A5100352664- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Bone health and treatments
- Bone and Joint Diseases
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Analysis
- Thermochemical Biomass Conversion Processes
- Orthopedic Infections and Treatments
- Advanced Photocatalysis Techniques
- Bone and Dental Protein Studies
- TGF-β signaling in diseases
- Musculoskeletal pain and rehabilitation
- Catalytic Processes in Materials Science
- Mesenchymal stem cell research
- Gout, Hyperuricemia, Uric Acid
- Flavonoids in Medical Research
- Peroxisome Proliferator-Activated Receptors
- Coal and Its By-products
- Pancreatic function and diabetes
- Clinical practice guidelines implementation
- Cervical and Thoracic Myelopathy
- Apelin-related biomedical research
- NF-κB Signaling Pathways
- Power System Optimization and Stability
Guangxi University of Chinese Medicine
2021-2025
Ruikang Affiliated Hospital of Guangxi Medical University
2022-2025
Guangxi University
2016-2022
Henan University of Engineering
2022
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2016-2021
Changchun University
2019
Chinese Academy of Sciences
2018
Institute of Hydrobiology
2018
University of Chinese Academy of Sciences
2018
Stomatology Hospital
2017
Mesenchymal stem cell commitment to an osteoprogenitor lineage requires the activity of Runx2, a molecule implicated in etiopathology multiple congenital craniofacial anomalies. Through promoter analyses, we have recently identified new direct transcriptional target Nell-1, craniosynostosis (CS)-associated with potent osteogenic properties. This study investigated mechanistic and functional relationship between Nell-1 Runx2 regulating osteoblast differentiation. The results showed that...
Icariin is commonly used for the clinical treatment of osteonecrosis femoral head (ONFH). miR-23a-3p plays a vital role in regulating osteogenic differentiation bone marrow-derived mesenchymal stem cells (BMSCs). The present study aimed to investigate roles icariin and BMSCs an ONFH model. were isolated cultured vitro using icariin-containing serum at various concentrations, also transfected with miR-23a inhibitor. alkaline phosphatase (ALP) activity cell viability as well BMP-2/Smad5/Runx2...
ABSTRACT Aim Through the use of network toxicology, research sought to determine whether cellular senescence and associated molecular mechanisms in nicotine‐induced intervertebral disc degeneration (IVDD) were potentially harmful. Methods The primary chemical structure 105 targets action nicotine determined by using Swiss Target Prediction, Cell Age, PubChem databases. 855 IVDD genes found GEO Age datasets. Results After additional screening Cytoscape development, 9 key identified....
Schematic diagram of fabricating process NSCDBC/MIL-125(Ti).
Abstract Adipose tissue‐derived mesenchymal stem cells (ASCs) from livestock are valuable resources for animal reproduction and veterinary therapeutics. Previous studies have shown that hypoxic conditions were beneficial in maintaining the physiological activities of ASCs. However, effects hypoxia on buffalo ASCs (bASCs) remain unclear. In this study, proliferation, stemness, reprogramming into induced pluripotent (iPSCs) bASCs examined. The results showed culture (5% oxygen) enhanced...
Nell-1, first identified by its overexpression in synostotic cranial sutures, is a novel osteoinductive growth and differentiation factor. To further define Nell-1's role craniofacial patterning, we characterized defects of the ENU-induced Nell-1–deficient (END) mice, focusing on both intramembranous endochondral bones. Results showed that calvarial bones neonatal END mice were reduced thickness density, with phenotype resembling cleidocraniodysplasia. In addition, global reduction...
NELL-1 is a novel secreted protein associated with premature fusion of cranial sutures in craniosynostosis that has been found to promote osteoblast cell differentiation and mineralization. Our previous study showed Runx2, the key transcription factor differentiation, transactivates promoter. In this study, we evaluated regulatory involvement mechanisms Osterix, an essential osteoblasts, gene expression function. Promoter analysis cluster potential Sp1 sites (Sp1/Osterix binding sites)...
This paper concerns a class of mean field stochastic differential equations driven by fractional Brownian motion with Hurst parameter H∈(1/2,1). The existence and uniqueness almost automorphic solutions in distribution are established provided coefficients satisfy some suitable conditions.
Cleidocranial dysplasia (CCD) is an autosomal dominant disease that affects the skeletal system. Common symptoms of CCD include hypoplasia or aplasia clavicles, delayed even absent closure fontanels, midface hypoplasia, short stature, and eruption permanent supernumerary teeth. Previous studies reported a connection between haploinsufficiency runt-related transcription factor 2 (RUNX2). Here, we report sporadic Chinese case presenting typical CCD.We made genetic testing on this identified...
Icariin has attracted increasing attention because of its wide variety pharmacological effects.This study investigates whether icariin could promote fracture healing in young and old rats mechanisms.A Wistar rat model for the tibia relatively rats, respectively, was established. The were divided into four groups: group, L-icariin (50 mg/kg icariin), M-icariin (100 icariin) H-icariin (200 intragastric administration performed 10 days or 20 days. In addition, isolated cultured bone mesenchymal...
Abstract Objective To identify differentially expressed lncRNA, miRNA, and mRNA during the pathogenesis of gout, explore ceRNA network regulatory mechanism seek potential therapeutic targets. Method First, gout‐related chips were retrieved by GEO database. Then, analysis lncRNAs mRNAs was conducted R language other software. Besides, miRNA its regulated predicted based on public databases, intersection predicated taken, lncRNA‐miRNA‐mRNA relationships obtained to construct network....
Clinically, the traditional Chinese medicine compound Gujiansan has been widely used in treatment of steroid-induced avascular necrosis femoral head (SANFH). The present study aimed to investigate mechanisms underlying therapeutic effect Gujiansan.A rat model SANFH was established by injection dexamethasone (DEX) at a high dosage 25 mg/kg/d. Then, intragastrically administered for 2 weeks, 4 and 8 histological examination performed. expression levels related mRNAs proteins were analyzed...
The study aimed to the differential gene expression and immune cell infiltration in patients with steroid-induced necrosis of femoral head (SANFH), identify key genes cells SANFH, explore relationship between SANFH.
Past researches have shown that pluripotency maintenance of naive and primed-state pluripotent stem cells (PSCs) depends on different signaling pathways, naive-state PSCs possess the ability to produce chimeras when they are introduced into a blastocyst. Considering porcine is an attractive model for preclinical studies, many about pig induced (piPSCs) been reported. Some cytokines small molecule compounds could transform primed piPSCs state. However, there no suitable culture conditions...
<title>Abstract</title> Objective To study the differential gene expression and immune cell infiltration in patients with steroid-induced necrosis of femoral head (SANFH), identify key genes cells SANFH, explore relationship between SANFH. Methods The high-throughput chip dataset GSE123568 was downloaded from GEO database, analyzed R language. STRING database Cytoscape software were used to analyze protein interaction network screen genes, enrichment analysis made on genes. SANFH verified by...
With increasing demand for electricity and renewable energy, tie-line power exchanges among interconnected networks facilitate the efficient utilization of resources. Exact description feasible region guarantees security in dispatching. However, because existence nonlinear constraints, is usually complex. This paper proposes an approximation method to characterize original considering constraints such as transmission capacity limit. A sufficient number boundary points are obtained through...