A5027146239- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Spine and Intervertebral Disc Pathology
- Retinoids in leukemia and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Metabolomics and Mass Spectrometry Studies
- Spinal Fractures and Fixation Techniques
- Pharmacological Effects of Natural Compounds
- Cervical and Thoracic Myelopathy
- AI in cancer detection
- Vitamin C and Antioxidants Research
- Genetic Associations and Epidemiology
- Multiple Myeloma Research and Treatments
- Diabetes and associated disorders
- Neural Networks and Applications
- Vitamin D Research Studies
- Youth Development and Social Support
- Canadian Policy and Governance
- Electrolyte and hormonal disorders
- Lipoproteins and Cardiovascular Health
- Higher Education Practises and Engagement
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
Children's Hospital of Philadelphia
2024
Sequoia Hospital
2024
Bristol-Myers Squibb (United States)
2024
Tufts University
2021-2024
Swarthmore College
2022
Williams College
2021
Shepherd University
2021
Vanderbilt University Medical Center
2019
UC San Diego Health System
2019
Emory University Orthopaedics and Spine Hospital
2019
The Infinium DNA Methylation BeadChips have significantly contributed to population-scale epigenetics research by enabling epigenome-wide trait association discoveries. Here, we design, describe, and experimentally verify a new iteration of this technology, the Screening Array (MSA), focus on human screening discovery. This array utilizes extensive data from previous platform-based studies (EWAS). It incorporates knowledge latest single-cell cell type-resolution whole genome methylome...
Multiple studies have demonstrated a strong correlation between sagittal malalignment and health-related quality of life measures. Thus, correction vertical axis (SVA), pelvic tilt (PT), lumbar lordosis-pelvic incidence (LL-PI), T1 spinopelvic inclination (T1SPi) become primary objective adult spinal deformity surgery. Anterior column realignment (ACR) has emerged as less invasive technique while the addition posterior osteotomies shown greater in ACR, it is unknown if pre-ACR release...
Abstract Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium (K + ) from the extracellular space following activity. Astrocyte clearance of both K is voltage-dependent, but astrocyte membrane potential (V m has been thought to be largely invariant. As a result, these voltage-dependencies have not considered relevant function. Using genetically encoded voltage indicators enabling measurement V at processes...
Abstract Ex vivo model systems using tumor biopsies from patients are often utilized to develop predictive biomarkers. However, these readouts proximal and do not inform on downstream mechanisms (distal pharmacodynamics) their relationship anti-tumor efficacy. In murine models represent a powerful tool bridge this gap. selection of an appropriate translationally relevant can be time-consuming process given that the complexity microenvironment (TME). Additionally, in generally amenable high...
Abstract Parvalbumin-positive interneurons (PV-INs) regulate neuronal and circuit activity, their dysfunction is observed across neurological conditions, including traumatic brain injury (TBI), epilepsy, Alzheimer’s disease, schizophrenia. PV-INs are particularly vulnerable to cell loss, potentially due increased metabolic demands arising from uniquely high level of electrical which render them susceptible pressure. Here, we use single-nucleus RNA-sequencing (snRNAseq) data a rodent model...
Abstract One key function of the innate immune response is rapid detection and elimination microbial invaders, which can be influenced by micronutrients. A role for vitamin in host defense against Mycobacterium tuberculosis has been suggested through epidemiological vitro studies; however, antimicrobial mechanism remained unclear. Here, we demonstrate that treatment M. tuberculosis-infected human monocytes with either all-trans retinoic acid (ATRA) or 1,25-dihydroxyvitamin D, biologically...
Guiding students to become responsible citizens is a world-wide goal in universities. Universities three parts of the world share commonalities their programs which are given opportunities use and develop skills knowledge relating others different types communities, one within university setting two into communities external setting. Gaining experiences being citizen community key characteristic programs.
Abstract Understanding the innate immune response to Mycobacterium tuberculosis, is a key step development of effective immunotherapies for tuberculosis (TB). Epidemiological evidence correlates low serum vitamin A (retinol) levels active TB; however, retinol biologically inactive. Previously, we demonstrated that stimulation M. b-infected macrophages with hormone, all-trans retinoic acid (ATRA), triggers NPC2-dependent antimicrobial activity. Therefore, understanding mechanism by which...
The current standard of inflammatory bowel disease (IBD), especially, Crohn’s (CD), diagnosis is set through an invasive endoscopy procedure. However, serum metabolites hold potential as useful biomarkers for non-invasive and treatment IBDs. goal this research was to elucidate the including genes related IBDs, show their distinguishing common features, create a machine-learning (ML) model recognition each disease. We explored metabolic pathways gene–metabolite networks unspecified-IBD...