A5090023844- Fatty Acid Research and Health
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Diet and metabolism studies
- Ion Transport and Channel Regulation
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Neurogenetic and Muscular Disorders Research
- Fibroblast Growth Factor Research
- Electrolyte and hormonal disorders
- Animal Virus Infections Studies
- Chronic Kidney Disease and Diabetes
- Viral gastroenteritis research and epidemiology
- Metabolism, Diabetes, and Cancer
- Magnesium in Health and Disease
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Lipid Membrane Structure and Behavior
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Connective tissue disorders research
- Blood properties and coagulation
- Metabolism and Genetic Disorders
BioCruces Health research Institute
2020-2023
University of the Basque Country
2021-2023
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2020-2023
Centro de Investigación Biomédica en Red
2023
Instituto de Salud Carlos III
2023
Hospital de Cruces
2020-2022
Centre for Biomedical Network Research on Rare Diseases
2020-2022
Clinica Universidad de Navarra
2004-2005
Complejo Hospitalario Universitario de Santiago
2004-2005
Hospital Universitario La Paz
2005
Obesity is a chronic metabolic disease of high complexity and multifactorial origin. Understanding the effects nutrition on childhood obesity metabolism remains challenge. The aim this study was to determine fatty acid (FA) profile red blood cell (RBC) membranes as comprehensive biomarker children’s metabolism, together with evaluation their dietary intake. An observational carried out 209 children (107 healthy controls, 41 who were overweight 61 obesity) between 6 16 years age. Mature RBC...
Abstract The aim of this study was to estimate the incidence diabetes mellitus in Basque Country and risk factors involved disease by reassessing an adult population after 7 years follow-up. In previous prevalence study, 847 people older than 18 were randomly selected from all over invited answer a medical questionnaire, followed physical examination oral glucose tolerance test. reassessment, same variables collected resulting cohort comprised 517 individuals whom 43 had at baseline....
This work intends to describe the physical properties of red blood cell (RBC) membranes in obese adults. The hypothesis driving this research is that obesity, addition increasing amount body fat, will also modify lipid composition cells other than adipocytes. Forty-nine control volunteers (16 male, 33 female, BMI 21.8 ± 5.6 and 21.5 4.2 kg/m2, respectively) 52 subjects male 36 38.2± 11.0 40.7 8.7 were examined. two techniques applied atomic force microscopy (AFM) spectroscopy mode, which...
The maintenance of magnesium (Mg2+) homeostasis is essential for human life. Cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) have been described to be involved in maintaining Mg2+ homeostasis. Among these CNNMs, CNNM2 expressed the basolateral membrane kidney tubules where it reabsorption. A total four patients, two them with a suspected disorder calcium metabolism, and patients clinical diagnosis primary tubulopathy were screened mutations by...
As the obesity epidemic continues to grow inexorably worldwide, need develop effective strategies prevent and control seems crucial. The use of molecular tools can be useful characterize different phenotypes provide more precise nutritional recommendations. This study aimed determine fatty acid (FA) profile red blood cell (RBC) membranes, together with evaluation their dietary intake biochemical parameters, children adults obesity. An observational was carried out on 196 (113 normal weight...
The GCM2 gene encodes a transcription factor predominantly expressed in parathyroid cells that is known to be critical for development, proliferation and maintenance of the cells. A cohort 127 Spanish patients with disorder calcium metabolism were screened mutations by Next-Generation Sequencing (NGS). targeted panel disorders phosphorus was designed include 65 genes associated these disorders. We observed two variants uncertain significance (p.(Ser487Phe) p.Asn315Asp), one likely pathogenic...
Metabolically healthy obesity (MHO) has been described as BMI ≥ 30 kg/m2, without metabolic disorders traditionally associated with obesity. Beyond this definition, a standardized criterion, for adults and children, not established yet to explain the absence of those disorders. In context, biomarkers inflammation have proposed suitable candidates describe MHO. The use mature red blood cell fatty acid (RBC FA) profile is here since its membrane lipidome includes pro- anti-inflammatory...
Abstract Context Familial neurohypophyseal diabetes insipidus is a rare disease produced by deficiency in the secretion of antidiuretic hormone and caused mutations arginine vasopressin gene. Objective Clinical, biochemical, genetic characterization group patients clinically diagnosed with familial insipidus, 1 largest cohorts protein neurophysin II (AVP-NPII) gene alterations studied so far. Design The AVP-NPII was screened for PCR followed direct Sanger sequencing 15 different unrelated...
Adipokines, as well the fatty acid profile of red blood cell (RBC) membranes, are known to play important roles in development and progression metabolic complications induced by obesity. Thus, objective this study is compare serum adipokine RBC membrane normal-weight obese adults, analyze their relationship with biochemical parameters.An observational case-control was performed 75 adult subjects. Biochemical parameters, eight adipokines profiles were measured. Associations between parameters...
CombiVacS study has demonstrated a strong immune response of the heterologous ChAdOx1-S/BNT162b2 vaccine combination. The primary outcomes were to assess humoral against SARS-CoV-2, 28 days after third dose mRNA vaccine, in subjects that received previous prime-boost scheme with ChAdOx1-S/BNT162b2. Secondary extended 3 and 6 months. mRNA-1273 naive participants previously vaccinated regimen reached higher neutralizing antibodies titers variants concern Delta BA.1 lineage Omicron compared...
Cardiovascular disease is the leading cause of death and disability in Spain. The strategies designed to prevent development such diseases avoid complications patients with HTA include definition simple clinical markers that provide us diagnostic, therapeutic prognostic information. Measurement albuminuria-microalbuminuria heart meets this triple requirement.Recent studies suggest microalbuminuria may be a strong predictor cardiovascular mortality. Moreover, although value 20 mg/min accepted...
Hypertension and microalbuminuria are both cardiovascular (CV) risk factors (RF). Irbesartan reduces blood pressure (BP) albuminuria. The aim of this study was to assess the effects on BP albuminuria 1-year treatment with its translation into CV reduction estimated by specific spanish scores (Framingham-REGICOR) in diabetic non-diabetic patients clinical settings. KORAL-HT is a prospective, open, observational, follow-up hypertensive treated either monotherapy or combination therapy (HCTZ)....
Microalbuminuria is a marker of cardiovascular risk both in hypertensive (HT) and diabetic patients (D). Irbesartan reduces albuminuria type 2 (2DM)subjects. The aim this study was to assess HT with without 2DM evaluate the efficacy reducing BP these clinical settings. KORAL-HT prospective, open, observational 1-year follow-up 1657 H (802 D 855 nonD) who received either monotherapy or combination therapy (HCTZ). At baseline, mean SBP (±SD) [156.4 (±14.1) vs 158.0 (±13.4)] mmHg DBP [91.7...
Abstract Risk stratification for adults infected with SARS-CoV-2 COVID-19 continues to be essential inform decisions about individual patients and allocation of resources treatment options. Accurate knowledge risk severe can make an important contribution healthcare both on a population personal level. There are currently few tools solutions that help medical professionals predict the evolution SARS-COV-2 patients. So far, models outcomes have included age clinical comorbidities. The first...