic-component nodules; larger one represented complex necrosis areas in left lobe, ACR TI-RADS score 4 (moderately suspicious). Functional imaging performed for accurate differential diagnosis between vs. localization, cold hot nodules,...
Recent research has suggested that one novel mechanism of action for anti-obesity medications is to stimulate the activation brown adipose tissue (BAT). 18FDG PET/CT remains gold standard defining and quantifying BAT. SUVmax most often used quantification tool in clinical practice. However, this parameter does not reflect entire BAT volume. As a potential method precisely evaluating BAT, we have utilised metabolic tumour volume (MTV) total lesion glycolysis (TLG) answer question: Are MTV TLG...
Background: Technology allows us to predict a histopathological diagnosis, but the high costs prevent large-scale use of these possibilities. The current liberal indication for surgery in benign thyroid conditions led rising frequency incidental carcinoma, especially low-risk papillary micro-carcinomas. Methods: We selected cohort 148 patients with nodules by ultrasound characteristics and investigated them fine needle aspiration cytology (FNAC)and prospective BRAF collection 70 patients....
Brown adipose tissue (BAT) participates in the regulation of whole-body metabolism by producing a variety adipokines. This study investigates into BAT pattern and clinical aspects overweight obese (OOB) vs. non-obese (NO) hyperparathyroidism (HPT) patients with aim assessing impact obesity on HPT. Parathyroid scans performed 441 HPT between 2015 2020 were retrospectively analyzed order to select images active BAT. Based their BMI, divided OOB NO. The results showed that was present cervical...
Transthyretin cardiac amyloidosis (ATTR) is a rare protein deposition disease characterized by progressive thickening of both ventricles, the inter-atrial-ventricular septum and atrioventricular valves. The gold standard method for diagnosing this pathology endomyocardial biopsy. If cannot be used, alternative mixture clinical paraclinical tests. Over course five years, we examined 58 patients suspected based on electrocardiography ultrasonography criteria, who had been sent bone...
Background: Although strong clues in NETs diagnosis exist, a personalized is still puzzling. Quantitative functional imaging could identify the population for which treatment would bring greatest benefits.
Although neuroendocrine tumours (NETs) are intensively studied, their diagnosis and consequently personalised therapy management is still puzzling due to tumoral heterogeneity. In theragnosis algorithm, receptor somatostatin scintigraphy takes the central place, analogue (RSA) choice depending on laboratory experience accessibility. However, in all cases, results depend decisively correct radiotracer uptake quantification, where unfortunately there unrevealed clues lack of standardization....