A5033089855- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Screening and Detection
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Pain Management
- Appendicitis Diagnosis and Management
- Mycobacterium research and diagnosis
- Pain Management and Opioid Use
- Diverticular Disease and Complications
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Abdominal Surgery and Complications
- Immune cells in cancer
- Brain Metastases and Treatment
- Axon Guidance and Neuronal Signaling
- Asthma and respiratory diseases
- Tuberculosis Research and Epidemiology
- Cancer, Lipids, and Metabolism
Zhejiang Chinese Medical University
2025
Fujian Provincial Hospital
2022-2024
Fujian Medical University
2020-2024
Tongji Hospital
2020-2023
Tongji University
2016-2023
Shanghai Zhabei District Shibei Hospital
2022
East China Normal University
2021-2022
Fujian Provincial People's Hospital
2022
Fujian Provincial Cancer Hospital
2020-2021
Bryan College
2021
Abstract Background Emerging evidences suggest that aberrant metabolites contributes to the immunosuppressive microenvironment leads cancer immune evasion. Among tumor cells, myeloid-derived suppressor cells (MDSCs) are pathologically activated and extremely immunosuppressive, which closely associated with poor clinical outcomes of patients. However, correlation between MDSCs mediated immunosuppression particular metabolism remained elusive. Methods Spontaneous lung adenocarcinoma...
Previous studies have indicated an association between UHR and diabetes risk, but evidence from large-scale diverse populations remains limited. This study aims to verify UHR’s independent role in risk prediction a large sample population assess its applicability across different populations. We drew upon data 30,813 participants collected during the 2005–2018 NHANES cycle. The of was explored using multivariate logistic regression models, with key predictive factors identified through LASSO...
Abstract Background Active myocardial fibrosis plays a pivotal role in valvular heart disease (VHD) progression. While conventional imaging modalities primarily detect established fibrosis, the detection of active fibroblast activation remains challenging. 99 mTc-FAPI SPECT/CT, offering advantages wider availability and lower cost compared to PET imaging, represents promising tool for evaluating fibrosis. Methods We conducted prospective study 30 VHD patients who underwent SPECT/CT with...
Emerging evidence suggests that physiological distress is highly correlated with cancer incidence and mortality. However, the mechanisms underlying psychological challenges-mediated tumor immune evasion are not systematically explored. Here, it demonstrated acute restraint (AR) increases level of plasma neuropeptide hormones, kisspeptin, expression levels its receptor, Gpr54, in hypothalamus, splenic tumor-infiltrating T cells, suggesting a correlation between neuroendocrine system...
Background Gastric cancer is associated with tumor microenvironment and chronic inflammation, but the underlying tumor-promoting mechanisms still remain unknown. Methods The ATAC-seq was used to identify genes chromatin accessibilities in promoter regions. RNA-seq datasets were performed differentially expressed (DEGs). Pearson correlation analysis mRNA expression of three families tumor-related inflammation TFs filter downstream DEGs. Cox univariate survival prognostic value. ImmPort...
Many studies suggest significant genetic variation in the resistance of cattle and humans to infection with Mycobacterium bovis (M. bovis), causative agent zoonotic tuberculosis. TNF-α promotes inflammation induces apoptosis response mycobacterial infection. The aim present study was investigate influence single nucleotide polymorphisms gene on bovine tuberculosis (bTB) susceptibility. We genotyped 74 bTB-infected Holstein cows 90 healthy control animals. exon 3 region bTB susceptibility...
We explored key molecules affecting the prognosis of gastric adenocarcinoma (STAD) using co-analysis chromatin accessibility (ATAC-seq), mRNA expression (RNA-seq), and overall survival.We used assay for transposase-accessible sequencing (ATAC-seq) profiles to identify genes with accessibilities in their promoter regions. The RNA-seq were processed differentially expressed (DEGs) at level. DEGs regions further filtered Pearson correlation TP53 expression. After co-analysis, identified...
Background: Because of the challenge jejunal closure recanalization, uncut Roux-en-Y reconstruction remains controversial. This study aimed to investigate incidence recanalization after in pigs and a small number patients. Methods: Twenty miniature were subjected distal gastrectomy using various rows linear staplers block intestine. The sacrificed, was investigated 1 month operation. From December 2018 June 2019, 10 patients with gastric cancer who had undergone elective laparoscopy-assisted...
G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and play a critical role as pharmacological targets. An improved understanding GPCRs' involvement in tumor microenvironment may provide new perspectives for cancer therapy. This study used machine learning to classify head neck squamous cell carcinoma (HNSCC) patients into two GPCR-based subtypes. Notably, these subtypes showed significant differences prognosis, gene expression, immune microenvironment,...
Cytokine-mediated interactions among the inflammatory cells may play a role in pathogenesis of bronchial asthma. Interleukin-5 (IL-5) is major cytokine recruitment neutrophils to area inflammation. Serum IL-5 marker disease activity and treatment efficacy To understand acute asthma, changes serum concentrations elaborated by activated eosinophil before after prednisolone therapy with clinical improvement were determined present study. Circulating levels 16 normal control subjects sera from...
Many studies suggest significant genetic variation in the resistance of cattle and humans to infection with Mycobacterium bovis, causative agent zoonotic tuberculosis. The inducible nitric oxide synthase (iNOS which is encoded by NOS2 gene) plays a key role immunological control broad spectrum infectious agents. This study aimed investigate influence variations promoter gene on bovine tuberculosis (bTB) susceptibility. In this study, genes 74 bTB-infected Holstein cows 90 healthy controls...
Bridge to elective surgery (BTS) using self-expanding metal stents (SEMSs) is a common alternative emergency (ES) for acute malignant left-sided colonic obstruction (AMLCO). However, studies regarding the long-term impact of BTS are limited and have reported unclear results.A multicenter observational study was performed at three hospitals from April 2012 December 2019. Propensity score matching (PSM) introduced minimize selection bias. The primary endpoint overall survival. secondary...
Abstract Background Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted clarify in the angle circulating tumor cells (CTCs). Methods A multicenter study was performed from March 2018 January 2021. Thirty-two colorectal cancer patients obstruction were selected, which 21 SEMS BTS while 11 emergency surgery. Bloods samples collected two groups for...
Traditional Roux-en-Y may cause stasis syndrome (RSS), and Uncut was proposed to solve this problem. However, because afferent loop recanalization occur after surgery, its clinical application remains controversial. The purpose of study compare the long-term outcomes these two gastrointestinal reconstruction methods. A total 108 patients who received laparoscopic-assisted distal gastrectomy (LADG) were enrolled; 57 randomly divided into (URY) group, 51 (RY) group. Patients followed up for 1...
Sclerosing encapsulating peritonitis (SEP) is a rare cause of intestinal obstruction that characterized by thick greyish-white fibrotic membrane encasing the small bowel. The clinical features are typically nonspecific, and they occasionally present with recurrent episodes incomplete or complete obstruction. etiology SEP remains unclear, diagnosis often delayed mainly due to lack specific symptoms. Here, we first report patient who suffered from after treatment for malignant mesothelioma...
Background Currently, a comprehensive method for exploration of transcriptional regulation has not been well established. We explored novel pipeline to analyze using co-analysis RNA sequencing (RNA-seq), assay transposase-accessible chromatin (ATAC-seq), and immunoprecipitation with high-throughput (ChIP-seq). Methods The G protein-coupled receptors (GPCRs) possibly associated macrophages were further filtered reduced-Cox regression model. ATAC-seq profiles used map the accessibility GPRC5B...
Accumulating evidence suggests that inflammation-related genes may play key roles in tumour immune evasion. Programmed cell death ligand 1 (PD-L1) is an important checkpoint involved mediating anti-tumour immunity. We performed multi-omics analysis to explore affecting the transcriptional regulation of PD-L1 expression. The open chromatin region promoter was mapped using assay for transposase-accessible sequencing (ATAC-seq) profiles. Correlation epigenetic data and transcriptome (RNA-seq)...