A5100774383- Pancreatic function and diabetes
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
- Genomic variations and chromosomal abnormalities
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Shoulder Injury and Treatment
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- Shoulder and Clavicle Injuries
- Silk-based biomaterials and applications
- Glioma Diagnosis and Treatment
- Gene expression and cancer classification
- Carbon and Quantum Dots Applications
- Epigenetics and DNA Methylation
- Skin Protection and Aging
- Soil Mechanics and Vehicle Dynamics
- Genomics and Phylogenetic Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Tissue Engineering and Regenerative Medicine
- Peripheral Nerve Disorders
Centre National de la Recherche Scientifique
2017-2023
Jeonbuk National University
2023
Institut Jacques Monod
2017-2023
Université Paris Cité
2017-2023
Institut Gustave Roussy
2023
Université Paris-Saclay
2023
Chonnam National University
2020
Dongshin University
2020
Kwangju Women's University
2020
Sorbonne Paris Cité
2017
High proliferation rate and high mutation density are both indicators of poor prognosis in adrenocortical carcinomas. We performed a hypothesis-driven association study between clinical features carcinomas the expression levels 136 genes involved DNA metabolism G1/S phase transition. In 79 samples downloaded from The Cancer Genome Atlas portal, Cyclin Dependent Kinase 6 (CDK6) mRNA gave most significant with shorter time to relapse poorer survival patients. A hierarchical clustering approach...
Comparative genomic hybridization (CGH) microarrays have been used to determine copy number variations (CNVs) and their effects on complex diseases. Detection of absolute CNVs independent variants an arbitrary reference sample has a critical issue in CGH array experiments. Whole genome analysis using massively parallel sequencing with multiple ultra-high resolution arrays provides opportunity catalog highly accurate the DNA (NA10851). Using information variants, we developed new method,...
High-throughput genomic technologies have been used to explore personal human genomes for the past few years. Although integration of is important high-accuracy detection variations, no databases prepared systematically archive and facilitate comparison data sets using a variety experimental platforms. We describe here Total Integrated Archive Short-Read Array (TIARA; http://tiara.gmi.ac.kr ) database, which contains information obtained from next generation sequencing (NGS) techniques...
Abstract DNA replication must be faithful and follow a well-defined spatiotemporal program closely linked to transcriptional activity, epigenomic marks, intranuclear structures, mutation rate cell fate determination. Among the readouts of replication, timing analyses require not only complex time-consuming experimental procedures, but also skills in bioinformatics. We developed dedicated Shiny interactive web application, START-R (Simple Tool for Analysis Replication Timing based on R)...
Summary Replication stress, a major hallmark of cancers, and ensuing genome instability source from impaired progression replication forks. The first line defense against fork slowing is compensation, long-described process that elicits firing otherwise dormant origins. It remains unclear whether compensation requires activation the DNA checkpoint or passively results lengthening window time during which origins can fire when slows, both. Using molecular combing we show here linear...
Purpose: The aim of this study was to evaluate the possibility for clinical use delirium assessment tools, Nursing Delirium Screening Scale (Nu-DESC) and Observation (DOS), postoperative neurosurgery patients. Methods: A sample 100 elderly patients post recruited from a ward in university hospital located Seoul, South Korea. Nurses (n=28) on were asked assess participants using Nu-DESC DOS. Based diagnosis made by neuropsychiatrist, validity tools evaluated. questionnaire about ease tool...
In this study, we synthesized fluorescent europium oxide (Eu2O3) nanosheets (EuNSs) using different approaches such as chemical-based methods and green synthesis, Dedleya brittonii (DB) extract an effective chelating agent for biological preparation. A modified hydrothermal method was used to synthesize chemical Eu2O3 (CH-EuNS) DB extract-based (DB-EuNS). Field emission scanning electron microscopy HR-TEM analyses revealed that both EuNS had a sheet-like morphology, with average thickness of...
Background Although numerous measurement methods exist for thoracolumbar spine rotation, achieving an accurate of axial-thoracolumbar rotation is difficult because it usually measured in the open kinematic chain. Purpose Therefore, purpose our study was to investigate reliability a new method measuring closed Study design Intra-tester repeated measures Methods 14 healthy participants performed rotation. An electromagnetic tracking system used measure angle sternum’s jugular notch and xiphoid...
Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies demonstrated that efficiently block pRb-E2F pathway induce cell cycle arrest in pRb-proficient cells. Based on these studies, been approved by FDA for treatment of advanced hormonal receptor (HR) positive breast cancers combination with therapy. However, some evidence has recently shown unexpected effects inhibitors, underlining a need to characterize...
Abstract DNA replication must be faithful and follow a well-defined spatio-temporal program closely linked to transcriptional activity, epigenomic marks, intra-nuclear structures, mutation rate cell fate determination. Among the readouts of program, timing (RT) analyses require complex, precise time-consuming experimental procedures, study large-size computer files. We improved RT protocol speed it up increase its quality reproducibility. Also, we partly automated developed user-friendly...