A5101971370- Bacteriophages and microbial interactions
- Insect Resistance and Genetics
- Bacillus and Francisella bacterial research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Bacterial Genetics and Biotechnology
- Insect and Pesticide Research
- MicroRNA in disease regulation
- Polyomavirus and related diseases
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Cancer-related gene regulation
- Hybrid Renewable Energy Systems
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Electrocatalysts for Energy Conversion
- Clostridium difficile and Clostridium perfringens research
- Organoselenium and organotellurium chemistry
- Hippo pathway signaling and YAP/TAZ
- Probiotics and Fermented Foods
- Selenium in Biological Systems
- Virology and Viral Diseases
- Biochemical and Structural Characterization
Shanghai Jiao Tong University
2022-2024
Hangzhou Normal University
2023-2024
Anhui University of Science and Technology
2024
Wuhan University of Science and Technology
2021-2023
Weatherford College
2023
Wuhan Institute of Virology
2017-2020
Chinese Academy of Sciences
2017-2020
Guangzhou Medical University
2017-2020
National Center for Clinical Laboratories
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Abstract Plant chloroplasts have a highly compartmentalized interior, essential for executing photocatalytic functions. However, the construction of reaction compartment similar to in inorganic–biological hybrid systems (IBS) has not been reported. Drawing inspiration from chloroplast and phenomenon liquid–liquid phase separation, herein, new strategy is first developed constructing subcellular system through separation technology living cells. Photosensitizers vivo expressed hydrogenases...
With the gradual improvement of living standards, incidence gallstones is getting higher and higher, cholesterol (CG) are most prevalent subtype. Therefore, we urgently need a better way to treat gallstones. This study aimed evaluate effects resveratrol (Res) on gallstone formation explore its underlying mechanisms, focusing modulation hepatic peroxisome proliferator-activated receptor γ (PPAR-γ) expression, bile saturation, metabolism. Thirty-two male C57BL/6 mice were randomly divided into...
Molecule encapsulation in virus-based nanoparticles (VNPs) is an emerging bioinspired way to design novel functional nanostructures and devices. Here, we report a general cargo-compatible approach encapsulate guest materials based on the apparent critical assembly concentration (CACapp) of VNPs. Different from conventional buffer-exchange method, new method drives reassembly VNPs cargoes by simply concentrating adequately diluted mixture VNP building blocks above CACapp. This has been proved...
Bacillus thuringiensis is a gram-positive, spore-forming bacterium that forms parasporal crystals at the onset of sporulation phase its growth. Here, we report complete genome sequence B. serovar finitimus strain YBT-020, whose consist Cry26Aa and Cry28Aa crystal proteins are located between exosporium spore coat remain adhering to after sporulation.
We fabricated a novel chitosan-carboxymethyl cellulose (CMC) layer-by-layer assembly system to facilitate the postharvest quality of fresh produce. Fourier transform infrared spectroscopy (FTIR), TA-XT2 texture analyzer, water vapor permeability (WVP) and scanning electron microscopy (SEM) were applied compare properties chitosan assembly. The strategy involved optimization permeability, puncture strength, elasticity multiplayer polymer coating. Results showed that lemon ( Citrus limon (L.)...
Lung adenocarcinoma is a malignant and fatal respiratory disease. However, due to its complex pathogenesis poorly effective therapeutic options, accurate early diagnosis prognosis remain elusive. Now, there increasing evidence that tumor stem cells are involved in tumorigenesis, metastasis, relapse, resistance chemotherapy radiotherapy one of the reasons why tumors cannot be cured. The mRNA expression based-stemness index (mRNAsi) parameter obtained by Malta his colleagues applying...
Crystals in Bacillus thuringiensis are usually formed the mother cell compartment during sporulation and separated from spores after lysis. In a few strains, crystals produced inside exosporium associated with sporulation. This special phenotype, named 'spore crystal association' (SCA), typically occurs B. subsp. finitimus. Our aim was to identify genes determining SCA phenotype finitimus strain YBT-020. Plasmid conjugation experiments indicated that this tightly linked two large plasmids...
Abstract Self‐assembled virus‐like particles (VLPs) hold great potential as natural nanomaterials for applications in many fields. For such purposes, monodisperse size distribution is a desirable property. However, the VLPs of simian virus 40 (SV40), representative VLP platform, are characterized by polymorphism. In an attempt to eliminate polymorphism, 15 mutants subunit (VP1) constructed through substitution double cysteines at VP1 pentamer interfaces, generating group with altered...
HBV-associated hepatitis B virus x protein (HBx) plays multiple roles in the development of hepatocellular carcinoma. In our prior study, we discovered that miR-187-5p expression was inhibited by HBx. To investigate underlying molecular mechanism HBx-mediated downregulation carcinoma cells, effects HBx and on hepatoma cell were observed, as well their interactions. Through vitro vivo experiments, demonstrated overexpression proliferation, migration, invasion. Simultaneously, observed a...
Mpox (MPX) has escalated into a public health emergency of international concern, necessitating urgent prophylactic and therapeutic measures. The primary goal this investigation was to systematically extract Wan Quan’s expertise in treating smallpox, as documented Exclusive Methods for Treating Pox (Dou Zhen Xin Fa Chinese), with the aim identifying potential prescriptions, herbs, components alternative MPX therapies or drugs. This research utilized data mining identify high-frequency...
Full-thickness skin defect has always been a major challenge in clinics due to fibrous hyperplasia the repair process. Hydrogel composite dressings loaded with anti-fibrotic drugs have considered as promising strategy for scarless regeneration. In this work, hydrogel (VP-CMCS-OSA) of carboxymethyl chitosan (CMCS) and oxidized sodium alginate (OSA), loading drug verteporfin (VP), is developed based on two-step chemical reactions. Verteporfin bonded through EDC/NHS treatment form VP-CMCS, then...
The polymorphism in the self-assembly of capsid protein VP1 simian virus 40 is eliminated through interfacial double-cysteine substitution, resulting homogenous tiny virus-like particles with significantly enhanced structural stability. findings presented by Gen-Quan Yin, Xian-En Zhang, Feng Li, and co-workers article number 2004484 may be instructive for development biosynthetic nanomaterials.
Endoscopic nasobiliary drainage (ENBD) and endoscopic retrograde biliary (ERBD) can rapidly alleviate obstruction, facilitate bile drainage, reduce pressure in the duct. In this study, to evaluate effect of plastic stent on recurrence rate choledocholithiasis patients with actual cholangitis after cholangioangiography (ERCP), we a comparative analysis efficacy safety between ENBD ERBD inflammatory remission rate, complication success secondary or multiple lithotomy. A total 347 undergoing...
Chemical doping of boron atoms is essential to modify the electrical properties graphene films. The synthesis large-scale boron-doped with high uniformity and good still a great challenge. To improve quality graphene, we introduced several methods engineer surface copper catalyst for chemical vapor deposition. ethylic acid treatment proved be more effective remove impurities than hydrochloric treatment. Moreover, electrochemical polishing showed best performance in reducing roughness all...
Hepatitis B virus X protein (HBx) is associated with the occurrence and progressive development of hepatitis (HBV)-induced hepatocellular carcinoma (HCC). Usually, microRNAs (miRNAs) participate in regulations on targeting genes carcinogenesis. However, molecular mechanism HBx-induced miRNAs process HCC still undisclosed. This work took an initial step discovering relationship between HBx recent reported miRNAs. Among these miRNAs, decreased regulation miR-187-5p by was observed cell lines....
Background As one of the representative protein materials, nanocages (PNCs) are self‐assembled supramolecular structures with multiple advantages, such as good monodispersity, biocompatibility, structural addressability, and facile production. Precise quantitative functionalization is essential to construction PNCs designed purposes. Results With three modifiable interfaces, interior surface, outer interfaces between building blocks, can serve an ideal platform for precise...