A5068326949- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Hematological disorders and diagnostics
- Renal Transplantation Outcomes and Treatments
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Studies on Chitinases and Chitosanases
- Eosinophilic Disorders and Syndromes
- Oral health in cancer treatment
- Mesenchymal stem cell research
- Corneal Surgery and Treatments
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
University Hospital Centre Zagreb
2015-2024
University of Zagreb
2007-2024
Hôpital Robert-Debré
2020
University of Rome Tor Vergata
2020
École des Hautes Études en Santé Publique
2020
Université Paris-Saclay
2020
Taipei Veterans General Hospital
2019
Sidney Kimmel Comprehensive Cancer Center
2004-2017
Johns Hopkins University
2004-2017
Landeskrankenhaus Feldkirch
2011
A rise in infections with multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is a significant contributor to increased morbidity and mortality of patients hematologic malignancies. The aim this study was determine the efficacy safety colistin (colistimethate sodium) treatment serious caused by MDR-PA these patients.A matched pair analysis renal function, toxicities, outcome 26 receiving control subjects done. All had clinical signs sepsis; P. isolated from blood 69% group 84% group....
Abstract Mouse models of minor histocompatibility Ag-mismatched bone marrow transplantation were used to study donor dendritic cell (DC) reconstitution after conditioning, variables influencing the persistence residual host DCs in different compartments, their phenotype, and role governing lymphocyte infusion (DLI)-mediated alloresponses. Reconstitution all splenic DC subsets occurred rapidly before T reconstitution. However, contrast MHC-mismatched chimeras, host-derived persisted cutaneous...
AbstractBusulfan (Bu)/cyclophosphamide (Cy) is a standard conditioning platform for allogeneic transplantation. We developed strategy separating the Cy into two pre/post-transplantation doses (PTCy), providing myeloablative and single-agent graft-versus-host disease (GVHD) prophylaxis. investigated impact of Bu route on treatment-related toxicity 131 consecutive adult patients. Busulfan was administered in four daily divided either orally (n = 72) or intravenously 59) with pharmacokinetics...
AimTo investigate the ability of two standard quality life (QOL) questionnaires – The Short Form (36-item) Health Survey (SF-36) and European Organisation for Research Treatment Cancer Quality Life Questionnaire-Core 30 (EORTC QLQ C30) to evaluate QOL in patients with chronic graft-vs-host disease (cGVHD) graded according National Institutes (NIH) consensus criteria.MethodsIn this cross-sectional study, was assessed who underwent allogeneic stem cell transplantation (allo-SCT) at University...
Disease- and treatment-mediated immunodeficiency might render SARS-CoV-2 vaccines less effective in patients with hematologic diseases. We performed a prospective non-interventional study to evaluate humoral response after one two doses of mRNA-1273, BNT162b2, or ChAdOx1 nCoV-19 vaccine 118 different malignant non-malignant diseases from three Croatian treatment centers. An electrochemiluminescent assay was used measure total anti-SARS-CoV-2 S-RBD antibody titers. After dose, 20/66 (33%)...
Objectives: Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), are characterized by clonal myeloproliferation a strong inflammatory atmosphere. YKL-40, expressed in granulocytes, macrophages, megakaryocytes malignant cells, is an acute phase reactant with important role tissue remodeling atherosclerotic inflammation. The aim of this study was to investigate serum YKL-40 levels MPNs assess its...
Background. There are limited data examining the effects of pharmacological immunosuppression on in vivo fate donor lymphocyte infusions (DLI)-derived T cells, their function, and antitumor efficacy. Methods. We addressed this question a murine model which DLI is given to stable mixed chimeras resulting lymphohematopoietic graft-versus-host (LH-GVH) response. In model, LH-GVH potency can be directly measured as kinetics conversion full chimerism correlated with associated...
Escalated BEACOPP (eBEACOPP) is an effective but fairly toxic regimen for the treatment of Hodgkin lymphoma (HL). Avascular necrosis (AVN) femoral head was previously reported to increase in patients treated with eBEACOPP, so far, no systematic analysis its frequency has been published.To analyse and identify possible risk factors AVN development eBEACOPP.We identified 26 eBEACOPP newly diagnosed high-risk advanced-stage HL, 25 whom were alive at time study. All invited participate a...
We investigated the association of HLA on clinical outcomes in our cohort patients haplo-HSCT program using HLAMatchmaker (EM) and PIRCHE score (PS) algorithms.The group comprised 64 (male = 35-54.7%, female 29-45.3%; median age 43 years) their related donors 30-46.9%, 34-53.1%). HLA-A/B/C/DRB1/DQB1/DPB1 loci were analyzed.Multivariate analysis between different or patient/donor-related parameters outcome revealed following associations with statistical significance: GvHD class I PS GvH...
Objectives: Serum chitotriosidase activity (CHIT1) is a biomarker of macrophage activation with an important role in inflammation-induced tissue remodeling and fibrosis. Macrophages have been described to play crucial regulating pathological erythropoiesis polycythemia vera (PV). The aim this study was evaluate CHIT1 patients diagnosed Philadelphia-negative myeloproliferative neoplasms (MPNs).Methods: Using fluorometric assay, we measured 28 PV, 27 essential thrombocythemia (ET), 17 primary...