A5082457909- Neural dynamics and brain function
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Advanced Chemical Sensor Technologies
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Neural Networks and Applications
- Balance, Gait, and Falls Prevention
- Advanced MRI Techniques and Applications
Washington University in St. Louis
2020-2025
St. Louis Children's Hospital
2020-2021
Wide-field calcium imaging (WFCI) allows for monitoring of cortex-wide neural dynamics in mice. When applied to the study sleep, WFCI data are manually scored into sleep states wakefulness, non-REM (NREM) and REM by use adjunct EEG EMG recordings. However, this process is time-consuming often suffers from low inter- intra-rater reliability invasiveness. Therefore, an automated state classification method that operates on alone needed.A hybrid, two-step proposed. In first step,...
Abstract Aim To determine the movement features governing expert assessment of gait dystonia severity in individuals with cerebral palsy (CP). Method In this prospective cohort study, three disorder neurologists graded lower extremity videos CP using a 10‐point Likert‐like scale. Using conventional content analysis, we determined experts cited when grading severity. Then, open‐source pose estimation techniques, variable analogs these expert‐cited correlating their assessments Results Experts...
INTRODUCTION: Gait analysis and severity grading in spine surgery are mostly subjective. Objective measurement of gait by spatiotemporal parameters using 3D Motion Capture technology is a newer emerging technique, yet to be validated for use patients. Correlating with standard clinical can the initial step set tone validation assessing application surgery. METHODS: A total 281 videos walking tandem 26 Cervical Myelopathy patients presenting 3 Barnes Jewish Hospital locations were recorded at...
Neural activity in the delta range (1.0-4.5 Hz) during non-rapid eye movement (NREM) sleep is crucial for brain plasticity and overall health. Recent research has shown that changes NREM can occur locally, vary across different regions. Ischemic stroke results focal injury long-term disability. While disruption acute phase of known to hinder recovery, relationship between region-specific functional recovery remains poorly understood. To investigate these localized with high spatial...
Normal aging is associated with a variety of neurologic changes including declines in cognition, memory, and motor activity. These correlate neuronal synaptic structure function. Degradation brain network activity connectivity represents likely mediator age-related functional deterioration resulting from these changes. Human studies have demonstrated both general decreases spontaneous cortical disruption networks aging. Current techniques used to study cerebral are hampered either by limited...
Background Early spasticity and dystonia identification in cerebral palsy is critical for guiding diagnostic workup prompting targeted treatment early when it most efficacious. However, differentiating from difficult young children with palsy. Methods We sought to determine underidentification rates at high risk (following neonatal hypoxic-ischemic encephalopathy) by assessing how often child neurologists identified hypertonia alone versus specifying the type as and/or age 5 years. Results...
Neural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral physiological measurements. We propose that this covariation reflects part the dynamics of a unified, multidimensional arousal-related process regulates brain-wide physiology on timescale seconds. By framing interpretation within dynamical systems theory, we arrive at surprising prediction: single, scalar measurement arousal (e.g., pupil diameter) should suffice to reconstruct...
Aim To determine the features cited by motor phenotyping experts when identifying dystonia in people with cerebral palsy (CP). Method Dystonia identification CP, particularly comorbid spasticity, can be difficult. The diagnostic criterion standard remains subjective visual expert consensus. For this qualitative study, we conducted an inductive thematic analysis of consensus‐building discussions between three pediatric movement disorder physicians as they identified presence or absence gait...
Wide-field calcium imaging (WFCI) with genetically encoded indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study sleep, WFCI data are manually scored into sleep states wakefulness, non-REM (NREM) and REM by use adjunct EEG EMG recordings. However, this process is time-consuming, invasive often suffers from low inter- intra-rater reliability. Therefore, an automated state classification method that operates on desired.
Deep learning methods have been developed to classify sleep states of mouse electroencephalogram (EEG) and electromyogram (EMG) recordings with accuracy reported as high 97%. However, when applied independent datasets, a variety experimental recording conditions, state classification often drops due distributional shift. Mixture z-scoring, pre-processing standardization EEG/EMG signals, has suggested account for these variations. This study sought validate mixture z-scoring in combination...
Background: Wide-field calcium imaging (WFCI) with genetically encoded indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study sleep, WFCI data are manually scored into sleep states wakefulness, non-REM (NREM) and REM by use adjunct EEG EMG recordings. However, this process is time-consuming, invasive often suffers from low inter- intra-rater reliability. Therefore, an automated state classification method that operates on desired. New Method:...
Wide-field calcium imaging (WFCI) that records neural dynamics allows for identification of functional brain networks (FBNs) in mice express genetically encoded indicators. Estimating FBNs from WFCI data is commonly achieved by use seed-based correlation (SBC) analysis and independent component (ICA). These two methods are conceptually distinct each possesses limitations. Recent success unsupervised representation learning neuroimage motivates the investigation such to identify FBNs. In this...
Stroke is the leading cause of chronic disability in United States. How stroke size affects post-stroke repair and recovery poorly understood. We aim to investigate effects on early patterns determine how changes neuronal circuits networks predict functional outcomes after stroke. used wide-field optical imaging, photothrombosis, cylinder-rearing assay examine circuit network activity context Larger strokes ablating S1FP caused diffuse widespread forepaw stimulus-evoked cortical activation,...
Abstract Background Dystonia diagnosis is subjective and often difficult, particularly when co-morbid with spasticity as occurs in cerebral palsy. Objective To develop an objective clinical screening method for dystonia Methods We analyzed 30 gait videos (640×360 pixel resolution, frames/second) of subjects spastic palsy acquired during routine clinic visits. was identified by consensus three movement disorders specialists (15 15 without dystonia). Limb position calculated using deep neural...
Abstract Normal aging is associated with a variety of neurologic changes including declines in cognition, memory, and motor activity. These correlate neuronal synaptic structure function. Degradation brain network activity connectivity represents likely mediator age-related functional deterioration resulting from these changes. Human studies have demonstrated both general decreases spontaneous cortical disruption networks aging. Current techniques used to study cerebral are hampered either...
Abstract Aim To determine the specific movement features in children with cerebral palsy (CP) that prompt expert identification of dystonia Methods Dystonia CP, particularly when co-morbid spasticity, can be difficult. For this retrospective case-control study, we conducted a qualitative thematic analysis consensus-building discussions between three pediatric disorders physicians as they attempted to identify presence or absence gait videos 40 subjects spastic CP and periventricular...
Abstract Aim To determine an objective and clinically-feasible method to predict dystonia in cerebral palsy (CP) using magnetic resonance imaging (MRI) following neonatal hypoxic-ischemic encephalopathy (HIE). Methods In this retrospective case-control study, we examined brain MRIs neonates at age 4–5 days who underwent therapeutic hypothermia for HIE a single tertiary care center. The lower average apparent diffusion coefficient (ADC) values between the left right striatum thalamus were...