A5002664053- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Head and Neck Cancer Studies
- Ear and Head Tumors
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Head and Neck Surgical Oncology
- Hereditary Neurological Disorders
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Neurological diseases and metabolism
- Neurological disorders and treatments
- Ferroptosis and cancer prognosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Venous Thromboembolism Diagnosis and Management
Tongji University
2018-2024
Tongji Hospital
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Guangdong Pharmaceutical University
2023-2024
Molina Center for Energy and the Environment
2022
University of Shanghai for Science and Technology
2021-2022
Shanghai University of Medicine and Health Sciences
2022
Huazhong University of Science and Technology
2016-2021
Academy of Medical Sciences
2019-2021
Ministry of Education of the People's Republic of China
2020
Autophagy plays an important role in Alzheimer's disease (AD). It has been reported that autophagic flux is altered patients with AD, and application of the autophagy enhancer rapamycin may alleviate cognitive impairment amyloid-β (Aβ) neuropathology transgenic animal model AD. Since also immune suppressor, there a concern long-term use bring severe unwanted side effects. The aim this study to test if carbamazepine (CBZ), anti-epileptic drug potent enhancement effect, anti-AD effects...
Mutations in the proline-rich transmembrane protein 2 (PRRT2) are associated with paroxysmal kinesigenic dyskinesia (PKD) and several other neurological diseases, but PRRT2 function pathogenic mechanisms remain largely obscure. Here we show that is a presynaptic interacts components of SNARE complex downregulates its formation. Loss-of-function mutant mice showed PKD-like phenotypes triggered by generalized seizures, hyperthermia, or optogenetic stimulation cerebellum. Mutant specific...
To analyze the impact of global population aging on cancer epidemiology, with a focus incidence and mortality rates among individuals aged 60 years above.
The glycogen synthase kinase-3β (GSK3β) pathway plays a central role in Alzheimer's disease (AD) and its deregulation accounts for many of the pathological hallmarks AD. Lithium, which modulates GSK3β activity, has been shown to reduce amyloid production tau phosphorylation pre-pathological AD mouse models. In this study, we investigated effects chronic LiCl treatment aged double transgenic mice (AβPP Swe /PS1 A246E ). We found that lithium decreased γ-cleavage amyloid-β protein precursor,...
Abstract Inflammation plays a crucial role in the occurrence and development of renal fibrosis, which ultimately results end-stage disease (ESRD). There is new focus on lymphangiogenesis field inflammation. Recent studies have revealed association between but source lymphatic endothelial cells (LECs) not clear. It has also been reported that macrophages are involved through direct indirect mechanisms other tissues. We hypothesized there was close relationship progenitor fibrosis. In this...
Breast cancer has become the most prevalent malignancy worldwide; however, therapeutic efficacy is far from satisfactory. To alleviate burden of this disease, it imperative to discover novel mechanisms and treatment strategies. Protein phosphatase 2 A (PP2A) comprises a family mammalian serine/threonine phosphatases that regulate many cellular processes. PP2A dysregulated in several human diseases, including oncological pathologies, plays pivotal role initiation progression tumours. The as...
Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. However, little known about the molecular landscape and efficacy of therapy in HER2-mutated metastatic cancer. We analysed HER2 mutation features 1184 invasive In addition, a single-arm, prospective, phase-II study (NCT03412383) pyrotinib was conducted patient...
Purpose: Low-dose metronomic chemotherapy can achieve disease control with reduced toxicity compared to conventional in maximum tolerated dose. Characterizing the gut microbiota of cancer patients under different dosage regimens may describe a new role associated drug efficacy. Therefore, we evaluated composition and function microbiome capecitabine dosage. Methods: The fecal samples HER2-negative metastatic breast treated as maintenance were collected analyzed by 16S ribosome RNA gene...
Background Although the relationship between a history of kidney stones and chronic disease (CKD) has been explored in many studies, it is still far from being well understood. Thus, we conducted meta-analysis studies comparing rates CKD patients with stones. Methods PubMed, EMBASE, reference lists relevant articles were searched to identify observational related topic. A random-effects model was used combine study-specific risk estimates. We potential heterogeneity by subgroup analyses...
•The concordance between HER2 amplification in ctDNA and tumor tissues was 86.5%.•The positive negative predictive value surpassed previous studies.•HER2 copy numbers may predict the prognosis of anti-HER2 therapy.•HER2 response breast cancer.•The study various-stage patients be closer to real-world clinical practice. BackgroundHuman epidermal growth factor receptor 2(HER2) status is a crucial for prognostic assessment targeted therapy selection, which influenced by intratumor heterogeneity...
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with few therapeutic options available currently. Hemp seed oil extracted from the seeds of hemp (Cannabis sativa L.) has significant nutritional and biological properties due to unique composition polyunsaturated fatty acids various antioxidant compounds. However, little known about beneficial effects molecular mechanisms on NASH. Here, hepatoprotective methionine-choline-deficient (MCD) diet-induced NASH in C57BL/6 mice were...
Everolimus, an inhibitor of mammalian target rapamycin (mTOR), has been shown to increase the efficacy endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because cancer is a highly heterogeneous disease, responses different patients everolimus may vary. Therefore, we performed this study better select who will benefit most from or be resistant everolimus. Patients with HR-positive were treated at Cancer Hospital, Chinese Academy Medical Sciences February...
Abstract Purpose We used targeted capture sequencing to analyze TP53 ‐mutated circulating tumor DNA (ctDNA) in metastatic breast cancer patients and determine whether mutation has predictive value for anti‐human epidermal growth factor receptor 2 (HER2) treatment HER2 amplification‐positive (HER2+) mutation‐positive, amplification‐negative (HER2−/mut) patients. Patients Methods features were analyzed the Geneplus cohort (n = 1184). The MSK‐BREAST was explore of predicting anti‐HER‐2 antibody...
It is particularly important to provide precise therapies and understand tumor heterogeneity based on the molecular typing of mutational landscape. However, landscape somatic mutations in different subtypes advanced breast cancer (ABC) largely unknown. We applied target-region capture deep sequencing determine frequency spectrum common cancer-related gene circulating DNA (ctDNA) among ABC analyze their association with clinical features. In this retrospective study 100 female patients, 96...
Charcot-Marie-Tooth disease type 4D (CMT4D) is an autosomal-recessive demyelinating form of CMT characterized by a severe distal motor and sensory neuropathy. NDRG1 the causative gene for CMT4D. To date, only four mutations in -c.442C>T (p.Arg148*), c.739delC (p.His247Thrfs*74), c.538-1G>A, duplication exons 6-8-have been described CMT4D patients. Here, using targeted next-generation sequencing examination, we identified first time two homozygous missense variants NDRG1, c.437T>C...
Abstract Background The current standard of care for advanced human epidermal growth factor receptor 2 (HER2)‐positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first‐line therapy. However, with the development newer treatment regimens, there a lack evidence regarding which optimal strategy. aim this network meta‐analysis was to evaluate efficacy safety regimens HER2‐positive by indirect comparisons. Methods A systematic review Bayesian were conducted. PubMed, EMBASE,...
Abstract Background An increasing number of cancer patients die cardiovascular diseases. The cardiotoxicity chemotherapy is particularly important in triple‐negative breast (TNBC) with limited therapeutic options. Cardiac autophagy an mechanism cardiotoxicity. This research was aimed to investigate the TNBC, screen susceptible population, and determine relationship between autophagy‐related polymorphisms. Methods From a total 2450 stage I‐III TNBC patients, 147 met inclusion criteria finally...
BackgroundWe performed a retrospective study on the efficacy and safety of sirolimus (an mTOR inhibitor) in hormone receptor (HR)-positive advanced breast cancer searched for biomarkers to predict its efficacy.MethodsAll patients with HR-positive metastatic treated plus endocrine therapy between December 2017 July 2018 at Cancer Hospital, Chinese Academy Medical Sciences were consecutively retrospectively reviewed. Mutations circulating tumour DNA (ctDNA) assayed 1021 tumour-related genes...