A5022416840- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer-related cognitive impairment studies
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- BRCA gene mutations in cancer
- Breast Implant and Reconstruction
- Tumors and Oncological Cases
- Telomeres, Telomerase, and Senescence
- Global Cancer Incidence and Screening
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
National Clinical Research
2024
Abstract The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests biomechanical force are critical progression. In this study, we aimed to explore the influence of ECM-derived on breast cancer status. Experiments were conducted using 3D collagen, fibrinogen, and Matrigel matrices investigate role mechanical development. Integrin-cytoskeleton-AIRE DDR-STAT examined RNA sequencing western blotting. Data from 1358...
Triple negative breast cancer (TNBC), the most aggressive subtype of cancer, is characterized by a high incidence brain metastasis (BrM) and poor prognosis. As lethal form BrM remains major clinical challenge due to its rising lack effective treatment strategies. Recent evidence suggested potential role lipid metabolic reprogramming in (BCBrM), but underlying mechanisms are far from being fully elucidated.Through analysis BCBrM transcriptome data mice patients, immunohistochemical validation...
Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. However, little known about the molecular landscape and efficacy of therapy in HER2-mutated metastatic cancer. We analysed HER2 mutation features 1184 invasive In addition, a single-arm, prospective, phase-II study (NCT03412383) pyrotinib was conducted patient...
Importance Understanding the detailed symptom spectrum of chemotherapy-induced peripheral neuropathy (CIPN) could facilitate shared decision-making and promote early intervention. Objective To compare patient-reported CIPN associated with nab-paclitaxel, paclitaxel, docetaxel treatments among patients breast cancer. Design, Setting, Participants This prospective cohort study was conducted at 9 medical centers across China from 2019 to 2021. included hospitalized women diagnosed invasive...
Abstract Purpose We used targeted capture sequencing to analyze TP53 ‐mutated circulating tumor DNA (ctDNA) in metastatic breast cancer patients and determine whether mutation has predictive value for anti‐human epidermal growth factor receptor 2 (HER2) treatment HER2 amplification‐positive (HER2+) mutation‐positive, amplification‐negative (HER2−/mut) patients. Patients Methods features were analyzed the Geneplus cohort (n = 1184). The MSK‐BREAST was explore of predicting anti‐HER‐2 antibody...
BackgroundWe performed a retrospective study on the efficacy and safety of sirolimus (an mTOR inhibitor) in hormone receptor (HR)-positive advanced breast cancer searched for biomarkers to predict its efficacy.MethodsAll patients with HR-positive metastatic treated plus endocrine therapy between December 2017 July 2018 at Cancer Hospital, Chinese Academy Medical Sciences were consecutively retrospectively reviewed. Mutations circulating tumour DNA (ctDNA) assayed 1021 tumour-related genes...
As a critical immune checkpoint molecule, PD-L1 is expressed at significantly higher levels in multiple neoplastic tissues compared to normal ones. PD-L1/PD-1 axis target for tumor immunotherapy, blocking the recognized and has achieved unprecedented success clinical applications. However, efficacy of therapies targeting PD-1/PD-L1 pathway remains limited, emphasizing need mechanistic elucidation expression. In this study, we found that RNF125 interacted with regulated protein...
Breast cancer (BRCA) is the most common malignant tumor that seriously threatens health of women worldwide. Senescence has been suggested as a pivotal player in onset and progression tumors well process treatment resistance. However, role senescence BRCA remains unelucidated. The clinical transcriptomic data 2994 patients with were obtained from Cancer Genome Atlas METABRIC databases. Consensus clustering revealed senescence-associated subtypes patients. Functional enrichment analysis...
Background: Two ongoing prospective randomized trials are evaluating whether omitting axillary lymph node dissection (alnd) in patients with breast cancer (bca) and sentinel (sln) macrometastases undergoing mastectomy is safe. Determining predictive risk factors for non-sln metastases developing a model to predict the probability of those having also important. Methods: This retrospective study enrolled 396 bca 1–2 slns who underwent alnd between January 2012 December 2016. Factors...
SURF4 has been suggested as an oncogene in cancer. However, the role of breast cancer not demonstrated yet. The data were obtained from TCGA database and 1104 patients analyzed using bioinformatics analysis. is significantly (P < 0.001) highly expressed tumor. High expression was observed T4, infiltrating ductal carcinoma, ER negative, PR HER2 positive, female, without lymph node metastasis, overexpression type, deceased patients. As for characteristics correlated with high SURF4, gender,...
Lung adenocarcinoma (LUAD) patients with elevated breast cancer susceptibility gene 1 (BRCA1) expression had markedly worse overall survival and progression-free compared to those reduced BRCA1 levels. In contrast, did not correlate outcomes in squamous cell carcinoma patients. The overexpression of was an independent risk factor for LUAD indicative immune-suppressive tumor microenvironment. Non-small-cell lung (NSCLC) is the primary histopathological subtype accounts around 82% all...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of neoplasms with a higher risk recurrence and metastasis than non-TNBC. Nevertheless, factors responsible for differences in malignant behavior between TNBC non-TNBC are not fully explored. Proline rich 15 (PRR15) protein involved progression several tumor types, but its mechanisms still controversial. Therefore, this study aimed to investigate biological role clinical applications PRR15 on TNBC. gene was...
The mechanism of acquired gene mutation plays a major role in resistance to endocrine therapy hormone receptor (HR)-positive advanced breast cancer. Circulating tumor DNA (ctDNA) has been allowed for the assessment genomic profiles patients with We performed this study search molecular markers efficacy and explore clinical value ctDNA guide precise HR-positive/human epidermal growth factor receptor-2 (HER-2)-negative metastatic cancer patients.In open-label, multicohort, prospective study,...
Occult breast cancer (OBC) is a special type of an unknown primary origin. Early stage OBC treated as II−III cancer. Currently, there are no models for predicting the survival outcomes. Hence, we aimed to evaluate role positive lymph node ratio (PLNR) in and further establish validate prognostic nomogram. Patients with T0N+M0 were enrolled from Surveillance, Epidemiology, End Results database. Univariate multivariate Cox analyses used effects factors on breast-cancer-specific (BCSS),...
To the Editor: Tumor immune microenvironment plays a key role in breast cancer development and progression, which determines long-term survival of patients. Recent data have revealed that application immunotherapy has some limitations, including generating weak responses due to inadequate delivery immunostimulants cells.[1] Thus, current clinical efforts are primarily focused on developing immune-based chemotherapy can convert non-responders responders.[2] Immunogenic cell death (ICD) is...
Abstract Background: Combining Immune checkpoint blockade (ICB) with chemotherapy may significantly improve efficacy in patients breast cancer. Metronomic is based on more frequent and low-dose drug administrations compared conventional chemotherapy. Some clinical studies small samples have tried the combination of metronomic ICB advanced tumors. However, whether suitable for than still unclear. Thus, we performed first trial, to our knowledge, combined PD-1 comparing ICB. Methods: This...
Abstract Background: The question of how chemotherapeutic drugs affect the efficacy PD-1/PD-L1 antibodies in patients with breast cancer is still pending. In a previously single-cell sequencing study, we have demonstrated that paclitaxel reduces level CXCL13+ T cells and other immune critical for atezolizumab to work, leading inferior triple negative (TNBC). How affects these important remains obscure. Recently, plasma metabolomic proteomics analysis shown patients’ systemic metabolic...
Breast cancer has both aggressive clinicopathological characteristics and a poor prognosis in young females. However, limited information is available for breast Chinese females aged ≤25 years. Therefore, we aimed to explore prognostic factors invasive disease-free (iDFS) overall survival (OS) among patients years.We retrospectively analyzed data from 174 years with treated the Cancer Hospital of Academy Medical Sciences January 1, 1999, December 31, 2018. Univariate multivariate Cox...
BackgroundTaxane-induced peripheral neuropathy (TIPN) is a debilitating adverse effect of cancer treatments with taxanes which may require reduction or discontinuation chemotherapy and affect clinical survival outcomes. A number factors have contributed to the increasing prevalence TIPN. Nonetheless, limited knowledge exists potential prechemotherapy blood-based biochemical associated TIPN development.MethodsWe recruited breast patients at seven institutions in China. Participants aged 18...
Abstract Background: Although cardiotoxicity has been widely concerned, the study of early-onset is insufficient and it difficult to explain occurrence only by clinical factors in patients with low cumulative dose chemotherapy. The purpose this was investigate adjuvant chemotherapy -related cardiac events breast cancer patients, find out genetic risk related . Methods: A total 388 recruited completed routine blood, liver kidney function, D-dimer, TnT, NT-proBNP (or BNP), ECG UCG tests before...
Because of the rarity occult breast cancer (OBC) and limited experience in OBC treatment, optimal treatment strategy is unknown. This study aimed to compare efficacy axillary lymph node dissection (ALND) plus radiotherapy with that mastectomy ALND patients OBC. Relevant clinical data between January 2004 December 2015 were retrospectively collected from Surveillance, Epidemiology, End Results database. The characteristics prognoses who underwent or compared before after propensity score...