A5075648724- Virology and Viral Diseases
- Respiratory viral infections research
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Functional Brain Connectivity Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Decision-Making and Restraints
- Emergency and Acute Care Studies
- Electrolyte and hormonal disorders
- Traumatic Brain Injury Research
- Influenza Virus Research Studies
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Pharmaceutical Practices and Patient Outcomes
- Ion channel regulation and function
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Cardiac electrophysiology and arrhythmias
Tufts University
2019-2024
Tufts Medical Center
2019-2024
Hesco (United States)
2021
Columbia University Irving Medical Center
2019
Traumatic brain injury (TBI) is the leading cause of death in young people and can cognitive motor dysfunction disruptions functional connectivity between regions. In human TBI patients rodent models TBI, decreased after injury. Recovery associated with improved cognition memory, suggesting an important link outcome. We examined widespread alterations following using simultaneous widefield mesoscale GCaMP7c calcium imaging electrocorticography (ECoG) mice injured controlled cortical impact...
Human parainfluenza virus 3 (HPIV3) and respiratory syncytial (RSV) cause lower infection in infants young children. There are no vaccines for these pathogens, existing treatments have limited or questionable efficacy. Infection by HPIV3 RSV requires fusion of the viral cell membranes, a process mediated trimeric glycoprotein (F) displayed on envelope. Once triggered, pre-fusion form F undergoes series conformational changes that first extend molecule to allow insertion hydrophobic peptide...
Postintensive care syndrome (PICS) has been identified in a large proportion of medical intensive unit survivors; however, the occurrence surgical (SICU) survivors is unknown. We implemented multidisciplinary critical outpatient clinic (CCOC) to identify PICS SICU survivors.Seventy acute surgery and trauma patients, 18 years or older, who remained for 72 hours longer at Level I center were seen CCOC 2 weeks, 12 24 weeks after hospital discharge. The staffing included nurse coordinator,...
Paramyxoviruses, specifically, the childhood pathogen human parainfluenza virus type 3, are internalized into host cells following fusion between viral and target cell membranes. The receptor binding protein, hemagglutinin (HA)-neuraminidase (HN), protein (F) facilitate entry through a coordinated process involving HN activation by binding, which triggers conformational changes in F to activate it reach its fusion-competent state. Interfering with this premature of has been shown be an...
Post-intensive care unit (ICU) syndrome (PICS) occurs at an exorbitant rate in surgical ICU (SICU) survivors. It remains unknown if critical illness due to trauma versus acute surgery (ACS) may represent different pathophysiologic entities. In this longitudinal study, we determined admission criteria a cohort of and ACS patients were associated with differences the occurrence PICS.Patients 18 years or older, admitted Level I center services, remained SICU for ≥72 hours, seen Recovery Center...
Abstract Parvalbumin-positive interneurons (PV-INs) regulate neuronal and circuit activity, their dysfunction is observed across neurological conditions, including traumatic brain injury (TBI), epilepsy, Alzheimer’s disease, schizophrenia. PV-INs are particularly vulnerable to cell loss, potentially due increased metabolic demands arising from uniquely high level of electrical which render them susceptible pressure. Here, we use single-nucleus RNA-sequencing (snRNAseq) data a rodent model...
ABSTRACT Traumatic brain injury (TBI) is the leading cause of death in young people and can cognitive motor dysfunction disruptions functional connectivity between regions. In human TBI patients rodent models TBI, decreased after injury. Recovery associated with improved cognition memory, suggesting an important link outcome. We examined widespread alterations following using simultaneous widefield mesoscale GCaMP7c calcium imaging electrocorticography (ECoG) mice injured controlled cortical...
Mahoney, Eric; Bottom-Tanzer, Samantha; Louzada, Maria Teresa; Poyant, Janelle; Boudouvas, Abbey; Ahmed, Sana; Hojman, Horacio; Bugaev, Nikolay; Johnson, Benjamin; Levasseur-Franklin, Kimberly; Lisa Van Kirk, Anna; Daniel, Eryn; Poon, Eileen; Emoff, Caroline Author Information
Poyant, Janelle; Bottom-Tanzer, Samantha; Louzada, Maria Teresa; Emoff, Caroline; Ahmed, Sana; Boudouvas, Abbey; Poon, Eileen; Mahoney, Eric Author Information