A5081901402- Hypothalamic control of reproductive hormones
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Nuclear Structure and Function
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Obstructive Sleep Apnea Research
- T-cell and B-cell Immunology
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
- Adipose Tissue and Metabolism
- Organ Transplantation Techniques and Outcomes
- Transgenic Plants and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Adrenal Hormones and Disorders
- Sexual Differentiation and Disorders
- Polyomavirus and related diseases
- Myasthenia Gravis and Thymoma
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
University of Campania "Luigi Vanvitelli"
2021-2025
University of Calabria
2014-2024
University of Messina
2024
University of Chieti-Pescara
2003-2020
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2020
University of Bologna
2020
University of Naples Federico II
2020
University of Trieste
2020
University of Genoa
2010
University of Padua
2006
Flavonoids are a class of polyphenolic compounds widely distributed in the plant kingdom, which display variety biological activities, including chemoprevention and tumor growth inhibition. Our aim was to investigate effects several polyphenols on metastatic potential B16-BL6 melanoma cells vivo. Intraperitoneal administration quercetin, apigenin, (–)-epigallocathechin-3-gallate (EGCG), resveratrol, anti-estrogen tamoxifen, at time i.m. injection into syngeneic mice, resulted significant,...
Abstract Context There are only a few nationwide studies on boys with central precocious puberty (CPP) and the last Italian study is case series of 45 that dates back to 2000. Objective We aimed evaluate causes CPP in diagnosed during 2 decades Italy relative frequency forms associated nervous system (CNS) abnormalities magnetic resonance imaging (MRI) compared idiopathic ones. Methods performed national multicenter retrospective collecting data from 193 otherwise normal healthy diagnosis...
Background: Multiple genes can disrupt hypothalamic–pituitary axis development, causing multiple pituitary hormone deficiencies (MPHD). Despite advances in next-generation sequencing (NGS) identifying over 30 key genes, 85% of cases remain unsolved, indicating complex genotype–phenotype correlations and variable inheritance patterns. Objective: This study aimed to identify the MPHD genetics three probands from two unrelated families. Methods: Family A had one affected child, while B...
Castleman's disease is a lymphoproliferative disorder thought to be related deregulated production of IL-6. We have previously shown that mice lacking the trans-acting factor C/EBP beta, transcriptional regulator IL-6 and mediator intracellular signaling, develop pathology nearly identical multicentric disease, together with increasingly high levels circulating describe here how simultaneous inactivation both beta genes prevents development pathological traits observed in beta-deficient...
Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates beta-endorphin release and potentiates the effects secretagogues in AtT-20 cells, mouse anterior pituitary cell line. Treatment cells with IL-1 induced transient early stimulation mRNA expression by both immediate-early protooncogenes Fos Jun (mouse c-fos c-jun). The effect appeared within 30 min, returned to basal levels 2 hr. Desensitization protein kinase C phorbol ester pretreatment no on...
Pediatric obesity is associated with an increased risk of morbidity during childhood. Alongside the well-known metabolic syndrome, last decades scientific research has deeply investigated sleep breathing disorders. Among them, obstructive apnea (OSA) commonly affects children obesity. The presence OSA heightens impairment and weight gain. Therefore, it deserves specific treatment. However, polysomnography (PSG) not always available in clinical settings, alternative diagnostic tools are...
The COVID-19 pandemic has had a huge impact on children’s lifestyle and eating behaviour, resulting in an increase of obesity prevalence. CEBQ (Children’s Eating Behaviour Questionnaire) is validate questionnaire that investigates behaviour. Knowing the psychological consequences daily routine disruption during lockdown, we evaluated changes behaviours paediatric cohort before lockdown period through evaluation Italian version CEBQ. We prospectively enrolled children attending pediatric...
Platelets regulate several polymorphonuclear leukocyte (PMN) functions. We have found that thrombin-stimulated platelets potently inhibited PMN apoptosis. Cell-free supernatant from increasing concentrations of stimulated apoptosis in a dose-dependent manner, with an effect similar to corresponding platelets. At the plateau, platelet by 54.6 +/- 6.8%, anti-apoptotic activity being higher than GM-CSF and comparable LPS. Neither IL-1ra nor combination anti-IL1alpha + betamAb affected...
Abstract Primary IgA nephropathy (IgAN) diagnosis is based on IgA-dominant glomerular deposits and histological scoring done formalin-fixed paraffin embedded tissue (FFPE) sections using the Oxford classification. Our aim was to use this underexploited resource extract RNA identify genes that characterize active (endocapillary–extracapillary proliferations) chronic (tubulo-interstitial) renal lesions in total cortex. extracted from archival FFPE biopsies of 52 IgAN patients, 22 non-IgAN...
Fixation of APC with 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (ECDI) eliminates their ability to stimulate proliferation alloreactive T cells or the D10 cell clone, although a partial response, IL-4 production, was measured. However, if were activated before fixation, they could be ECDI-fixed and retain induce proliferation. IL-1, LPS capable activating in this way, whereas IFN-gamma not. This activation step occurred 6 h, required protein synthesis, distinct from increases Ia IL-1....
Abstract Background Genetic and environmental factors are implicated in many developmental processes. Recent evidence, however, has suggested that epigenetic changes may also influence the onset of puberty or susceptibility to a wide range diseases later life. The present study aims investigate genomic DNA methylation profiles associated with pubertal analyzing human peripheral blood leukocytes from three different groups subjects: 19 girls central precocious (CPP), 14 healthy prepubertal...
The main purpose of the study is to assess association between obstructive sleep apnea (OSA) and insulin secretion in children with obesity.We enrolled adolescents who attended our pediatric clinic because obesity OSA. Glucose homeostasis was assessed through standard 2-h oral glucose tolerance test (OGTT). Nocturnal cardio-respiratory polygraphy performed for OSA diagnosis. Twenty-two patients underwent a 3-h OGTT investigate sensitivity oral-minimal model.seventy-seven were included study....
Abstract Human thymus is composed of several discrete compartments. Stage III thymocytes, located mainly in the medulla, stain brightly with anti-T3 monoclonal antibody; stage II cortex, are T3- but react T6 antibodies. The earliest identifiable intrathymic cell (stage I) expresses sheep erythrocyte glycoprotein T11 not or T3 antigens. Within a phenotypically heterogeneous pool proliferating lymphoblasts present. This capacity to proliferate without vitro activation attributable thymocytes...
Abstract Background Prokineticin receptor 2 ( PROKR2 ) loss of function mutations have been described as cause hypogonadotropic hypogonadism. In 2017, a first case central precocious puberty (CPP) caused by heterozygous gain mutation was in 3.5 years-old girl. No other cases reported yet. This study performs molecular screening girls with early onset CPP (breast budding before 6 years age) to identify possible alterations . Methods We analysed DNA 31 idiopathic diagnosed via basal LH levels...