A5055858348- Wound Healing and Treatments
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Neuroscience of respiration and sleep
- Radiomics and Machine Learning in Medical Imaging
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Electrospun Nanofibers in Biomedical Applications
- Epigenetics and DNA Methylation
- Corneal Surgery and Treatments
- Nausea and vomiting management
- Advanced X-ray and CT Imaging
- Galectins and Cancer Biology
- Lung Cancer Diagnosis and Treatment
- Folate and B Vitamins Research
- Electron Spin Resonance Studies
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Spinal Cord Injury Research
- Peptidase Inhibition and Analysis
- Pathogenesis and Treatment of Hiccups
- Lung Cancer Treatments and Mutations
Zunyi Medical University
2015-2025
Qingdao University
2009-2017
Yantai Laiyang Central Hospital
2017
Shanxi Fenyang Hospital
2016
Shanxi Medical University
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2016
Abstract Background Wound healing is a complex pathophysiological process that involves variety of cells and cytokines. In this study, we found local injection human amnion mesenchymal stem into wounds in rats could promote wound healing. Therefore, hypothesized the exosomes contain substances regulate migration epidermal cells. It has been reported miR-135a involved cell transformation. However, there have no reports its function skin Methods To test hypothesis, injected overexpressing...
Diabetic wound is the leading cause of non-traumatic amputations in which oxidative stress and chronic inflammation are main factors affecting healing. Although mesenchymal stem cells (MSCs) as living materials can promote skin regeneration, they still vulnerable to limits their clinical applications. Herein, we have prepared (polylactic-co-glycolic acid) (PLGA) nanofibers electrospun with LPS/IFN-γ activated macrophage cell membrane. After defining physicochemical properties modified by...
Objective. Malignant melanoma (MM) is one of the most malignant types skin cancer and its incidence mortality rates are increasing worldwide. Aging well recognized as a significant risk factor for cancer. However, few studies have analyzed in depth association between aging-related genes (AGs) prognosis with tumor immune microenvironment. Methods. Here, we downloaded 471 MM patients from The Cancer Genome Atlas (TCGA) RNA sequence clinicopathological data. 58 AGs TCGA dataset were examined...
Nowadays, chemotherapy induced nausea and vomiting (CINV) is still common in patients with cancer. It was reported that substance P mediated CINV via neurokinin-1 (NK1 ) receptor antagonists of NK1 has been proved useful for treating but the mechanism are not fully understood. This study aimed to examine role blocker, CP-99 994, when administrated into dorsal motor nucleus vagus (DMNV), on cisplatin-induced emesis rats possible mechanism.Rats' kaolin intake, food bodyweight were recorded...
Background Intestinal motilin is known to stimulate gastrointestinal (GI) motility and the arcuate nucleus (Arc) of hypothalamus shown be involved in regulation GI motility. Methods Single unit discharges Arc were recorded extracellularly by implantation a force transducer into stomach rats, evaluate effect on gastric Projection nerve fiber expression observed retrograde tracer deposits Fluoro-Gold (FG) fluo-immunohistochemistry staining. Key Results 65.5% neurons responded distension (GD),...
Motilin, an important endocrine regulator of gastrointestinal motility, was once considered to be produced in the tract and brain. In recent years, however, motilin has been found human thyroid, as well that guinea pig. The physiological function central modulation thyroidal remain poorly understood. To determine functional role motilin, we observed concentration plasma also gastric motility before after thyroidectomy. Our studies show both were decreased explore modulation-related nuclei, a...
To investigate the effect of microRNA-135a (miR-135a) in human amnion mesenchymal stem cell exosome (hAMSC-Exo) on migration fibroblasts.The hAMSC-Exo was extracted with exosomes separation kit and identified, fibroblasts detected by scratch test. Real-time fluorescence quantitative PCR (qRT-PCR) used to detect relative expression miR-135a gene after overexpression miR-135a. Scratch test knockdown Western blot related proteins [large tumor suppressor 2 (LATS2), E-cadherin, N-cadherin, α...
To investigate the effects and related mechanism of 5-aza-2'-deoxycytidine(Aza) on endothelial function in Hyperhomocysteinemia rats.Adult male SD rats were divided into 3 groups (n=7 each): control group, hyperhomocysteinemia (HHcy) group Aza according to random number table. Control fed with normal diet. HHcy diet adding 3% L-methionine. L-methionine (0.5 mg/kg) injection for consecutive three days per week 8 weeks. After weeks, content rat plasma homocysteine (Hcy) was detected by enzyme...
Abstract Diabetic wound is the leading cause of non-traumatic amputations in which oxidative stress and chronic inflammation are main factors affecting healing. Although conventional mesenchymal stem cells (MSCs) living material can promote skin regeneration, they still vulnerable to limits their clinical applications. Here, we have prepared (lactic-co-glycolic acid) (PLGA) nanofibers electrospun with LPS/IFN-γ activated macrophage cell membrane capacity immunostimulate bone marrow derived...
Concurrent chemo-radiotherapy is a new way to treat paitents with brain metastases from lung cancer.The blood-brian barrier can be opened more widely by whole radiotherapy,then the chemotheropy drugs promoted into metastases,and local concentration increased.Some chemotherapy get tissue through distructed in some studies.At same time and radiotherapy interact each other progress of treatment.Some clinic trials have had conclusion that concurrent increase short term response rate prolong...
Objective To compare the clinical value of radiotherapy and concurrent chemoradiotherapy in elderly patients with advanced non-small cell lung cancer (NSCLC). Methods Ninety-eight NSCLC were randomly divided into observation group control 49 cases esch group. The received alone, treated by chemoradiotherapy. efficacy adverse reaction two groups observed analyzed. Results The total effective rate treatment (65.31%) was significantly higher than that (34.69%), difference...