A5083181517- Noise Effects and Management
- Heavy Metal Exposure and Toxicity
- Urban Green Space and Health
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Dementia and Cognitive Impairment Research
- Child and Adolescent Psychosocial and Emotional Development
- Health disparities and outcomes
- Child Abuse and Trauma
- Homelessness and Social Issues
- Functional Brain Connectivity Studies
- Land Use and Ecosystem Services
- Trace Elements in Health
- Migration, Health and Trauma
- Mercury impact and mitigation studies
- Global Health Workforce Issues
- Epigenetics and DNA Methylation
- Child Nutrition and Water Access
- Environmental Justice and Health Disparities
- Memory and Neural Mechanisms
- Heavy metals in environment
- Neural and Behavioral Psychology Studies
- Urban Heat Island Mitigation
- Healthcare professionals’ stress and burnout
University of Virginia
2025
Duke University
2016-2024
Medical University of South Carolina
2022-2024
Harvard University
2023
Yale University
2021
Berkeley College
2021
University of California, Berkeley
2021
Columbia University
2009-2011
Royal College of Physicians
2010
Columbia College
2010
Background Adverse childhood experiences ( ACE s; e.g. abuse, neglect, and parental loss) have been associated with increased risk for later‐life disease dysfunction using adults’ retrospective self‐reports of s. Research should test whether associations between s health outcomes are the same prospective measures. Methods We estimated agreement prospectively recorded throughout (by Study staff at member ages 3, 5, 7, 9, 11, 13, 15) retrospectively recalled in adulthood members when they...
<h3>Importance</h3> Mental health professionals typically encounter patients at 1 point in patients’ lives. This cross-sectional window understandably fosters focus on the current presenting diagnosis. Research programs, treatment protocols, specialist clinics, and journals are oriented to diagnoses, assumption that diagnosis informs about causes prognosis. study tests an alternative hypothesis: people with mental disorders experience many different kinds of across diagnostic families, when...
<h3>Importance</h3> Many children in the United States and around world are exposed to lead, a developmental neurotoxin. The long-term cognitive socioeconomic consequences of lead exposure uncertain. <h3>Objective</h3> To test hypothesis that childhood is associated with function status adulthood changes IQ mobility between midlife. <h3>Design, Setting, Participants</h3> A prospective cohort study based on population-representative 1972-1973 birth from New Zealand; Dunedin Multidisciplinary...
Air pollution is a worldwide environmental health issue. Increasingly, reports suggest that poor air quality may be associated with mental problems, but these studies often use global measures and rarely focus on early development when psychopathology commonly emerges. To address this, we combined high-resolution exposure estimates prospectively-collected phenotypic data to explore concurrent longitudinal associations between pollutants of major concern in urban areas problems childhood...
SignificanceConsiderable effort is expended to protect today's children from lead exposure, but there little evidence on the harms past exposures continue hold for yesterday's children, who are victims of what we term legacy exposures. We estimate that over 170 million Americans alive today were exposed high-lead levels in early childhood, several whom five-plus times current reference level. Our estimates allow future work plan health needs these and inform estimation true contributions...
Abstract Cognitive reserve is a hypothetical construct that has been used to inform models of cognitive aging and presumed be indicative life experiences may mitigate the effects brain pathology. The purpose this study was evaluate validity by examining both its convergent discriminant across three different samples participants using structural equation modeling. variables were found correlate highly with one another (thereby providing evidence validity), but demanding tests indicated that,...
<h3>Importance</h3> Millions of adults now entering middle age were exposed to high levels lead, a developmental neurotoxin, as children. Although childhood lead exposure has been linked disrupted behavioral development, the long-term consequences for adult mental and health have not fully characterized. <h3>Objective</h3> To examine whether is associated with greater psychopathology across life course difficult personality traits. <h3>Design, Setting, Participants</h3> This prospective...
<h3>Importance</h3> Air pollution exposure damages the brain, but its associations with development of psychopathology are not fully characterized. <h3>Objective</h3> To assess whether air in childhood and adolescence is associated greater at 18 years age. <h3>Design, Setting, Participants</h3> The Environmental-Risk Longitudinal Twin Study a population-based cohort study 2232 children born from January 1, 1994, to December 4, 1995, across England Wales followed up Pollution data generation...
<h3>Importance</h3> DNA methylation has been proposed as an epigenetic mechanism by which the childhood neighborhood environment may have implications for genome that compromise adult health. <h3>Objective</h3> To ascertain whether socioeconomic disadvantage is associated with differences in age 18 years. <h3>Design, Setting, and Participants</h3> This longitudinal cohort study analyzed data from Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative birth of...
<h3>Importance</h3> Childhood lead exposure has been linked to disrupted brain development, but long-term consequences for structural integrity are unknown. <h3>Objective</h3> To test the hypothesis that childhood is associated with magnetic resonance imaging (MRI) measurements of lower in midlife. <h3>Design, Setting, and Participants</h3> The Dunedin Study followed a population-representative 1972-1973 birth cohort New Zealand (N = 564 analytic sample) age 45 years (until April 2019)....
Childhood adversity has been previously associated with alterations in brain structure, but heterogeneous designs, methods, and measures have contributed to mixed results impeded progress mapping the biological embedding of childhood adversity. We sought identify long-term differences structural integrity adversity.Multiple regression was used test associations between prospectively ascertained during retrospectively reported adulthood magnetic resonance imaging midlife global regional...
Children who grow up in neighborhoods with more green vegetation show enhanced cognitive development specific domains over short timespans. However, it is unknown if neighborhood greenery per se uniquely predictive of children's overall measured across many years. The E-Risk Longitudinal Study, a nationally representative 1994-5 birth-cohort children Britain (n = 1658 urban and suburban-dwelling participants), was used to test whether residential predicts childhood adolescence. Greenery...
Abstract Children living near artisanal and small‐scale gold mining (ASGM) are at risk of exposure to mercury, a neurotoxicant. It is not certain whether such exposures harming development, as they occur in underresourced contexts entwined with other stressors, malnutrition enteric infection. This study sought investigate the association between hair‐mercury levels visual‐motor, cognitive, physical development among children ASGM Peruvian Amazon. Total were measured 164 ages 5–12 Madre de...
Knowledge about early risk factors for major depressive disorder (MDD) is critical to identify those who are at high risk. A multivariable model predict adolescents' individual of future MDD has recently been developed however its performance in a UK sample was far from perfect. Given the potential role air pollution aetiology depression, we investigate whether including childhood exposure as an additional predictor prediction improves identification adolescents greatest developing MDD. We...
Background Identification of at-risk individuals who would benefit from early intervention for Alzheimer's disease and related dementias (ADRD) is critical as new treatments are developed. Measures retinal health could offer accessible low-cost indication pre-morbid risk, but their association with ADRD risk unknown. Objective To determine whether midlife neuronal microvascular measures associated risk-index scores individual domains risk. Methods Data were the Dunedin Multidisciplinary...
Lead is a neurotoxin with well-documented effects on health. Research suggests that lead may be associated criminal behavior. This association difficult to disentangle from low socioeconomic status, factor in both exposure and offending.To test the hypothesis higher childhood blood level (BLL) greater risk of conviction, recidivism (repeat conviction), conviction for violent offenses, variety self-reported offending setting where BLL was not status.A total 553 individuals participated...