A5022710014- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- Central Venous Catheters and Hemodialysis
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Chronic Kidney Disease and Diabetes
- Hospital Admissions and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
Deutsches Herzzentrum München
2014-2023
Technical University of Munich
2018-2023
Deutsches Herzzentrum der Charité
2021
The role of vascular closure devices (VCD) for the achievement hemostasis in patients undergoing transfemoral coronary angiography remains controversial.To compare outcomes with use 2 strategies after diagnostic performed via access-a VCD-based strategy types devices, an intravascular device and extravascular device, vs standard manual compression. primary hypothesis to be tested was that femoral achieved through VCD is noninferior compression terms access-site complications. A secondary...
The efficacy and safety of a reduced dose prasugrel versus standard ticagrelor in elderly patients or those with low body weight presenting an acute coronary syndrome (ACS) are unknown.To investigate the effect age- weight-adapted ACS. (ClinicalTrials.gov: NCT01944800).Prespecified analysis multicenter, randomized ISAR-REACT 5 trial.23 centers Germany Italy.3997 ACS planned for invasive management.Participants were randomly assigned to receive (reduced low-weight group neither nor group).The...
The aim of this study was to assess the efficacy and safety ticagrelor versus prasugrel in patients with diabetes mellitus (DM) presenting acute coronary syndromes (ACS) whom invasive therapy planned. ACS DM undergoing treatment remain unknown. This pre-specified analysis ISAR-REACT (Intracoronary Stenting Antithrombotic Regimen: Rapid Early Action for Coronary Treatment) 5 trial included 892 3,124 without randomized or ticagrelor. primary endpoint a composite death, myocardial infarction,...
It is unclear whether ticagrelor or prasugrel hydrochloride superior for patients with acute coronary syndrome (ACS) treated percutaneous intervention (PCI).To assess the safety and efficacy of vs ACS PCI.A prespecified analysis was performed a postrandomization subgroup 3377 who presented were PCI in investigator-initiated, multicenter, phase 4, open-label Intracoronary Stenting Antithrombotic Regimen: Rapid Early Action Coronary Treatment 5 randomized clinical trial, conducted from...
The value of vascular closure devices (VCD) in women undergoing transfemoral catheterization has not been sufficiently investigated.This is a sex-specific analysis 1395 enrolled large-scale, randomized, multicenter trial, which patients diagnostic coronary angiography were randomly assigned 1:1:1 ratio to arteriotomy with an intravascular VCD, extravascular or manual compression (MC). Primary objective was assess the safety and efficacy 2 different VCD compared MC regarding access-site...
Abstract Aims To define the incidence of events related to stented vessel (target events: TVRE) and non-stented vessels (non-target NTVRE) through 10-year follow-up in patients post-PCI with newer generation drug eluting stents (DES). Methods results The current study is a post-hoc analysis patient level data from two randomised controlled trials Germany. Patients older than 18 years ischemic symptoms or evidence myocardial ischemia presence ≥ 50% de novo stenosis located native coronary...
Vascular closure devices (VCD) have been introduced into clinical practice with the aim of increasing procedural efficiency and safety coronary angiography. However, studies comparing VCD manual compression yielded mixed results, large randomised trials two strategies are missing. Moreover, comparative efficacy between different in routine use lacking.The Instrumental Sealing ARterial puncture site - CLOSURE device versus (ISAR-CLOSURE) trial is a prospective, designed to compare outcomes...
Abstract Aims Aim of the present study was to investigate impact increasing neointimal inhomogeneity and neoatherosclerosis as well treatment modality in-stent restenosis (ISR) on occurrence periprocedural myocardial injury (PMI). Methods results Patients with normal or stable/falling increased baseline high-sensitivity troponin T (hs-cTnT) undergoing intravascular optical coherence tomography (OCT) subsequent percutaneous coronary intervention (PCI) ISR by means drug-coated balloon (DCB)...
Sex-specific analyses of direct head-to-head comparisons between newer P2Y
The aim of this study was to assess the association between high on-aspirin treatment platelet reactivity (HAPR) and subsequent risk restenosis after percutaneous coronary intervention (PCI) with predominantly drug-eluting stents.
To assess the efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndrome (ACS) presenting during off- on-hours.The ACS according to time hospital presentation remain unknown.This post hoc analysis ISAR-REACT 5 trial included 1565 off-hours 2453 on-hours, randomized or prasugrel. The primary endpoint was a composite death, myocardial infarction, stroke; Bleeding Academic Research Consortium (BARC) type 3-5 bleeding, both at 12 months.The occurred 80 (10.4%)...
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To assess whether the efficacy and safety of ticagrelor vs. prasugrel in patients with acute coronary syndromes (ACSs) are influenced by pre-admission treatment aspirin and/or clopidogrel. Patients (n = 4018) were categorized into two groups: clopidogrel group 1455) no or 2563). The primary endpoint was composite all-cause death, myocardial infarction, stroke; secondary Bleeding Academic Research Consortium (BARC) type 3-5 bleeding, both at 1 year. had a higher risk ischaemic events, but...
BACKGROUND Whether there are differences in the risk profile and treatment effect patients recruited a low recruitment center (LRC) versus high (HRC) randomized multicenter trial remains unknown. METHODS AND RESULTS This study included 4018 with acute coronary syndrome ISAR-REACT 5 (Intracoronary Stenting Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5) trial. The primary end point was composite of all-cause death, myocardial infarction, or stroke. Overall, 3011 (75%)...
Fazit Der Einsatz von Gefäßpunktionsverschluss-Systemen bei Patienten nach Koronarangiografie ist der manuellen Kompression hinsichtlich zugangsbedingter Komplikationen und Zeit bis zur Hämostase nicht unterlegen.
Abstract Objectives To investigate the efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndrome (ACS) prior myocardial infarction (MI). Background The ACS MI remains unstudied. Methods Patients scheduled for an invasive strategy randomized to or ISAR-REACT 5 trial available information concerning were included present analysis. primary endpoint was composite all-cause death, infarction, stroke; secondary Bleeding Academic Research Consortium (BARC) type 3...