A5030149598- Cardiac Valve Diseases and Treatments
- Sports Performance and Training
- Infective Endocarditis Diagnosis and Management
- Physical Education and Training Studies
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Pancreatic function and diabetes
- Neuroscience and Neural Engineering
- Sports injuries and prevention
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Pluripotent Stem Cells Research
- Acute Myocardial Infarction Research
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and exercise physiology
- Erythrocyte Function and Pathophysiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal cell carcinoma treatment
- CRISPR and Genetic Engineering
- Education and Learning Interventions
- Blood properties and coagulation
University of Opole
2020-2024
Jagiellonian University
2004-2023
Institute of Cardiology
2016-2023
Maria Curie-Skłodowska University
2014-2022
ETH Zurich
2020-2021
Uniwersytecki Szpital Kliniczny w Opolu
2021
John Paul II Hospital
2016-2019
Corona (Poland)
2019
Malmö University
2016
Adam Mickiewicz University in Poznań
2001
Electronic control of designer cells There is increasing interest in using to produce or deliver therapeutics. Achieving direct communication between such and electronic devices would allow precise therapies. Krawczyk et al. describe a bioelectronic interface that uses wireless-powered electrical stimulation promote the release insulin (see Perspective by Brier Dordick). The authors engineered human β respond membrane depolarization rapidly releasing from intracellular storage vesicles. A...
Abstract Rewiring cellular sensors to trigger non-natural responses is fundamental for therapeutic cell engineering. Current designs rely on engineered receptors that are limited single inputs, and often suffer from high leakiness low fold induction. Here, we present Generalized Engineered Activation Regulators (GEARs) overcome these limitations by being pathway-specific rather than input-specific. GEARs consist of the MS2 bacteriophage coat protein fused regulatory or transactivation...
Abstract Body temperature is maintained at around 37 °C in humans, but may rise to 40 or more during high‐grade fever, which occurs most adults who are seriously ill. However, endogenous sensors, such as ion channels and heat‐shock promoters, fully activated only noxious temperatures above this range, making them unsuitable for medical applications. Here, a genetically encoded protein thermometer (human enhanced gene activation thermometer; HEAT) designed that can trigger transgene...
The aim of the study was to investigate effects eight weeks regular physical education classes supplemented with high intensity interval cycle exercise (HIIE) or continuous exercises moderate (CME).Forty-eight collegiate females exercising in two per week were randomly assigned programmes (HIIE; n=24 CME; n=24) additional (one session 63 minutes week) activity for 8 weeks.Participants performed HIIE comprising 2 series 6x10 s sprinting maximal pedalling cadence and active recovery 65%-75% HR...
The digit ratio (2D:4D) is said to be a potential marker of exposure prenatal sex steroids. Some studies suggest that the 2D:4D also linked with testosterone response challenging situations due organizational effect hormonal milieu on adult endocrine functioning. However, up date, there were only four (conducted small samples) examined and situation (i.e. physical exertion or aggressive context). Here, we relationship between change under an acute exercise among 97 men. We found ratios (the...
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an established management strategy for severe stenosis. Percutaneous axillary approach TAVI holds the promise of improving safety without jeopardizing effectiveness in comparison to surgical access. We aimed at appraising comparative percutaneous vs. approaches TAVI.METHODS: performed international retrospective observational study using de-identified details on baseline, procedural, and 1-month follow-up features. Valve Academic...
1. Löllgen H, Böckenhoff A, Knapp G. Physical activity and all-cause mortality: an updated meta-analysis with different intensity categories. Int J Sports Med. 2009; 30(3): 213–224. CrossRef Google Scholar
Abstract Percutaneous transaxillary approach (PTAX) through the first segment of axillary artery is not widely recognized as a safe method. Furthermore, PTAX has never been directly compared between Impella-supported percutaneous coronary interventions (Impella-PCI) and transcatheter aortic valve replacement (TAVR). This study evaluated feasibility safety in Impella-PCI versus TAVR. In cases where standard imaging guidance was insufficient, technique involving puncturing “on-the-balloon”...
Managing complex coronary artery disease (CAD) in elderly patients with coexisting severe aortic stenosis and peripheral arterial can pose a significant challenge, particularly when complicated by acute syndrome (ACS).Percutaneous intervention (PCI) is often the preferred revascularization therapy these situations, frequently accompanied balloon valvuloplasty (BAV) [1, 2].However, for left main (LMS), poor ventricular function, multiple comorbidities, PCI carries high risk may require...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Krawczyk K, Stepien Nowak Nessler J, Zalewski J. ST-segment re-elevation following primary angioplasty in acute myocardial infarction with patent infarct-related artery: impact on left ventricular function recovery and remodeling. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2019;15(4):412-421. doi:10.5114/aic.2019.90215. APA Krawczyk, K., Stepien, Nowak, Nessler, J., & Zalewski,...
In humans, cellular mechanoperception serves as the basis of touch sensation and proprioception, contributes to proper programming cell fate during embryonic development, plays a pivotal role in development mechanosensitive tissues. Molecular mechanoreceptors can respond their environment by mediating transient adjustments ion homeostasis, which subsequently trigger calcium-dependent alteration gene expression via specific signaling pathways such nuclear factor activated T-cells pathway....
Despite advances in the treatment of heart failure (HF), rate hospitalisation for exacerbations disease remains high. One underlying reasons is that recommended guidelines management HF are still too rarely followed daily practice. Disease exacerbation requiring inpatient always afactor worsens prognosis, and thus signals progression. This also akey moment when therapy should be modified exacerbation, or initiated case newly diagnosed disease. Inpatient peri‑discharge period time aetiology...
Recent improvements in optimal cardiovascular therapy have questioned the beneficial effects of polyunsaturated fatty acids (PUFAs) observed previous studies.We investigated acid (FA) composition serum phospholipids patients with an established acute phase myocardial infarction (MI) and high‑risk stable atherosclerotic disease (CVD).We studied 83 hospitalized within 12 hours from onset first clinical symptoms MI. As a control group, we assessed 74 at high risk CVD treated outpatient...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Sacha J, Krawczyk K, Gierlotka M. Fully percutaneous insertion and removal of the Impella CP via a subclavian approach. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2020;16(3):343-346. doi:10.5114/aic.2020.99273. APA Sacha, J., Krawczyk, K., & Gierlotka, (2020). Interwencyjnej, 16(3), 343-346. https://doi.org/10.5114/aic.2020.99273 Chicago Jerzy, Krzysztof Marek Gierlotka. 2020....
The purpose of this study was to evaluate the prevalence syncope induced by head-up tilt test (HUTT) and type positive vasovagal response orthostatic stress in a relationship estimated phase menstrual cycle (follicular phase, luteal phase) or menopause.We observed cohort 500 women at age 13-89 years (median 37.5), referred HUTT. Phase determined on basis usual length day time study. We assumed that is constant it 14 days.In premenopausal patients, occurrence mixed cardioinhibitory...
University education is a period of human life when lifestyles or person's activity are critical to the development somatic build, while identification somatotype allows for corrections recommendation effective physical programmes. The main aim this study was assess selected features body build and identify somatotypes young people at early stages Jozef Pilsudski Physical Education in Warsaw depending on field study. examined 394 students (PE) sport (S). Anthropometric measurements were...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Sacha J, Krawczyk K, Gwóźdź W, Bugajski Darmetko M, Gierlotka M. Cusp overlap technique for transcatheter self-expanding aortic valve implantation. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2021;17(2):230-231. doi:10.5114/aic.2021.107509. APA Sacha, J., Krawczyk, K., Gwóźdź, W., Bugajski, Darmetko, M., & Gierlotka, (2021). Interwencyjnej, 17(2), 230-231....
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Sacha J, Krawczyk K, Gawor M, PÅonka Gierlotka M. Balloon aortic valvuloplasty, Impella insertion and complex coronary intervention: is this all feasible fully percutaneously via upper limb access?. Advances in Interventional Cardiology/PostÄpy w Kardiologii Interwencyjnej. 2021;17(1):126-128. doi:10.5114/aic.2021.104783. APA Sacha, J., Krawczyk, K., Gawor, M., PÅonka, & Gierlotka, (2021). Interwencyjnej,...
Abstract The kidney is a complex but highly structured organ composed of more than 20 different cell types. Disturbances among these types leads to plethora diseases acute or chronic type, some which are life threatening. In addition, cancer represents about 3 percent all malignancies. Considerable efforts have been made profile the kidney. However, mainly based on studies in rodents. current study we present method, called composition cellular stratification that define gene signatures...