A5019736805- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
- GDF15 and Related Biomarkers
- Biomarkers in Disease Mechanisms
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Genomics and Rare Diseases
- Heart Rate Variability and Autonomic Control
- Pancreatic and Hepatic Oncology Research
- FOXO transcription factor regulation
- S100 Proteins and Annexins
- Macrophage Migration Inhibitory Factor
- vaccines and immunoinformatics approaches
- Healthcare Systems and Public Health
- Tryptophan and brain disorders
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Impact on Reproduction
- PARP inhibition in cancer therapy
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Blood properties and coagulation
- Machine Learning in Bioinformatics
- Immune responses and vaccinations
City Hospital No. 40
2019-2025
St Petersburg University
2021-2025
St. Petersburg State Medical Academy "City Hospital No. 26"
2023
Saint Petersburg State Pediatric Medical University
2008-2009
Aim. To determine the prognostic significance of left atrial (LA) changes after SARS-CoV-2 infection on fibrillation recurrence rate catheter ablation. Material and methods . The study involved 40 patients. All patients were monitored 3, 6 12 months, as well when clinical performance disease changed. average follow-up time was 19±3 months. Recurrence observed in 18 (45%). Results groups completely comparable age (p=0,382), sex (p=0,604), arrhythmia type (p=0,842), history previous surgeries...
Background/Objectives: The COVID-19 pandemic has posed a significant challenge to global healthcare systems and prompted need for better understanding of the molecular mechanisms underlying SARS-CoV-2 infection. This study aims analyze differential gene expression in patients identify regulatory genes influencing key pathways involved disease progression. Methods: We conducted transcriptomic analysis admitted Infectious Disease Department City Hospital No. 40, confirmed with via PCR....
Objective A critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory response, caused overproduction of proinflammatory cytokines, known as “a cytokine storm” (CS), strongly associated with severe course disease. The aim this study identify prognostic biomarkers for CS development COVID-19 patients and integrate them into score CS-associated risk applicable routine clinical practice....
The COVID-19 pandemic has drawn the attention of many researchers to interaction between pathogen and host genomes. Over last two years, numerous studies have been conducted identify genetic risk factors that predict severity outcome. However, such an analysis might be complicated in cohorts limited size and/or case breadth genome coverage. In this work, we tried circumvent these challenges by searching for candidate genes variants associated with a variety quantitative binary traits cohort...
BACKGROUND: Human genotype is a factor that determines the severity of COVID-19. Previously, large-scale whole-genome association study COVID-19 Host Genetics Initiative (2021) investigated genetic variants at multiple loci with severity. The have greatest effect on are expected to low frequency in population. Therefore, rare may provide additional insights into disease pathogenesis and thus help development prevention treatment options. AIM: To search for genes enriched associated Russian...
Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety ways. To date, however, vast majority research has been devoted to study leukocytes, while erythrocyte changes have received significantly less attention. The aim this was identify morphology abnormalities that occur COVID-19, compare number different poikilocyte types, measure sizes provide data on size dispersion. Red obtained from 6 control donors (800-2200 per donor) 5 patients...
Inflammation, cardiac remodeling, and fibrosis are potentially important pathways in the pathogenesis of cardiovascular diseases. Complications atherosclerosis one leading causes death world. Effective prevention disease by adequate control major risk factors can provide substantial public health gains. However, detection continues to be a challenge because poor awareness an individual's status. A solution this problem is for early identification appropriate correction factors....
Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety ways. To date, however, vast majority research has been devoted to study leukocytes, while erythrocyte changes have received significantly less attention. The purpose this was identify types that were unique COVID-19, compare number different poikilocyte types, measure sizes provide data on size dispersion. Red obtained from 6 control donors (800-2200 for each donor) 5 patients (800-1900...
Aim . Using a collection of samples from the biobank ofCityHospital № 40 ofSt. Petersburg, to study cytokine profile in patients with coronavirus disease 2019 (COVID-19) and sepsis, comparison abdominal inflammation septicemia. Material methods. The included serum 181 sepsis COVID-19 (127 diagnosis confirmed by polymerase chain reaction (PCR); 54 negative PCR test, but characteristic computed tomographic lung performance) 47 sepsis. content cytokines was determined using multiplex...
BACKGROUND: Analysis of the effect comorbid diseases on concentration biomarkers will help to deepen understanding pathogenetic mechanisms impact course COVID-19 and adjust prognostic models for its therapy.
 AIM: To study severity outcomes COVID-19. In addition, an analysis levels macrophage-derived chemokine, interferon-γ-induced protein 10 kD, soluble CD40 ligand, vascular endothelial growth factor has been carried out in 472 patients with COVID-19, depending presence various forms...
BACKGROUND: An important feature of COVID-19 is the development pronounced hypercoagulation with an increased risk thrombotic damage to pulmonary vascular bed, mainly arteries. Thrombosis blood vessels causes a local violation hemodynamics hyperemia, edema, which leads decrease in ventilation lung tissue area and serves as one respiratory failure. AIM: This study aimed conduct morphological morphometric analysis bed tissues deceased severe extremely forms new coronavirus infection who were...
ABSTRACT The course of COVID-19 is characterized by wide variability, with genetics playing a contributing role. Through large-scale genetic association studies, significant link between variants and disease severity was established. However, individual identified thus far have shown modest effects, indicating polygenic nature this trait. To address this, risk score (PRS) can be employed to aggregate the effects multiple single nucleotide polymorphisms (SNPs) into number, allowing practical...
The COVID-19 pandemic has created unique challenges for people with comorbidities, including hereditary diseases and cancer cancers. Several studies have reported a link between the presence of disease-causing genetic variants outcome infection. In this study, we used clinical exome sequencing in cohort 840 patients to identify pathogenic likely present these individuals. While did not any statistically significant differences overall burden different patient groups, discovered three known...
Aim . To determine the reference ranges of concentrations 38 cytokines, chemokines and growth factors, as well to measure content these analytes in patients with neurodegenerative cardiovascular diseases (CVDs) using biomaterial from biobank repository. Material methods The study included 303 serum plasma samples 281 healthy donors, 242 224 diseases, 164 152 CVDs St. Petersburg City Hospital № 40. In all samples, concentration chemokines, factors was determined by multiplex...
Background: According to WHO, as of March 31, 2021, 127 877 462 confirmed cases the new COVID-19 coronavirus infection were registered in world, including 2 796 561 deaths (WHO Coronavirus Disease). is characterized by a wide range clinical manifestations, from asymptomatic rapid progression severe and extremely severe. Predictive biomarkers for early detection high-risk individuals have become matter great medical urgency. Aims: Search predictors cytokine storm patients with creation risk...
Evidence for genetic polymophisms may contribute to the dependence on sex and age differences in biochemical phenotypes, clinical manifestation, severity success medical treatment of coronary artery disease (CAD) comes from a variety studies. Two polymorphisms, L55M Q192R, human antioxidant system paraoxonase 1 gene (PON1) have been shown be associated with increased risk CAD. The aim recent study was investigate possible association between polymorphic variants PON1 CAD patients different...
The identification of new SARS-CoV-2 and human protein gene targets, which may be markers the severity outcome disease, are extremely important during COVID-19 pandemic. goal this study was to carry out genetic analysis RNA samples elucidate correlations parameters (SNPs) with clinical data infection. Material Methods. included viral isolated from 56 patients infection who received treatment at City Hospital No. 40 St. Petersburg 04/18/2020 04/18/2021. Patients underwent physical examination...
Влияние специфического Т-клеточного и гуморального иммунного ответа к SARS-CoV-2 на выживаемость пациентов, впервые болеющих COVID-19 1 Санкт-Петербургское государственное бюджетное учреждение здравоохранения «Городская больница № 40 Курортного района» Отдела администрации района г.Санкт-Петербурга, 197706, г.Сестрорецк, Российская Федерация 2 Федеральное образовательное высшего образования «Санкт-Петербургский государственный университет», 199034, г.Санкт-Петербург, 3...
ABSTRACT The course of COVID-19 is determined by various factors. Studies worldwide have shown a correlation between changes in the expression profile and severity disease. Thus, an in-depth study differentially expressed genes will allow more detailed investigation metabolic occurring background coronavirus infection. technique RNA sequencing subsequent bioinformatics analysis suitable for such research tasks. In our study, we compared groups samples from patients with mild severe disease...
Aim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical laboratory history. Studying relationship between severity COVID-19 symptoms concentration primary metabolites, primarily amino acids. Material . The retrospective study included serum samples from a total 935 people (445 men 490 women) collection biobank City Hospital № 40. A was studied in all chromatography-mass spectrometry. R...
Clinical aspects, risk factors, results of selective coronary angiography, features DNA-polymorphism (I/D polymorphism gene ACE, isoalleles APOE, SsTI АРОСЗ, С677Т MTHFR, 4a/4b, G894T and T786C polymorphisms eNOs) in 89 women with a various degree obstruction. In patients sings artery atherosclerosis, familial history i heart disease was observed most cases (greater on line mother). The obtained data show the reliable role allele T, genotype CT MTHFRand gene-gene interaction ACE MTHFR genes...