A5065700566- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Chromium effects and bioremediation
- Catalysis for Biomass Conversion
- Aquatic Ecosystems and Phytoplankton Dynamics
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Mesoporous Materials and Catalysis
- Cancer, Hypoxia, and Metabolism
- Pesticide and Herbicide Environmental Studies
- Effects and risks of endocrine disrupting chemicals
- Chemical Synthesis and Reactions
- Prostate Cancer Treatment and Research
- Enzyme Catalysis and Immobilization
- Analytical Chemistry and Chromatography
- Radiopharmaceutical Chemistry and Applications
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Curcumin's Biomedical Applications
- Neuroscience of respiration and sleep
- Psoriasis: Treatment and Pathogenesis
- Mast cells and histamine
- Retinoids in leukemia and cellular processes
- High Altitude and Hypoxia
Shanghai Ocean University
2024
Shandong Agricultural University
2020-2022
Shanghai East Hospital
2020
Tongji University
2017
Shanghai Jiao Tong University
2013-2017
Second Military Medical University
2014-2017
Shanghai University of Sport
2014-2017
Changhai Hospital
2014-2016
Zhejiang University of Technology
2007-2008
Zhejiang University
2008
Despite the fact that biological processes of chiral compounds are enantioselective, endocrine disruption activity and uptake contaminants with respect to enantioselectivity has so far received limited research. In this study, estrogenic potential enantiomers a newer pyrethroid insecticide, bifenthrin (BF), were investigated. Significant differences in observed between two vitro human breast carcinoma MCF-7 cell proliferation assay (i.e., E-SCREEN assay) vivo aquatic vertebrate vitellogenin...
Water blooms caused by cyanobacteria are currently major global environmental issues. The outbreaks induced nutrient elements have attracted much attention; however, the effects of pollutants on themselves poorly understood, especially those due to chiral chemicals. To explore enantioselective eco-effects herbicide diclofop-methyl (DM) and its metabolite diclofop acid (DA), physiological characteristics Microcystis aeruginosa were investigated. results showed that using both biomass protein...
Research increasingly suggests that selectivity between enantiomers may exist in acute and chronic toxicological effects of chiral contaminants. In this study, we used the human breast carcinoma MCF-7 cell line to evaluate enantioselectivity o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT). Baseline separation o,p'-DDT was achieved on Chiralcel OJ column by high-performance liquid chromatography, absolute configuration optical rotation resolved were further identified. Significant differences...
Purpose: Hypoxia is an inevitable consequence of many respiratory diseases resulting from inadequate alveolar ventilation. As pulmonary dysfunction recently recognized as one the clinical features associated with diabetes, this study aims to investigate effect streptozotocin (STZ)-induced diabetes on hypoxia-induced lung injury. Materials and Methods: Mice were randomly allocated four groups (Control, Hypoxia, Diabetes, Diabetes+Hypoxia). Control type I diabetic (100 mg/kg STZ-treated) mice...
Abstract The acute and chronic toxicity of monocrotophos (MCP), the binary joint MCP bifenthrin (BF), sodium dodecyl benzene sulfonate (SDBS) to Daphnia magna (D. magna) was evaluated. 24 h-median effective concentration (24 h-EC50) 48 lethal (48 h-LC50) towards D. were 161 388 μ g/L, respectively. In addition, lowest-observed (LOEC) non-observed (NOEC) 10 5 Furthermore, value (ChV) against 7 g/L ratio (ACR) 55. number offspring per female intrinsic rate natural increase (r) identified as...
Prostate cancer is the commonest male malignancy in Western world, but its morbidity much lower China. The principal aim of this study was to evaluate frequency TMPRSS2:ERG fusion Chinese prostate patients using immunohistochemistry and reverse transcription polymerase chain (RT-PCR). In addition, we compared ERG protein expression with gene. relationship between clinicopathologic features also examined. Samples from who underwent radical prostatectomies Changhai Hospital (Shanghai, China)...
Cardiomyocyte death caused by hypoxia is one of the main causes myocardial infarction or heart failure, and mitochondria play an important role in this process. Agrimonolide (AM) a monomeric component extracted from Agrimonia pilosa L. has antioxidant, antitumor, anti-inflammatory effects. This study aimed to investigate mechanism AM improving hypoxia-induced H9c2 cell damage. The results showed that low concentrations promote proliferation increase cellular ATP content. Transcriptome...
ABSTRACT The potential Pb‐induced cytotoxicity in various tissues and biological systems has been reported. Some evidences also indicate that the Pb‐caused may be associated with nitric oxide synthase (NOS). However, there remains uncertainty about role of NOS signaling pathway during cytotoxicity. In this report, we provide data showing PbCl 2 treatment depresses expressions three distinct isoforms: neuronal (nNOS), endothelial (eNOS), inducible (iNOS) on both transcriptional translational...
The large amount of heavy metal chromium emissions from industrial production, ore smelting and sewage treatment plants have made one the most widespread pollutants, with Cr (VI) being toxic. In recent years, people gradually recognized great harm pollution, but research on its pathogenic mechanism is still not deep enough. this study, we treated Primary cells chicken liver to establish a model toxicity. optimal time concentration were screened using CCK-8 test. intracellular mitochondrial...
The global usage of veterinary antibiotics is significant. These can be released into the aquatic environment and exert toxic effects on non-target organisms. To explore physiological tetracycline life, growth characteristics toxin release from cyanobacterium Microcystis aeruginosa (M. aeruginosa) were studied. Results showed that toxicity order three target was TC (tetracycline) > CTC (chlortetracycline hydrochloride) OTC (oxytetracycline) in terms inhibition occurrence time EC10...
Veterinary antibiotics have been used extensively in many countries to treat diseases and protect the health of animals. As they are poorly adsorbed gut animals, majority excreted unchanged faeces urine. Therefore, antibiotic contaminants aquatic ecosystems may pose physiological effects on lives. In present study, growth inhibition oxidative damage cyanobacteria Microcystis aeruginosa exposed doxycycline hydrochloride were investigated. The results showed that could inhibit M. under...
Abstract Staphylococcus aureus is a common pathogen of bovine mastitis which can induce autophagy and inhibit flux, resulting in intracellular survival persistent infection. The aim the current study was to investigate role p38α induced by S. mammary epithelial cells. An infection model MAC-T cells constructed, activation examined after invasion. Through activating/inhibiting anisomycin/SB203580, autophagosomes, LC3 p62 level were analyzed immunofluorescence western blot. To further detailed...