A5009038876- Lipid Membrane Structure and Behavior
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Electron and X-Ray Spectroscopy Techniques
- Diatoms and Algae Research
- RNA Interference and Gene Delivery
- Surface Modification and Superhydrophobicity
- Advanced Materials Characterization Techniques
- Modular Robots and Swarm Intelligence
- Photochromic and Fluorescence Chemistry
- Nanofabrication and Lithography Techniques
- Surface Roughness and Optical Measurements
- Sphingolipid Metabolism and Signaling
- Plasmonic and Surface Plasmon Research
- Surface and Thin Film Phenomena
- Supramolecular Self-Assembly in Materials
- Advancements in Photolithography Techniques
- Essential Oils and Antimicrobial Activity
- Optical Coatings and Gratings
- Silk-based biomaterials and applications
- Laser-Ablation Synthesis of Nanoparticles
- Photonic and Optical Devices
- Saffron Plant Research Studies
- Advanced Electron Microscopy Techniques and Applications
University of Turin
2017
Institute of Chemistry of the Slovak Academy of Sciences
2010
Slovak Academy of Sciences
2010
University of Milano-Bicocca
2010
Universidad Complutense de Madrid
2010
National Institute for Laser Plasma and Radiation Physics
2010
Instituto de Cerámica y Vidrio
2010
Instituto de Ciencia de Materiales de Madrid
2010
Retinitis pigmentosa (RP) is a genetic disease causing progressive apoptotic death of photoreceptors and, ultimately, incurable blindness. Using the retinal degeneration 10 (rd10) mouse model RP, we investigated role ceramide, proapoptotic sphingolipid, in degeneration. We also tested possibility that photoreceptor loss can be slowed or blocked by interfering with ceramide signaling pathway apoptosis vivo. Retinal levels increased rd10 mice during period maximum death. Single intraocular...
To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate.Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The of this novel has been investigated in vitro (cell adhesion to human vascular endothelial cells pro-inflammatory cytokine release by lipopolysaccharide-induced polymorphonuclear cells) vivo (disease index plasma concentrations dextran...
Abstract Background The widespread use of nano-biomaterials (NBMs) has increased the chance human exposure. Although ingestion is one major routes exposure to NBMs, it not thoroughly studied date. NBMs are expected be dramatically modified following transit into oral-gastric-intestinal (OGI) tract. How these transformations affect their interaction with intestinal cells still poorly understood. different chemical nature—lipid-surfactant nanoparticles (LSNPs), carbon (CNPs), surface Fe 3 O 4...
Solid lipid nanoparticles (SLNs) have gained interest as drug delivery carriers due to their efficient cellular internalization and increased therapeutic effect of the loaded drug, with minimal side effects. Although recently several studies shown possibility administer SLNs during pregnancy vehicle mRNA placenta, data about premating exposure on outcome are scant. Considering that assumption drug-delivering nanocarriers in reproductive age may potentially affect women's health, aim present...
Abstract The prevention of cone loss during retinal degeneration is a major goal most therapeutic strategies in degenerative diseases. An intriguing issue the current research this field to understand why genetic mutation that affects rods eventually leads death. main objective present study was investigate what extent rescuing from survival cones and prevents functional impairment visual performance. To purpose, we compared rod viabilities by both ex vivo determinations rd10 mutant mouse,...
BACKGROUND AND PURPOSE Cholesteryl butyrate solid lipid nanoparticles (cholbut SLN) provide a delivery system for the anti‐cancer drug butyrate. These SLN inhibit adhesion of polymorphonuclear cells to endothelium and may act as anti‐inflammatory agents. As cancer cell is crucial metastasis dissemination, here we have evaluated effect cholbut on migration cells. EXPERIMENTAL APPROACH Cholbut was incubated with number lines or human umbilical vein endothelial (HUVEC) quantified by...
Corticosteroids, although highly effective for the treatment of both anterior and posterior ocular segment inflammation, still nowadays struggle drug delivery due to their poor solubilization capabilities in water. This research work aims develop nanostructured lipid carriers (NLC) intended periocular administration dexamethasone acetate eye. Pre-formulation studies were initially performed find solid liquid mixtures solubilization. Pseudoternary diagrams at 65 °C constructed select best...
Clinicians face numerous challenges when delivering medications to the eyes topically because of physiological barriers, that can inhibit complete dose from getting intended location. Due their small size, ability deliver drugs different polarities simultaneously, and biocompatibility, liposomes hold great promise for ocular drug delivery. This study aimed develop characterise a dual loaded liposome formulation encapsulating Bevacizumab (BEV) Dexamethasone (DEX) possessed physicochemical...
Purpose. Histone modification has emerged as a promising approach to cancer therapy. The short-chain fatty acid, butyric histone deacetylase (HD) inhibitor, shown anticancer activity. Butyrate transcriptional activation is indeed able withdraw cells from the cell cycle, leading programmed death. Since butyrate’s clinical use hampered by unfavorable pharmacokinetic and pharmacodynamic properties, delivery systems, such solid lipid nanoparticles (SLN), have been developed overcome these...
The human pathogenic mold Aspergillus fumigatus is able to form a complex biofilm embedded in extracellular matrix. Biofilms confer antimicrobial resistance and it well known that aspergillosis often refractory the conventional antifungal therapy. treatment of biofilm-related infections poses significant clinical challenge on daily basis, promoting search for new therapeutic agents. Our aim was exploit modulation sphingolipid mediators as target overcome infections. Antifungal susceptibility...
Lipid-containing nanostructures, in the form of solid lipid nanoparticles or iron oxide (NPs) coated with a shell, were used as case studies for assessing and optimizing staining transmission electron microscopy structural compositional characterization. These systems are paramount importance drug delivery bio-compatible contrast agents. In particular, we have treated negative (phospshotungstic acid) positive (osmium tetroxide) agent. For iron-oxide NPs was more efficient respect to one....
Background and Purpose Solid lipid nanoparticles containing cholesteryl butyrate (cholbut SLN ) can be a delivery system for the anti‐cancer drug butyrate. These inhibit adhesion of polymorphonuclear tumour cells to endothelial migration cells, suggesting that they may act as anti‐inflammatory anti‐tumour agents. Here we have evaluated effects cholbut on cell growth using in vitro vivo models. Experimental Approach Cholbut s were incubated with cultures four lines, was analysed by assessing...
Critically ill patients present reduced endogenous melatonin blood levels, and they might benefit from its exogenous supplementation. The aim of this research was to evaluate the feasibility different routes administration drug formulations melatonin. efficiency absorption assessed as well adequacy in achieving maintaining physiological nocturnal peak.Twenty-one high-risk critically were randomly assigned receive either: (a) per os, a standard tablet (ST-OS), (b) suspension solid lipid...
Nanoemulsions (NEs) have been extensively studied as carriers for drug delivery, since these provide a good alternative to the existing non-nano systems, while promoting their target delivery and controlled release. NEs are considered safe from pre-clinical perspective, but there is currently no information on ecotoxicological effects. In present study we investigated toxicity of NE material (lecithin, sunflower oil, borate buffer) designed be used liposomal excipient eye drops, further...