A5019212457- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Nanoplatforms for cancer theranostics
- Boron Compounds in Chemistry
- Advanced X-ray and CT Imaging
- Innovations in Medical Education
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Health and Medical Research Impacts
- Medical Imaging Techniques and Applications
- Ultrasound in Clinical Applications
- Vascular Procedures and Complications
- Radiology practices and education
- Cardiac Imaging and Diagnostics
- Nuclear Physics and Applications
- Ubiquitin and proteasome pathways
- Effects of Radiation Exposure
- Health and Well-being Studies
- Phytochemicals and Medicinal Plants
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Stress, Anesthesia, and Immune Response
- Medicinal Plant Research
- Polymer Nanocomposite Synthesis and Irradiation
Tabriz University of Medical Sciences
2014-2025
Biotechnology Research Center
2024
Imam Reza Hospital
2015-2023
University of Tabriz
2018-2023
Leicester Royal Infirmary
1999-2000
Ninewells Hospital
1997
Colon carcinoma poses a significant health challenge globally, particularly in developed nations where sedentary lifestyles, poor dietary choices, and genetic factors play crucial role its prevalence. Chemotherapy, the primary treatment method, carries severe side effects that can jeopardize patients' lives. Herbal extracts such as Ocimum Basillicum extract have shown effectiveness against cancer cells. Additionally, nanoparticles significantly enhance drug delivery efficacy these scenarios.
Current methods of colon cancer treatment, especially chemotherapy, require new treatment due to adverse side effects. One important area interest in recent years is the use nanoparticles as drug delivery vehicles since several studies have revealed that they can improve target specificity thus lowering dosage drugs while preserving effectiveness reducing The traditional medicine has also been a favorite topic medical research, research. In this research work, green synthesis Fe was carried...
The development of high-Z based metallic nanomaterials as radiosensitizers are limited due to having some challenges such nonideal selectivity the target tissue. In this work, we prepared X-ray triggered Bi2S3-Au heterodimers with a Schottky barrier and hopeful capability generation free radicals for selectively improving radiotherapeutic efficacy in tumors via not complicated environmentally friendly methods. We explain use folic acid (FA) functionalized, BSA-modified (i.e., Bi2S3-Au-BSA-FA...
Abstract Magnetic silver nanoparticles are intelligent magnetic particles that have high intelligence and a large absorption surface area. Their small size wide make them effective drug carriers to the cancer site. In this research, properties of green formulation by Anethum graveolens on colon carcinoma cells were checked. The Ag‐bionanoparticles synthesized using underwent characterization through FT‐IR, XRD, EDS‐mapping, SEM techniques. aim work is study decrease in cell viability BCL2...
An investigation has been carried out into the properties of BANG polymer gel and its use in dosimetry low dose rate brachytherapy. It was discovered that response reproducible linear to 10 Gy. The found be tissue equivalent with a independent energy within experimental accuracy (standard error measurement +/- 5%). slope calibration curve increase from 0.28 0.01 s-1 Gy-1 0.50 0.02 for an monomer concentration 6 9%. Absorbed distributions straight applicator containing 36 137Cs sources were...
Introduction: The present study was done to assess the effect of molecularly-targeted core/shell iron oxide/gold nanoparticles (Fe3O4@AuNPs) on tumor radiosensitization SKBr-3 breast cancer cells. Methods: Human epidermal growth factor receptor-2 (HER-2)-targeted Fe3O4@AuNPs were synthesized by conjugating trastuzumab (TZ, Herceptin) PEGylated (PEG)-Fe3O4@AuNPs (41.5 nm). First, Fe3O4@Au core-shell NPs decorated with PEG-SH synthesize PEG-Fe3O4@AuNPs. Then, TZ reacted OPSS-PEG-SVA conjugate...
Polymer gels with and without 60 ppm of 10B were exposed to an epithermal neutron beam produced by the Dynamitron at University Birmingham on two separate occasions. Eight vials containing gel, four boron, irradiated in pairs a water phantom for 5 h. The maximum dose was calculated be 9 Gy A-150 tissue equivalent plastic, 4 cm deep phantom. Measurements made variation relaxation rates depth These compared calculations using MCNP Monte Carlo program gel response followed general trend results...
Purpose: Two-deoxy-D-glucose (2DG) causes cytotoxicity in the cancer cells by disrupting thiol metabolism, and MLN4924 inactivates SCF E3 ligase so accumulation of its substrates which trigger apoptosis hence might enhance efficiency radiotherapy overcame on radioresistance cells. Materials methods: SKBR3 MCF-7 breast were treated with 500 μM 2DG and/or (30, 100, 200 300 nM), combination presence absence 1, 1.5 2 Gy gamma irradiation. The effects treatments – 2DG, MLN4924, irradiation alone...
Recently it has been shown that radiation dose enhancement could be achievable in radiotherapy using nanoparticles (NPs). In this study, evaluation was made to determine efficiency of gold-silica shell-core NP megavoltage irradiation MCF7 breath cancer cells.Gold-silicon oxide NPs were obtained by conjugation gold with amine or thiol functionalized silica (AuN@SiO2 and AuS@SiO2). Cellular uptake cytotoxicity examined fluorescent microscopy MTT assay, respectively. MCF-7 breast cells treated...
2-deoxy-D-Glucose (2DG) causes cytotoxicity in cancer cells by disrupting thiol metabolism. It is an effective component therapeutic strategies. targets the metabolism of with glycolysis inhibitory activity. On other hand, MLN4924, a newly discovered investigational small molecule inhibitor NAE (NEDD8 activating enzyme), inactivates SCF E3 ligase and accumulation its substrates which triggers apoptosis. Combination these components might provide more efficient approach to treatment. In this...
Doxorubicin (DOX) was introduced as an effective chemotherapeutic for a wide range of cancers but with some severe side effects especially on myocardia. 2-Deoxy-D-glucose (2DG) enhances the damage caused by chemotherapeutics and ionizing radiation (IR) selectively in cancer cells. We have studied 1μM DOX 500 μM 2DG induced cell death, apoptosis also expression levels p53 PTEN genes T47D SKBR3 breast cells irradiated 100, 150 200 cGy x-rays. treatments resulted altered radiation-induced well...
Human double minute2 (hdm2) level increases in most human malignancies. Therefore, inhibition of tumor growth and also induction radiosensitivity may be provided by hdm2 inhibitors. The effects hdm2-siRNA on protein expression, cell apoptosis rate, esophageal squamous carcinoma (ESCC) were studied.The gene was silenced TE1, TE8, TE11 ESCC lines using 200nM siRNA liposomal transfection method followed irradiation with 0.5, 1, 2, 4, 6 Gy γ-rays vitro. expression levels evaluated real time PCR...
To review the knowledge of radiographers and examine possible sociodemographic situational contributors to this knowledge.A questionnaire survey was devised distributed a cohort 120 radiographers. Each contained two sections. In first section, background data, including sex, age, highest academic level, grade point average (GPA), length time from graduation, work experience as radiographer status previous refresher course(s), were collected. The second section 17 multiple-choice questions...
We aimed to determine angiography projections with lower Dose Area Product (DAP) rate by measuring the mean DAP and fluoroscopy times in coronary (CAG) percutaneous intervention (PCI) calculating different projections.DAP were measured all employed real-time 75 patients who underwent CAG or PCI a single cardiologist Madani Cardiovascular University Hospital (45 group 30 group). was calculated both groups projections. The highest lowest determined.Mean 436.73±315.85 dGy×cm(2) 643.26±359.58...
Comparison of different Monte Carlo codes for understanding their limitations is essential to avoid systematic errors in the simulation, and suggest further improvement codes. MCNP4C EGSnrc, two commonly used medical physics, were compared evaluated against electron depth-dose data experimental results obtained using clinical radiotherapy beams. Different physical models algorithms give significantly curves. The default version calculates curves which are too much penetrating. agree better...