A5063147456- Saffron Plant Research Studies
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Cell Adhesion Molecules Research
- Bioactive natural compounds
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Flavonoids in Medical Research
- Plant tissue culture and regeneration
- PI3K/AKT/mTOR signaling in cancer
- Natural product bioactivities and synthesis
- Hypothalamic control of reproductive hormones
- Phytochemicals and Antioxidant Activities
- Glycosylation and Glycoproteins Research
- Ovarian function and disorders
- Quantum Computing Algorithms and Architecture
- Phytochemical Studies and Bioactivities
- Plant Reproductive Biology
- RNA modifications and cancer
- Quantum-Dot Cellular Automata
- Genetic factors in colorectal cancer
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Plant-Microbe Interactions and Immunity
- Biological Activity of Diterpenoids and Biflavonoids
University of Kashmir
2015-2025
Cluster University Srinagar
2014
Diversité, adaptation et développement des plantes
2010
Institut de Recherche pour le Développement
2010
The present study aimed to perform phytochemical investigation of various fractions the aerial parts Senecio laetus Edgew for its bio-constitution and pharmacologically evaluate these antioxidant antiproliferative activities against breast cancer (MCF-7) colon carcinoma (HCT-116) cell lines. Phytochemical screening characterization compounds was carried out as per standard procedures. Extracts were subjected GC-MS analysis identification constituents. activity using DPPH, ferric ion reducing...
Abstract Background Tumor cell-monocyte interactions play crucial roles in shaping up the pro-tumorigenic phenotype and functional output of tumor-associated macrophages. Within tumor microenvironment, such heterotypic cell–cell are known to occur via secretory proteins. Secretory proteins establish a diabolic liaison between cells monocytes, leading their recruitment, subsequent polarization consequent progression. Methods We co-cultured model lung adenocarcinoma cell line A549 with THP-1...
Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity tumor cells by engaging cell surface α9β1 integrins. This interaction mediated the C-C loop EDA activates pro-oncogenic signaling pathways leading to epithelial mesenchymal transition (EMT) cells, thus signifying its importance in control progression. In this context present study was designed explore active compounds from selected ethno-medicinal plants western Himalayan region for...
Walnuts are one of the healthiest foods in world because they best sources beneficial nutrients, minerals, and antioxidants. They also contain key energy. Despite several traditional uses, leaves Juglans regia L. have received little attention regarding phytochemical pharmacological potential. Thus, current study intended to find walnut genotypes with greatest antioxidant, anticancer, antifungal activity. The total polyphenolic, flavonoid, flavanol contents from 14 were determined. Genotypes...
des établissements d'enseignement et de recherche français ou étrangers, laboratoires publics privés.
In this study, we investigated the antibacterial and antioxidant activities of Crocus sativus L. Kashmirianus c.v. extracts (callus stigmas). Profuse callus was obtained on MS medium enriched with BAP (20 μ M)+NAA (15 M) under in vitro conditions from corm slices. Four pathogenic bacterial strains (Staphylococcus aureus CD0001, Escherichia coli CD0006, Pseudomonas aeruginosa CD0023 Shigella flexneri CD0033) were used for determining activity extracts. The determined by DPPH assay, DNA...
Proteomic analysis using multiplex affinity reagents is perhaps the most reliable strategy to capture differentially expressed proteins that are slightly or immensely modified. In addition expressional variation, it comprehensively evident immunogenicity of a protein can be deciding factor for instigating an inflammation afflicted-carcinogenesis. Considering both these factors, simple and systematic was designed immunogenic cancer biomarkers from sera colorectal patients. The reagent, in...
Iris kashmiriana, a medicinal plant growing under Kashmir conditions, has been found very useful for pulmonary asthma, cancer, inflammation, liver and uterine diseases in traditional medicine. The importance of the prompted isolation variety pharmacologically active compounds including quinones, triterpenoids, flavonoids, isoflavonoids stilbene glycosides. To evaluate antiproliferative antioxidant potential methanolic extract rhizomes I. kashmiriana. effect kashmiriana was evaluated against...
Bioactive (2<italic>S</italic>,4<italic>R</italic>)-3-(<italic>tert</italic>-butoxycarbonyl)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid molecules restructure enzymes through complexation, allowing enhancing their activity to protect cells from oxidative stress.
Abstract Tumor‐associated macrophages (TAMs) play a pivotal role in facilitating tumor growth and metastasis. This tumor‐promoting propensity of TAMs sets as result their complex cross‐talk with cells mediated primarily by cell‐secreted proteins the microenvironment. To explore such interactions, we employed an immunoscreening approach involving immunization Balb‐c mice model human lung carcinoma cell line, A549. From serological examination combined mass spectrometric analysis,...
ABSTRACT The shortcomings of the licensed polysaccharide-based pneumococcal vaccine are driving efforts toward development a protein-based that is serotype independent and effective in all age groups. An opsonophagocytic killing assay (OPKA) used to evaluate antibody response against vaccines. However, OPKA not reliable for noncapsular antigens. Thus, there need develop an vitro surrogate protection protein candidates like surface antigen A (PspA). PspA serologically variable cell virulence...
Quantum dot Cellular Automata (QCA), an advanced nanotechnology, is a branch of nano-electronics that attempts to create general computation at nano scale by controlling the position electrons. The basic logic in QCA does not use voltage level for representation; rather it represents binary state polarization electrons Cell, which building block QCA. technology has large potential provide high space density, ultra-low power dissipation enables us build circuits with faster speed, smaller...
O6-methylguanine-DNA methyltransferase (MGMT) is one of the major DNA repair protein that counteracts alkalyting agent-induced damage by replacing O6-methylguanine (mutagenic lesion) back to guanine, eventually suppressing mismatch errors and double strand crosslinks. Exonic alterations in form nucleotide polymorphism may result altered structure turn can lead loss function. In present study, we focused on population feared for high exposure alkylating agents owing their typical specialized...
Lychnis coronaria, a perennial (herbaceous) belonging to Caryophyllaceae has been traditionally used for treating different complications. However, the free radical scavenging effect, anti-inflammatory activity and anticancer property of methanolic extract this plant not addressed. Most importantly, chemical constituents present in coronaria responsible its diverse activities have scrutinized till date. Here, we complex approach exploring above mentioned effects coronaria. We performed...
An important factor in the performance of out-planted conifers is association plant roots with ectomycorrhizal (EcM) fungi. However, limited information available about diversity root-associated EcM fungi Pinus wallichiana A.B. Jackson, a coniferous species endemic to Himalayan forests that has hampered reforestation programs area. The study was carried at three major forest areas Kashmir Himalaya believed be pure stands P. wallichiana. Fine root tips harbouring were collected and processed...
Tetranectin-plasminogen interaction plays a defining role in extracellular matrix degradation, enabling tumor cell invasion and metastasis. This occurs via the carbohydrate recognition domain (CRD) Kringle 4 of tetranectin plasminogen, respectively, leading to activation plasminogen-cascade that triggers proteolytic processes. Thus targeting this represents an important strategy suppress migration invasion. In direction, we attempted target CRD inhibit its with Kringle-4 plasminogen using...
Background: Cancer loci comprise heterogeneous cell populations with diverse cellular secretions.Therefore, disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards.Materials and Methods: In this study, 2DE proteomic profiles were examined of 13 lung-adenocarcinoma samples matched the A549 line proteome.A549 matched-cancer-specific hits analyzed characterized by...