A5101752732- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cardiac and Coronary Surgery Techniques
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiac Valve Diseases and Treatments
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Cellular Mechanics and Interactions
- TGF-β signaling in diseases
- Cancer, Lipids, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Genomic variations and chromosomal abnormalities
- Glioma Diagnosis and Treatment
- Cerebrovascular and genetic disorders
- Pancreatic and Hepatic Oncology Research
- Transplantation: Methods and Outcomes
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- Heart Failure Treatment and Management
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
Second Hospital of Shandong University
2018-2024
Sichuan University
2021-2023
West China Hospital of Sichuan University
2022-2023
Shandong First Medical University
2023
University of Shanghai for Science and Technology
2023
Affiliated Hospital of Taishan Medical University
2023
Aerospace Center Hospital
2016
Abstract The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests biomechanical force are critical progression. In this study, we aimed to explore the influence of ECM-derived on breast cancer status. Experiments were conducted using 3D collagen, fibrinogen, and Matrigel matrices investigate role mechanical development. Integrin-cytoskeleton-AIRE DDR-STAT examined RNA sequencing western blotting. Data from 1358...
To investigate the clinical significance of minimally invasive direct coronary artery bypass (MIDCAB). Three hundred patients admitted to Second Hospital Shandong University from March 2006 February 2010 were retrospectively analyzed and received off-pump operation under general anesthesia. Depending on surgical methods, divided into MIDCAB group (n = 90) median sternotomy (OPCAB) group, named as OPCAB 210). Preoperative data, perioperative mid-term follow-up at 7 years after compared...
In observational and experimental studies, diabetes has been reported as a protective factor for aortic dissection. 3-Hydroxybutyrate, key constituent of ketone bodies, found to favor improvements in cardiovascular disease. However, whether the effect on dissection is mediated by 3-hydroxybutyrate unclear. We aimed investigate causal effects risk mediating role them through two-step Mendelian randomization.
This study was designed to investigate the long non‑coding RNA (lncRNA)‑metastasis associated lung adenocarcinoma transcript 1 (MALAT1) expression in patients with coronary atherosclerosis and its predictive value for in‑stent restenosis. Ninety‑five heart disease who came our hospital treatment underwent stent implantation were selected as a research group (RG), 95 volunteers undergoing physical examination did not suffer from during same period control (CG). MALAT1 of subjects both groups...
In this retrospective study, we presented the results of Castor single-branched stent-graft in a small series patients with acute type B aortic syndrome and aberrant right subclavian artery (ARSA).Between January 2019 November 2019, 5 were diagnosed ARSA (4 intramural hematoma ARSA, 1 patient dissection ARSA). All underwent thoracic endovascular repair (TEVAR) using stent-graft. In-hospital 3-month outcomes collected.The mean operative time was 116 ± 20.43 minutes (range 90-145). TEVAR...
Modeling of genomic profiles from the Cancer Genome Atlas (TCGA) by using recently developed mathematical frameworks has associated a genome-wide pattern DNA copy-number alterations with shorter, roughly one-year, median survival time in glioblastoma (GBM) patients. Here, to experimentally test this relationship, we whole-genome sequenced tumor samples We show that patients represent U.S. adult GBM population terms most normal and disease phenotypes. Intratumor heterogeneity affects ≈11%...
This study aimed at observing the expression of lncRNA‐ANRIL (ANRIL) before and after treatment its predictive value for short‐term survival in patients with coronary heart disease (CHD). Altogether, 112 CHD admitted to hospital were enrolled as a group (SG), which was divided into pretreatment (preSG) posttreatment (postSG). Further 72 healthy people undergoing physical examinations during same period control (CG). Peripheral blood collected from subjects three groups, detect level serum...
Background Increasing evidence has emerged to reveal the correlation between genomic instability and long non-coding RNAs (lncRNAs). The instability-derived lncRNA landscape of prostate cancer (PCa) its critical clinical implications remain be understood. Methods Patients diagnosed with PCa were recruited from Cancer Genome Atlas (TCGA) program. Genomic instability-associated lncRNAs identified by a mutator hypothesis-originated calculative approach. A signature (GILncSig) was derived...
The aim of the present study was to evaluate protective effects and safety aspects recombinant human brain natriuretic peptide (rhBNP) on cardiac functions patients undergoing open-heart surgery during perioperative period. In total, 150 open heart in Second Hospital Shandong Universty from August 2015 July 2016 were randomly divided into control group observation each with 75 cases. Patients treated by routine rehabilitation while both rhBNP. All observations made before operation, after...
Background: Long non-coding RNAs (lncRNAs) have been documented to be associated with genomic instability. Genomic instability-associated lncRNAs of prostate cancer (PCa) and their critical clinical implications remain understood.Method: A signature ( GILncSig ) was derived by classify PCa patients into high-risk low-risk group. The association biochemical recurrence (BCR) is validated across three different datasets. mutation burden gene expression were compared between two risk...