A5030757088- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Oral and Maxillofacial Pathology
- Hip and Femur Fractures
- Lipid Membrane Structure and Behavior
- Foot and Ankle Surgery
- Bone fractures and treatments
- RNA Interference and Gene Delivery
- Elbow and Forearm Trauma Treatment
- Bone and Joint Diseases
- Forensic Anthropology and Bioarchaeology Studies
- Musculoskeletal Disorders and Rehabilitation
- Advanced materials and composites
- RNA modifications and cancer
- Photoreceptor and optogenetics research
- Tendon Structure and Treatment
- Pelvic and Acetabular Injuries
- Genetics and Neurodevelopmental Disorders
- Inflammasome and immune disorders
- Molecular Sensors and Ion Detection
University of Ljubljana
2008-2025
Ljubljana University Medical Centre
2015-2025
Zimmer Biomet (United States)
2019
Clinical Orthopaedics and Related Research
2019
GTx (United States)
2018
Institute of Biophysics
2008
The Bernese periacetabular osteotomy is used in dysplastic hips to increase the load-bearing area of hip and prevent osteoarthritis. aim our work was determine contact stress before after compare relief with long-term radiographic clinical outcome.We followed 26 (26 patients) for 7-15 years index operation. Clinical evaluation based on WOMAC score, osteoarthrosis evaluated Tönnis classification, angles lateral (CE) anterior (VCA) femoral coverage were measured, biomechanical parameters...
Hip stresses are generally believed to influence whether a hip develops osteoarthritis (OA); similarly, various osteotomies have been proposed reduce contact and the risk of OA. We asked elevated stress predicted in initially asymptomatic human hips. identified 58 nonoperatively treated nonsubluxated hips with developmental dysplasia (DDH) without symptoms at skeletal maturity; control group included 48 adult disease. The minimum followup was 20 years (mean, 29 years; range, 20-41 years)....
By using a mathematical model of the adult human hip in static one-legged stance position body, forces acting on hip, peak stress joint and other relevant radiographic biomechanical parameters were assessed. The aims to examine if dysplastic hips is higher than normal find out which contribute significantly stress. average normalized (7.1 kPa/N) was markedly (to approximately 100%) (3.5 kPa/N). characteristic that contributed included smaller lateral coverage femoral head, larger interhip...
Undiagnosed low-grade prosthetic joint infections (PJI) are recognized as an important reason for early failure of presumably aseptic revisions. Preoperatively administered antimicrobial prophylaxis reduces the incidence PJI but it may reduce sensitivity microbiologic periprosthetic tissue cultures and consequently increase undiagnosed septic failures, which can lead to catastrophic serial revisions.We wished determine whether administration preoperative antibiotics decreases likelihood...
A simple bone cyst (SBC) is a benign lesion of unknown etiology. It can be differentiated from an aneurysmal (ABC) by radiologic and histopathologic features, as well the absence fusions USP6 gene characteristic ABC. In attempt to differentiate between ABC SBC in recurrent cyst, we performed targeted RNA sequencing found EWSR1-NFATC2 fusion no gene. We subsequently analyzed additional 10 cysts, consistent with SBCs after radiologic-pathologic correlation, for presence NFATC2 fusion,...
Aneurysmal bone cyst (ABC) is a benign but locally aggressive neoplasm, with tendency for local recurrence. In contrast to other tumors secondary cystic change, ABC characterized by USP6 gene rearrangement. There growing list of known fusion partners, characterization which has been enabled the advent next-generation sequencing (NGS). The partners includes CDH11, CNBP, COL1A1, CTNNB1, EIF1, FOSL2, OMD, PAFAH1B1, RUNX2, SEC31A, SPARC, STAT3, THRAP3, and USP9X. Using NGS, we analyzed series 11...
Abstract Background The aim of this nation-wide 2009-2021 cohort study was to analyze postoperative survival patients with resected appendicular skeletal metastases and endoprosthetic reconstruction in comparison sarcoma non-oncological reconstructions. Patients methods A single institution 144 consecutive tumor reconstructions (32 metastases, 73 sarcomas, 39 non-oncological) were stratified into histopathological groups according the 2013-SPRING prediction model. Their analyzed Kaplan-Meier...
Background: Slipping of the capital femoral epiphysis is an important orthopaedic problem early adolescence. Many hypotheses about its etiology have been examined, yet underlying mechanisms not fully elucidated. We examined elevated shear stress in epiphyseal growth plate and contact hip exerted on head as risk factors for slipping epiphysis. Methods: Two groups hips were compared: a group 100 contralateral to slipped ones 70 age- gender-matched healthy hips. The characteristics individual...
Treatment of unicameral bone cysts (UBC) in the humerus with drainage screws is scarcely reported literature. The aim this retrospective study was to compare and alternative treatment methods respect number required surgical procedures achieve sufficient UBC healing, postoperative fractures/recurrences/complications, radiological outcome. Medical archives two tertiary orthopedic referral centers were screened for all patients who treated surgically humeral period 1991–2015 a...
Abstract Background Femoral stems with bimodular (head-neck as well neck-body) junctions were designed to help surgeons address patients’ hip anatomy individually. However, arthroplasty registers have reported higher revision rates in than modularity limited the head-neck trunnion. our knowledge, no epidemiologic study has identified patient-specific risk factors for modular femoral neck fractures, and some using these designs still are produced marketed. Questions/purposes The purposes of...
The NONO gene encodes a nuclear protein involved in transcriptional regulation, RNA synthesis and DNA repair. Hemizygous loss-of function, de novo or maternally inherited variants have been associated with an X-linked syndromic intellectual developmental disorder-34 (OMIM # 300967), characterized by delay, disability, hypotonia, macrocephaly, elongated face, structural abnormalities of corpus callosum and/or cerebellum, congenital heart defect left ventricular non-compaction cardiomyopathy....
Summary Background Osteoid osteomas of the foot are rare, with a varying and atypical clinical as well radiological presentation impeding early diagnosis treatment. The aim present multicentre study was to 1) analyze epidemiological, findings patients osteoid 2) deduce diagnostic algorithm based on findings. Methods A total 37 (25 males, 67.6%, mean age 23.9 years, range 8–57 years) were retrospectively included, treated between 2000 2014 at 6 participating tertiary tumor centres....
The effect of cardiolipin content on the shape and size giant palmitoyloleylphosphatidylcholine/cardiolipin vesicles was studied. Unilamellar were prepared in sugar solution by method electroformation, from mixtures containing up to 50% weight ratio cardiolipin. At room temperature exhibited abrupt changes curvature vesicle contour indicating regions phase separation. deviations spherical larger if made with a higher Numerous soft fluctuating walls observed. estimated found be smaller than...
Background: Minimally invasive distal metatarsal osteotomy (MIDMO) is to be indicated for all patients with angles of IMA <20°and HV <40°, but many authors doubt whether this procedure capable correcting types hallux valgus deformities.The aims study were perform a geometric analysis MIDMO indications and show which preoperative radiological parameters are necessary achieve sufficient contact between bone fragments correction operative technique.Methods: A mathematical model in AP lateral...