A5102893407- Respiratory viral infections research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Bacteriophages and microbial interactions
- Dermatology and Skin Diseases
- Congenital Diaphragmatic Hernia Studies
- Respiratory and Cough-Related Research
- Plant Virus Research Studies
- IL-33, ST2, and ILC Pathways
- Mechanical Circulatory Support Devices
- Virus-based gene therapy research
- Allergic Rhinitis and Sensitization
- Calpain Protease Function and Regulation
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Galectins and Cancer Biology
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Bone Metabolism and Diseases
- COVID-19 and healthcare impacts
- Viral Infections and Vectors
- Inhalation and Respiratory Drug Delivery
- Infectious Diseases and Mycology
- Toxoplasma gondii Research Studies
Guangzhou Medical University
2016-2024
Guangzhou Women and Children Medical Center
2020-2024
Southern Medical University
2016-2021
Nanfang Hospital
2016-2021
Weatherford College
2020
Taizhou University
2016
Taizhou Municipal Hospital
2016
Guangdong Province Women and Children Hospital
2015
Capital Medical University
2011
Beijing Children’s Hospital
2006-2011
Our study indicates high efficiency of mNGS using BALF for the detection causative pathogens that cause pneumonia in children. can be a potential diagnostic tool to supplement conventional methods children’s pneumonia.
Abstract To evaluate epidemiology and risk factors of severe adenovirus respiratory infection in hospitalized children Guangzhou, China. A retrospective review study was conducted, 542 for infection, were included from January 2011 to December 2014. Patients younger than 14 years. Disease severity classified into mild. Laboratory tests clinical characteristics analyzed by multivariable logistic regression. Among these children, 92.1% aged < 6 Clinical diagnoses upper infections 11.6%,...
Objective. To examine loss and apoptosis of bronchial epithelial cells in children with asthma. Methods. We examined endobronchial biopsies from 13 asthmatic 11 non-asthmatic control subjects other respiratory diseases. Postmortem samples were obtained six who died non-respiratory shedding by morphology; expression caspase-3 terminal deoxynucleotidyl-mediated dUTP nick end labeling (TUNEL) used to study apoptosis. Results. found be increased compared (p = .001) postmortem .001). Caspase-3+...
Abstract Background Strict countermeasures for coronavirus disease (COVID‐19) were undertaken in China without knowing their influence on asthma. Objective To investigate the associations between frequencies of asthma exacerbations and respiratory infections air pollutants before during COVID‐19 pandemic, which direct consequences pandemic. Methods Asthma among hospitalized children permanent population Guangzhou City, China, from February to June 2016–2019 (before pandemic) 2020 (during...
Abstract Background Talaromyces marneffei ( T. ) is an opportunistic pathogen that infects immunodeficient children. The aim of the study to determine clinical features and peripheral immune state (T. marneffei) infections in children for early detection diagnosis. Methods We retrospectively reviewed 21 pediatric patients who were diagnosed with followed up Guangzhou Women Children’s Medical Center from January 2010 2020. For each patient, we collected analyzed characteristics, immunological...
Respiratory syncytial virus (RSV) infection is the main cause of lower respiratory tract in children. However, there no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers aid Children acute and convalescence phases were recruited proteomic analysis was performed differentially expressed proteins (DEPs). Subsequently, promising candidate determined by functional enrichment protein-protein interaction network analysis, underwent further validation western...
Bronchiolitis obliterans (BO) is an uncommon and severe sequela of chronic obstructive lung disease in children that results from insult to the lower respiratory tract. Few prognostic factors achieved worldwide acknowledgment. In present study, we retrospectively collected with adenoviral infection identified predictive BO. period between Jan 2011 December 2014, consecutive in-hospital acute positive result for adenovirus were enrolled into study. High resolution computerized tomography...
Abstract Self‐assembled virus‐like particles (VLPs) hold great potential as natural nanomaterials for applications in many fields. For such purposes, monodisperse size distribution is a desirable property. However, the VLPs of simian virus 40 (SV40), representative VLP platform, are characterized by polymorphism. In an attempt to eliminate polymorphism, 15 mutants subunit (VP1) constructed through substitution double cysteines at VP1 pentamer interfaces, generating group with altered...
Gu‑Ben‑Fang‑Xiao‑Tang (GBFXT) is a traditional Chinese medicine formula consisting of 11 medicinal plants, which has been used in the treatment asthma. The present study aimed to determine protective effects and underlying mechanisms GBFXT on ovalbumin (OVA)‑induced allergic inflammation mouse model A total 50 mice were randomly assigned following five experimental groups: Normal, model, montelukast (2.6 mg/kg), 12 g/kg 36 groups. Airway responsiveness was measured using forced oscillation...
Lobar pneumonia, one of the community-acquired pneumonia (CAP), is a common pediatric low respiratory tract infection. Calpains are Ca2+-activated cysteine proteases whose activation mechanism elusive. The present study was undertaken to detect role and calpains in lobar pneumonia. human acute lung infection model (ALIM) constructed infected by Streptococcus. Enzyme-linked immunosorbent assay (ELISA) used measure interleukin (IL)-6, IL-8 tumor necrosis factor (TNF)-α. We observed lactate...
X-linked hyper-immunoglobulin M (XHIGM), a primary immunodeficiency syndrome caused by mutations in the CD40 ligand gene(CD40LG), presents with recurrent respiratory infections pediatric patients. We aimed to evaluate spectrum of clinical features and pathogens patients XHIGM China.We retrospectively reviewed seven who were diagnosed received follow-up treatment at Guangzhou Women Children's Medical Center between January 2010 2021. determined their characteristics, causative pathogens,...
Objective It is supposed that bronchial epithelial cells responses to the environmental stimuli are different between asthmatic and non-asthmatic individuals, which contribute pathogenesis of asthma. These produce mediators. If differential gene expressions found in individuals after same vitro, these genes overexpressed children vivo, then it concluded may be associated with Therefore authors analyzed epithelium RSV infection vitro. Among genes, Galectine-7(lectin, galactoside-binding,...
The polymorphism in the self-assembly of capsid protein VP1 simian virus 40 is eliminated through interfacial double-cysteine substitution, resulting homogenous tiny virus-like particles with significantly enhanced structural stability. findings presented by Gen-Quan Yin, Xian-En Zhang, Feng Li, and co-workers article number 2004484 may be instructive for development biosynthetic nanomaterials.
SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed analyze the specific symptoms of Omicron-infected improve patient care.
<title>Abstract</title> Chronic granulomatous disease (CGD) is a lethal immunodeficiency caused by the defective generation of reactive oxygen species phagocyte nicotinamide adenine dinucleotide phosphate (NADPH). It results in recurrent infections catalase-positive bacteria or fungi. Congenital cystic lung rare congenital disease, and compression infection are most common symptoms. Here, we report monochorionic diamniotic twins with X-linked CGD presenting lesions lungs, which were...
Dupilumab inhibiting the signaling of interleukin(IL)-4 and IL-13 was recommended for treatment severe asthma in children ≥ 6 years old according to Global Initiative Asthma (GINA,2024).This study aimed analyse efficacy safety dupilumab paediatric patients with moderate-to-severe comorbid type 2 inflammatory disease a real-world population. We evaluated medical records diseases, such as atopic dermatitis (AD) allergic rhinitis (AR), receiving treatment. Twenty-five (16 boys; mean age, 9.32 ±...
Infantile malignant osteopetrosis (IMO) is a rare autosomal recessive disease characterized by higher bone density in marrow caused the dysfunction of resorption. Clinically, IMO can be diagnosed with medical examination, mineral test and whole genome sequencing.We present case 4-month-old male infant abnormal skull development, hypocalcemia premature closure cranial sutures. Due to hyper showed his radiographic which are characteristic patterns IMO, we speculated that he might an patient....
目的 了解广州市地区住院儿童呼吸道腺病毒感染的临床特点和流行病特征。 方法 收集了2011年1月至2014年12月间小儿呼吸道腺病毒感染的临床资料共544例，并进行了回顾性分析。 结果 临床诊断上呼吸道感染63例(11.6%)，下呼吸道感染481例(88.4%)。在下呼吸道感染里，支气管炎87例(16%)，非重症肺炎336例(61.8%)，重症肺炎58例(10.7%)。混合感染241例，最常见混合病原是肺炎支原体134例(24.6%)。儿童呼吸道腺病毒感染最常见的临床症状是发热94.9%和咳嗽98%。男女感染比是2.7∶1，平均年龄是29月。0～6岁儿童是呼吸道腺病毒感染的好发年龄段(92.1%)。重症肺炎有7例(1.3%)死亡，其中对存活的51例重症腺病毒感染肺炎患儿随访发现17例(27.4%)出现闭塞性细支气管炎，2例(4%)出现支气管扩张，1例(2%)出现肺气肿。 结论 腺病毒感染是引起儿童呼吸道感染的重要病原学，重症腺病毒肺炎导致严重的肺部后遗症。