A5103229939- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Acute Lymphoblastic Leukemia research
- Thermal Regulation in Medicine
- Acute Myeloid Leukemia Research
- Homelessness and Social Issues
- Retinoids in leukemia and cellular processes
- Atomic and Subatomic Physics Research
- Peroxisome Proliferator-Activated Receptors
- Kruppel-like factors research
- Substance Abuse Treatment and Outcomes
- Hemoglobinopathies and Related Disorders
- Pneumonia and Respiratory Infections
- Epilepsy research and treatment
- Renal Diseases and Glomerulopathies
- Cardiac, Anesthesia and Surgical Outcomes
- Alcohol Consumption and Health Effects
- Chronic Kidney Disease and Diabetes
- Cholesterol and Lipid Metabolism
- Retinal Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Hematopoietic Stem Cell Transplantation
- Retinal Development and Disorders
Massachusetts General Hospital
2012-2024
Harvard University
2019-2024
Massachusetts Eye and Ear Infirmary
2024
Smith-Kettlewell Eye Research Institute
2024
University of Oxford
2023
University of Arizona
2023
MaineGeneral Medical Center
2021
Dermatology Research Center
2020
Advanced Radiation Centers of New York
2010
University of Pittsburgh
1999
To compare the effectiveness of antiepileptic drugs (AEDs) for use in older adults with epilepsy.Retrospective review.Columbia Comprehensive Epilepsy Center, New York, York.Four hundred seventeen outpatients 55 years and newly taking any 10 most commonly prescribed AEDs between 2000 2005.The percentage patients who remained AED 12 or more months (12-month "retention"). We also measured efficacy seizure freedom) adverse effects leading to dose change. Retention seizure-freedom rates were...
Traumatic brain injury (TBI) causes cortical dysfunction and can lead to posttraumatic epilepsy. Multiple studies demonstrate that GABAergic inhibitory network function is compromised following TBI, which may contribute hyperexcitability motor, behavioral, cognitive deficits. Preserving the of interneurons, therefore, a rational therapeutic strategy preserve after TBI prevent long-term clinical complications. Here, we explored an approach based on ketogenic diet, neuroprotective...
Rationale CC16 (club cell secretory protein) is a pneumoprotein produced predominantly by pulmonary club cells. Circulating associated with protection from the inception and progression of two most common obstructive lung diseases (asthma chronic disease). Objectives Although exact mechanisms remain elusive, studies consistently suggest causal role in mediating antiinflammatory antioxidant functions lung. We sought to determine any novel receptor systems that could participate CC16's...
Abstract Degeneration of the macula is associated with several overlapping diseases including age-related macular degeneration (AMD) and Stargardt Disease (STGD). Mutations in ATP Binding Cassette Subfamily A Member 4 ( ABCA4 ) are late-onset dry AMD early-onset STGD. Additionally, both forms exhibit deposition subretinal material photoreceptor degeneration. Retinoic acid related orphan receptor α RORA regulates inflammation pathway that includes ABCA4, CD59, C3 C5 . In this translational...
The transcription factor SREBP2 is the main regulator of cholesterol homeostasis and central to mechanism action lipid-lowering drugs, such as statins, which are responsible for largest overall reduction in cardiovascular risk mortality humans with atherosclerotic disease. Recently, has been implicated leukocyte innate adaptive immune responses by upregulation flux or direct transcriptional activation pro-inflammatory genes. Here, we investigate role endothelial cells (ECs), since ECs at...
Cultures of normal lymphocytes were induced to transform by pokeweed mitogen (PWM). Inhibition transformation was observed when these cultures contained sera isolated from children with acute lymphoblastic leukemia (ALL). The inhibition best demonstrated the concentration leukemic serum in culture medium relatively high (60 percent); however, also a more standard (20 percent). Not all inhibitory. Pretreatment newly diagnosed patients leukocyte counts greater than 50,000/mm3 significantly...
Pr e sen tat ion of C a seA 16-year-old girl was admitted to this hospital because trauma and extensive burns sustained in motor-vehicle accident.The patient had been well until the day admission when, while driving alone restrained with seat belt, her vehicle collided at high speed tree burst into flames.She reportedly blunt head trapped burning windows closed for approximately 10 minutes, extricated by passersby who shattered window.She initially awake severe pain.Emergency medical service...
Abstract Parvalbumin-positive interneurons (PV-INs) regulate neuronal and circuit activity, their dysfunction is observed across neurological conditions, including traumatic brain injury (TBI), epilepsy, Alzheimer’s disease, schizophrenia. PV-INs are particularly vulnerable to cell loss, potentially due increased metabolic demands arising from uniquely high level of electrical which render them susceptible pressure. Here, we use single-nucleus RNA-sequencing (snRNAseq) data a rodent model...
Abstract: ARDS related to gadolinium contrast is rare and there have only been five previously reported cases in adults. We describe the first case our knowledge of pediatric acute lung injury administration. report on a healthy 10-year-old boy Pediatric Intersive Care Unit who was recovering from staphylococcus aureus sepsis when he developed hypoxemic respiratory failure three hours after intravenous administration for brain magnetic resonance imaging. A chest radiograph demonstrated new...
Society of Critical Care Medicine; 28th Educational and Scientific Symposium; San Francisco, California, USA; January 23-27, 1999: Poster Symposia Presentations
Society of Critical Care Medicine; 28th Educational and Scientific Symposium; San Francisco, California, USA; January 23-27, 1999: Poster Presentations: Hall
GM1 gangliosidosis is an autosomal recessive lysosomal storage disease, caused by a deficiency in the enzyme β-galactosidase. The disease affects CNS, liver, kidney, heart and skeletal system, leading to severe neurodegeneration death. We propose treat this disorder using ex vivo hematopoietic stem cell therapy. effectiveness of therapy requires recruitment transduced donor cells CNS. This only found occur after mice are conditioned with total body irradiation, due increase CNS cytokine...
This is a protocol to describe the materials and methods utilized perform preclinical traumatic brain injury (TBI) using closed head model in mice. The posting of this part mission PREClinical Interagency reSearch resourcE-TBI (PRECISE-TBI, precise-tbi.org) improve clinical translation therapeutics by providing an online catalog standardized protocols reduce variability usage between laboratories.
Kochanek, P.; Clark, R.; Dixon, C. E.; Whalen, M.; Carlos, T.; Jackson, Hendrich, K.; Ho, C.; Graham, S.; DeKosky, Marion, D. Author Information