A5001417481- Essential Oils and Antimicrobial Activity
- Bacterial biofilms and quorum sensing
- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Bee Products Chemical Analysis
- Infectious Diseases and Tuberculosis
- Antibiotic Resistance in Bacteria
- Phytochemistry Medicinal Plant Applications
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Phytochemicals and Antioxidant Activities
- Probiotics and Fermented Foods
- Acne and Rosacea Treatments and Effects
- Traditional and Medicinal Uses of Annonaceae
- Meat and Animal Product Quality
- Reconstructive Facial Surgery Techniques
- Dermatology and Skin Diseases
- Insect Pest Control Strategies
- Social Issues and Sustainability
- Bacillus and Francisella bacterial research
- Listeria monocytogenes in Food Safety
- Phytochemistry and Biological Activities
- Wound Healing and Treatments
- Nanocomposite Films for Food Packaging
Pinnacle Clinical Research
2023
Mayo Clinic
2019-2021
Mayo Clinic in Arizona
2020-2021
Universidade Estadual Paulista (Unesp)
2015-2020
University of Minnesota Rochester
2020
The antimicrobials products from plants have increased in importance due to the therapeutic potential treatment of infectious diseases. Therefore, we aimed examine chemical characterisation (GC-MS) essential oils (EO) seven and measure antibacterial activities against bacterial strains isolated clinical human specimens (methicillin-resistant Staphylococcus aureus (MRSA) sensitive (MSSA), Escherichia coli, Pseudomonas aeruginosa, Salmonella Typhimurium) foods (Salmonella Enteritidis). Assays...
The in vitro activities of rifampin, rifabutin, rifapentine, and rifaximin were tested against 200 periprosthetic joint infection (PJI)-associated staphylococci. Seven rifampin-resistant isolates had MICs ≥4 μg/ml. Three rifampin 0.25 to 1 μg/ml harbored an Asp471Gly RpoB variant, suggesting that the CLSI rifampin-susceptible staphylococcal breakpoint ≤1 may be too high. remaining ≤0.016 μg/ml, minimum biofilm bactericidal concentrations (MBBC) for ≥50% 8, 1, 2, 4 (for S. aureus) 0.06, 0.25,...
Cefiderocol (CFDC) is a siderophore cephalosporin with activity against Gram-negative bacterial species that are resistant to carbapenems and other drugs. The MICs of CFDC were determined for 610 bacilli, including 302 multinational Enterobacterales isolates characterized mechanisms beta-lactam resistance, 180 clinical from the Mayo Clinic Laboratories not specific resistance mechanisms, 128 ≥8 μg/ml obtained International Health Management Associates, Inc. (IHMA, Schaumburg, IL). Broth...
Owing to patient intolerance or drug interactions, alternative agents rifampin are needed for management of staphylococcal periprosthetic joint infection. In the current study, we evaluated rifabutin, rifapentine and rifampin, with without vancomycin, in a rat model foreign body osteomyelitis.Proximal tibiae were inoculated methicillin-resistant Staphylococcus aureus (MRSA) Kirschner wire (K-wire) implanted each. After 4 weeks infection, administered, alone vancomycin. Tibiae K-wires...
In this study, we aimed to determine whether seasonality affects the content, chemical composition, and antimicrobial activity of essential oils (EOs) from leaves three species Nectandra (Nectandra megapotamica, grandiflora, lanceolata) native Atlantic rainforest, Sao Paulo state, Brazil. addition, identified compounds potentially related activity. Leaves were randomly collected in middle winter (August), spring (November), summer (February), autumn (May). The influence on content...
Consumption of chicken meat and its products, especially sausage, have increased in recent years. However, this product is susceptible to microbial contamination during manufacturing, which compromises shelf life. The flavoring preservative activities essential oils (EO) been recognized the application these antimicrobial agents as natural active compounds food preservation has shown promise. aim study was evaluate effect Ocimum basilicum Origanum vulgare EO on Listeria monocytogenes...
We investigated the responses and mechanisms of action methicillin-resistant Staphylococcus aureus (MRSA) metabolism when exposed under sublethal concentrations synergistic antibacterial combination nisin + oxacillin (¼ maximum concentration) only only. A total 135 proteins were identified, showing an alteration in expression 85 treatment was compared with untreated bacteria (control). When treated using combination, there increase related to resistance (e.g., beta-lactamase) also ones...
Essential oils (EOs) are natural products from plant secondary metabolism. The antibacterial activity of EOs Melaleuca alternifolia, Pelargonium graveolens and Cymbopogon martinii terpinen-4-ol, citronellol geraniol were investigated both in their liquid vapor phases against Gram-positive Gram-negative strains. From microdilution tests, showed a minimal inhibitory concentration (MIC) value 0.05% v/v almost all According to the inverted plate assays, Klebsiella pneumoniae was highly sensitive...
The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on face back, ca. 50% total represented by bacterium Cutibacterium acnes. aim this research was evaluate impact C. martini EO its major compound, geraniol, acnes.The minimum inhibitory concentration against acnes strains, phenotypic changes responses proteome determined. In addition, assessed effect compounds in RNA-binding assay, acnes-exposed...
After staphylococci, streptococci and enterococci are the most frequent causes of periprosthetic joint infection (PJI). MICs minimum biofilm bactericidal concentrations rifampin, rifabutin, rifapentine were determined for 67 enterococcal 59 streptococcal PJI isolates. Eighty-eight isolates had rifampin ≤1 μg/ml, among which rifabutin ≤ 8 ≤4 respectively. There was low rifamycin in vitro antibiofilm activity except a subset Streptococcus mitis group IMPORTANCE Rifampin is an antibiotic with...
Staphylococcus spp. are among the main pathogens responsible for important infections worldwide, both in humans and domestic or wild animals. Chiropterans, popularly known as bats, inhabit natural environments human constructions, have been considered potential disseminators of several pathogens. Studies shown expression mecA gene these animals, being a significant threat to One Health. The objective this study was determine antibiotic resistance presence isolates from bats forest areas...
Arbekacin is a broad-spectrum aminoglycoside with activity against some Gram-positive and Gram-negative bacteria.Arbekacin minimum inhibitory concentration (MIC) values were determined for 296 drug-resistant bacilli, compared to previously plazomicin, amikacin, gentamicin, tobramycin MIC values.The required inhibit 50% 90% of isolates (MIC50 MIC90, respectively) 16 >128 μg/ml, respectively.Arbekacin showed similar MIC50 amikacin lower value than tobramycin, higher plazomicin.
Antibiotic envelopes are being developed for cardiac implantable electronic device (CIED) wrapping to reduce the risk of infections.Fifteen CIED infection-associated bacterial isolates Staphylococcus aureus, epidermidis and Cutibacterium acnes were used assess in vitro biofilm formation on Hylomate® compared titanium, silicone polyurethane coupons pre-treated with vancomycin (400 µg/ml), bacitracin (1000 U/ml) or a combination rifampin (80 µg/ml) plus minocycline (50 µg/ml). Scanning...
Cymbopogon martinii (Roxb.) Wats var. motia essential oil (EO) is usually isolated by steam distillation of the freshly harvested leaves or partially dried [1]. Palmarosa has been widely used in aromatherapy as a tonic skin due its antibacterial, antiviral and anti-inflammatory activity. It also Ayurvedic medicine for problems to relieve pain Propionibacterium acnes microorganism associated with pathogenesis acne; it gram-positive bacteria anaerobic opportunistic [2] an important factor...