A5077265749- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Chromatin Remodeling and Cancer
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Renal cell carcinoma treatment
- Veterinary Oncology Research
- Lymphadenopathy Diagnosis and Analysis
- Musculoskeletal Disorders and Rehabilitation
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Single-cell and spatial transcriptomics
- HER2/EGFR in Cancer Research
- Lower Extremity Biomechanics and Pathologies
- Veterinary Equine Medical Research
- Acute Ischemic Stroke Management
- Diphtheria, Corynebacterium, and Tetanus
- Global Health Workforce Issues
- Immunotherapy and Immune Responses
Virginia Commonwealth University
2024-2025
University Health System
2024
University of Virginia Health System
2020-2023
University of Virginia
2020-2022
University of Arizona
2020
University of Pennsylvania Health System
2019
Hospital of the University of Pennsylvania
2016-2019
University of Liverpool
1992-2017
St Mark's Hospital
1992
Mesonephric-like endometrial carcinoma is a rare but frequently misclassified and aggressive malignancy. KRAS mutations, limited estrogen receptor (ER) expression, TTF-1, GATA3, luminal CD10 expression are described in these tumors, an immunohistochemistry-based screening approach has not been studied. We assessed 300 carcinomas/carcinosarcomas to ascertain the specificity of TTF-1/GATA3/luminal with or without ER staining for this diagnosis. Next-generation sequencing morphologic review...
Uterine carcinosarcoma (UCS) is an aggressive malignancy with few treatment options. A recent clinical trial has shown increase in progression-free survival patients human epidermal growth factor receptor 2 (HER2)-positive serous endometrial carcinomas treated anti–HER2-targeted therapies. Few studies have evaluated HER2 expression/amplification UCS. Similar to carcinoma, the majority of UCS TP53 mutations and a epithelial component, suggesting that may show similar rates positivity...
Background Higher levels of tumor-infiltrating lymphocytes (TILs) in breast cancers are associated with increased likelihood pathologic complete response (pCR) to chemotherapy. DNA methyltransferase inhibitors (DNMTi) can augment immune responses cancers, decreasing myeloid-derived suppressor cells (MDSCs) and increasing T lymphocyte responsiveness. We have shown that the DNMTi decitabine augments effectiveness immunotherapy using murine triple-negative cancer (TNBC) models. The primary...
Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is recommended in endometrial carcinomas as a screening test Lynch syndrome, and deficiency (MMRd) reported ∼30% of cases. However, few studies have evaluated the rate MMR loss uterine carcinosarcomas. A 5-year retrospective database search carcinosarcomas was performed at 3 academic institutions. The histologic diagnoses, type carcinoma present, IHC interpretations were confirmed by gynecologic pathologist. One hundred three...
Endometrial somatically derived yolk sac tumors are characterized by morphology with AFP, SALL-4, and/or Glypican-3 immunoexpression. Yolk marker expression, however, is not limited to overt histology. Three hundred consecutive endometrial malignancies were assessed for immunomarkers of differentiation. Of these, 9% expressed ≥1 marker, including 29% high-grade tumors. Only 3 (1%) met morphologic criteria differentiation; these originally diagnosed as serous, NOS, and dedifferentiated...
Abstract Introduction The extracellular matrix (ECM) provides structural support for neuronal, glial, and vascular components of the brain, regulates intercellular signaling required cellular morphogenesis, differentiation homeostasis. We hypothesize that pathophysiology diffuse brain injury impacts ECM in a multi‐dimensional way across regions over time, which could facilitate damage repair processes. Methods Experimental TBI was induced male Sprague‐Dawley rats (325–375 g) by midline fluid...
Since the establishment of 4 molecular subgroups endometrial carcinoma (EC), there has been significant interest in understanding classification context histologic features and diagnoses. ECs with undifferentiated, spindle, and/or sarcomatous components represent a diagnostically challenging subset tumors overlapping clinical features. We examined clinicopathologic, morphologic, immunohistochemical, these identified our institutions' pathology databases using immunohistochemistry targeted...
Tumor cell expression of major histocompatibility complex (MHC) class I is required for antigen presentation and adaptive immune recognition. Absent or diminished MHC thought to contribute immunotherapeutic resistance in some epithelial tumors but has not been previously studied cervical vulvar carcinoma. Given that anti–programmed death 1 (PD-1) checkpoint inhibition deployed programmed ligand (PD-L1)-positive recurrent metastatic squamous carcinomas, identifying with loss clinical interest...
Different cellular compartments within a tissue present distinct cancer-initiating capacities. Current approaches to dissect such heterogeneity require cell-type-specific genetic tools based on well-understood lineage hierarchy, which are lacking for many tissues. Here, we circumvented this hurdle and revealed the dichotomous capacity of fallopian tube Pax8+ cells in initiating ovarian cancer, utilizing mouse system that stochastically generates rare GFP-labeled mutant cells. Through clonal...
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive type of non–small cell lung carcinoma (NSCLC) presenting in adults the fourth to fifth decade. The prognosis poor after surgical resection, therapeutic options are often limited. ROS1 proto-oncogene receptor tyrosine kinase that has been identified some types NSCLC. We report case 36-year-old woman with CBPB, which was subsequently found have rearrangement. This first reported ROS1-rearranged CBPB. finding implications as...
Small cell carcinoma of the ovary, hypercalcemic type is a rare, aggressive, and typically fatal ovarian cancer that primarily affects young women less than 40 years age. It caused by pathogenic variant in SMARCA4 gene, with nearly half patients found to have germline variants remainder demonstrating somatic variants. This case report discusses an illustrative explores existing data potential recommendations optimize timing genetic testing family members, given presence familial variant.
Uterine carcinosarcomas have few adjuvant treatment options. Programmed cell death ligand-1 (PD-L1) expression in these tumors may predict response to checkpoint inhibitor therapies. An increase PD-L1 has been shown endometrial carcinomas with mismatch repair (MMR) deficiencies; however, studies evaluated uterine carcinosarcomas. We examined 41 cases of carcinosarcoma using combined positive scores (CPS) and tumor proportion (TPS), correlated MMR status, p53 expression, epithelial histotype....
Context.— Pathology training programs generally prepare graduates well for the workforce, but there may be other aspects to navigating a job that make transition from being trainee practicing pathologist challenging. Objective.— To identify perceived challenges of independent practice early career pathologists and assess how these impressions evolve throughout their first year. Design.— A survey was distributed 12 anatomic pathology fellows 4 institutions near end final year, 6 months 1 year...
Abstract Objectives Pathology and laboratory medicine (PALM) services in low- middle-income countries are essential to combat the increasing prevalence of cancer addition providing documentation types trends for future allocation public health resources. There many ways PALM as a whole can engage on global front. This study summarizes efforts results educational clinical elective pathology residents Quetzaltenango, Guatemala. Methods led implemented project, working alongside an in-country...
Context.— The use of immunohistochemical stains in breast and gynecologic pathology has become increasingly complex, with various diagnostic, prognostic, predictive applications. Objective.— To provide an update review used the practice pathology. Established new entities are reviewed, descriptions histomorphology staining patterns discussion interpretive pitfalls. Data Sources.— were obtained from English-language literature firsthand experience authors Conclusions.— Many benefit evaluation...