A5005302025- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Lymphatic System and Diseases
- Trace Elements in Health
- Colorectal Cancer Screening and Detection
- Primate Behavior and Ecology
- Inhalation and Respiratory Drug Delivery
- Carcinogens and Genotoxicity Assessment
- Monoclonal and Polyclonal Antibodies Research
- Bird parasitology and diseases
- Bacteriophages and microbial interactions
- AI in cancer detection
- Magnesium in Health and Disease
- Animal Nutrition and Physiology
- Heavy Metal Exposure and Toxicity
- Therapeutic Uses of Natural Elements
- Noise Effects and Management
Ashland (United States)
2020-2023
Charles River Laboratories (United States)
2020-2023
The University of Texas MD Anderson Cancer Center
2017-2020
SLC30A10 and SLC39A14 are manganese efflux influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary toxicity. Patients have elevated the blood brain develop neurotoxicity. Liver is increased patients lacking but not SLC39A14. These organ-specific changes were recently recapitulated knockout mice. Surprisingly, Slc30a10 knockouts also had thyroid developed hypothyroidism. To determine mechanisms of manganese-induced hypothyroidism...
Colorectal cancer accounts for a substantial number of deaths each year worldwide.Lynch Syndrome is genetic form colorectal (CRC) caused by inherited mutations in DNA mismatch repair (MMR) genes.Although researchers have developed mouse models Lynch through targeted mutagenesis MMR genes, the tumors that result differ important ways from those patients.We identified 60 cases CRC rhesus macaques (Macaca mulatta) at our facility since 2001.The occur ileocecal junction, cecum and proximal colon...
Colorectal cancer (CRC) remains the third most common in US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation MLH1 promoter. A cohort rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC a notable fraction harboring pathogenic germline mutation (c.1029C<G, p.Tyr343Ter). Our study aimed provide detailed molecular characterization for cross-comparison human MMRd CRC. We...
In Tg-rasH2 carcinogenicity mouse models, a positive control group is treated with carcinogen such as urethane or N-nitroso-N-methylurea to test study validity based on the presence of expected proliferative lesions in transgenic mice. We hypothesized that artificial intelligence–based deep learning (DL) could provide decision support for toxicologic pathologist by screening changes, verifying pattern groups. Whole slide images (WSIs) lungs, thymus, and stomach from groups were used...
Owl monkeys are small nocturnal new world primates in the genus
Abstract Colorectal cancer (CRC) remains the third most common in US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation MLH1 promoter. A cohort rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC a notable fraction harboring pathogenic germline mutation (c.1029C<G, p.Tyr343Ter). Our study incorporated detailed molecular characterization for cross-comparison human MMRd CRC....