A5053551781- interferon and immune responses
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Photorefractive and Nonlinear Optics
- Cancer-related molecular mechanisms research
- Cellular transport and secretion
- Molecular Sensors and Ion Detection
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Heme Oxygenase-1 and Carbon Monoxide
- Cytokine Signaling Pathways and Interactions
- Genetic Neurodegenerative Diseases
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Advancements in Semiconductor Devices and Circuit Design
- RNA Research and Splicing
- Genetics and Physical Performance
- Nanocluster Synthesis and Applications
- Autophagy in Disease and Therapy
- Aluminum toxicity and tolerance in plants and animals
- Semiconductor materials and devices
- RNA and protein synthesis mechanisms
- Congenital heart defects research
- Metal complexes synthesis and properties
Foshan University
2024
University Hospital Cologne
2024
University of Cologne
2024
Lanzhou Jiaotong University
2023
Shandong Academy of Agricultural Sciences
2023
Shandong Normal University
2023
Hunan Normal University
2012-2021
Abstract Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin and etoposide recently combined with PD-L1 inhibitors. Yet, in most cases, SCLC patients develop resistance first-line therapy alternative therapies are urgently required overcome this resistance. In study, we tested the efficacy dinaciclib, an FDA-orphan drug inhibitor cyclin-dependent kinase (CDK) 9, among other CDKs, SCLC. Furthermore, report on a newly...
Apoptosis is a widespread phenomenon and its dysregulation may result in variety of human pathologies, such as cancer, autoimmune diseases neurodegenerative disorders. CXXC-type zinc finger protein 5 (CXXC5) commonly considered tumor suppressor undergoing deregulation or deletion hematonosis. But it has implied involvement apoptosis indirectly the molecular mechanism remains unknown. In this study, we investigated CXXC5-induced well underlying mechanism. A fluorescence resonance energy...
Background: Previously, we showed that the Zinc finger-containing transcription factor ZNF424 inhibits p21 transcription, which has been widely associated with various cancers. However, because roles of in tumorigenesis have not characterized, correlated expression lung cancer. Results: The present immunohistochemical analyses show significantly lower levels 43 60 cancer tissues compared adjacent tissues. Moreover, flow cytometry assays indicated overexpression induces apoptosis A549 human...
Silica (SiO2) strip-loaded waveguides and Y-junctions on lithium niobate (LN) thin film were designed, fabricated experimentally investigated. We first studied the optical confinement factor distribution in waveguides. The Simulations showed that most of power (>82%) was confined LN layer, dimensions SiO2 loading strip had a relatively small influence distribution. deposited with magnetron sputtering method. layer approached stoichiometric SiO2, smooth surface obtained. A group widths 2–5 μm...
Background: The basic helix-loop-helix (bHLH) protein families are a large class of transcription factors, which associated with cell proliferation, tissue differentiation, and other important development processes. We reported that the Nuclear localized protein-1 (Nulp1) might act as novel bHLH transcriptional factor to mediate cellular functions. However, its role in vivo remains unknown. Methods: Nulp1 (dNulp1) mutants generated by CRISPR/Cas9 targeting Domain Unknown Function (DUF654) C...
Reproduction, Fertility and Development is an international journal publishing original research , review comment in the fields of reproduction developmental biology humans, domestic animals wildlife
The assembly of LIM-homeodomain (LIM-HD) transcriptional complex plays important roles in early neuronal development. stability LIM-HD is controlled by single-strand binding protein 3 (SSBP3) via a cascade mechanism protecting it from proteasomal degradation. expression level SSBP3 has to be precisely regulated. Although decrease associated with several diseases, the downregulation and whether itself subject degradation remain largely unknown. Two strongly conserved transcripts gene, SSBP3a...