A5090866104- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Advancements in Transdermal Drug Delivery
- Corneal Surgery and Treatments
- Curcumin's Biomedical Applications
- Graphene and Nanomaterials Applications
- Cancer Research and Treatment
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Pomegranate: compositions and health benefits
- Drug Transport and Resistance Mechanisms
- Retinal Development and Disorders
- Protein Interaction Studies and Fluorescence Analysis
- Natural Antidiabetic Agents Studies
- Retinopathy of Prematurity Studies
- Bone Tissue Engineering Materials
- Electrochemical sensors and biosensors
- Sesame and Sesamin Research
- Retinal Diseases and Treatments
- Essential Oils and Antimicrobial Activity
Waterford Institute of Technology
2017-2022
South East Technological University
2022
University of Delhi
2011-2020
Florida Agricultural and Mechanical University
2016-2018
The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation inflammation with steroids. Consequently, any modification that decreases this burden patients and doctors alike would be a welcome intervention. To end, research aims to develop topically applied nanoparticulate system encapsulating corticosteroid extended drug release. Poly (lactic-co-glycolic acid)...
Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation, discomfort and visual disturbance, standard treatment includes use lubricants topical steroids. Secondary inflammation plays prominent role in development propagation this debilitating condition. To address we have investigated pilot scale an innovative drug delivery system using dexamethasone-encapsulated...
Aim: Therapeutic efficacy of anticancer nanomedicine is compromised by tumor stromal barriers. The present study deals with the development docetaxel loaded PEGylated liposomes (DTXPL) and to investigate effect stroma disrupting agent, telmisartan, on DTXPL. Methods: DTXPL was prepared using proprietary modified hydration method. Effect oral telmisartan treatment uptake coumarin-6 evaluated in orthotopic xenograft lung bearing mice. Results: (105.7 ± 3.8 nm) showed very high physical...
The aim of present study was to develop conventional and PEGylated (long circulating), liposomes containing anastrozole (ANS) for effective treatment breast cancer. ANS is a third-generation non-steroidal aromatase inhibitor the triazole class used advanced late-stage cancer in post-menopausal women. Under such disease conditions median duration therapy should be prolonged until tumor regression ends (>31 months). Liposomes were prepared by thin film hydration method using various lipids as...
Clinicians face numerous challenges when delivering medications to the eyes topically because of physiological barriers, that can inhibit complete dose from getting intended location. Due their small size, ability deliver drugs different polarities simultaneously, and biocompatibility, liposomes hold great promise for ocular drug delivery. This study aimed develop characterise a dual loaded liposome formulation encapsulating Bevacizumab (BEV) Dexamethasone (DEX) possessed physicochemical...
Abstract In this article, a sustained release formulation of the antioxidant gallic acid (GA) is presented in form glutathione responsive disulfide cross-linked poly(ethylene glycol)-based nanogels synthesized via aqueous inverse miniemulsion using atom transfer radical polymerization. The particle size was found to be range from 227 ± 51.78 573.3 207.2 nm at three drug loading levels achieved i.e. 6.6, 14.26, and 18.29 wt.% with efficiency 60–70%. profile GA studied suggested controlled...
Ellagic acid (EA), a potential antioxidant phytochemical has low aqueous solubility and bioavailability. In this paper, encapsulation of ellagic been carried out into the biodegradable disulfide crosslinked poly (ethylene glycol) PEO-based nanogels synthesized via AGET (activator generated electron transfer) ATRP (atom transfer radical polymerization), their scavenging ability was evaluated. The EA at two drug loading percentages, that is, 10 20 wt.% nanogels. 1,1-Diphenyl-2-picryldrazyl...
Polymeric nanogels have been widely explored for their potential application as delivery carriers cancer therapeutics. The ability of to encapsulate therapeutics by simple diffusion mechanism and the ease fabrication impart target specificity in addition get internalized into cells make them good candidates drug delivery. present study aims investigate applicability poly(ethylene glycol)-co-methacrylamide-co-acrylic acid (PMA)-based a viable option doxorubicin (DOX). were synthesized free...
Polymeric self-assemblies formed by non-covalent interactions such as hydrophobic interactions, hydrogen bonding, π-π stacking, host-guest and electrostatic have been utilised widely exhibit controlled release of encapsulated drug. Beside carrier-carrier small molecule amphiphiles exhibiting carrier-drug recently an area interest for cancer drug delivery, most the anti-tumour drugs are aromatic conjugated structure. In present study PEG-coumarin (PC) conjugates forming self-assembled...
The fabrication of novel and intelligent delivery systems that can effectively deliver therapeutics to the targeted site release payload in enhanced/controlled manner is highly desired overcome multiple challenges chemotherapy. present article demonstrates potential application dual stimuli responsive nanogels as tumor microenvironment drug carrier. Disulfide cross-linked pH redox PEG-PDMAEMA were synthesized by atom transfer radical polymerization (ATRP). characterized nuclear magnetic...
This study details the formation and characterisation of a novel nicotinamide adenine dinucleotide (NAD+)-associated polymeric nanoparticle system. The development polyelectrolyte complex (PEC) composed two natural polyelectrolytes, hyaluronic acid poly(L-lysine), an evaluation its suitability for NAD+ ocular delivery, primarily based on physicochemical properties in vitro release profile under physiological flow rates, were key focus. Following optimisation formulation method conditions...
Age-related macular degeneration (AMD) is a multifactorial degenerative disease characterised by the gradual loss of central vision in individuals aged more than 50 years. There currently no cure for this disease, but treatment can delay its progression. Consequently, there an urgent need development both new and cost-effective therapeutics. In study, novel combination corticosteroid flavonoid was investigated on human retinal pigment epithelial cell lines to explore potential...