A5038655641- Glycosylation and Glycoproteins Research
- Advanced Proteomics Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- SARS-CoV-2 detection and testing
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Respiratory viral infections research
- Advanced biosensing and bioanalysis techniques
- Plant Virus Research Studies
- Protein purification and stability
- Gene expression and cancer classification
- Mass Spectrometry Techniques and Applications
- Animal Disease Management and Epidemiology
- Chemical Synthesis and Analysis
- Anodic Oxide Films and Nanostructures
- Nanopore and Nanochannel Transport Studies
- Cancer-related molecular mechanisms research
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Microbial Community Ecology and Physiology
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
Robert Koch Institute
2022-2025
German Research Centre for Artificial Intelligence
2024
Institute for Regional Studies
2022
Abstract Monoclonal antibodies are biotechnologically produced proteins with various applications in research, therapeutics and diagnostics. Their ability to recognize bind specific molecule structures makes them essential research tools therapeutic agents. Sequence information of is helpful for understanding antibody–antigen interactions ensuring their affinity specificity. De novo protein sequencing based on mass spectrometry a valuable method obtain the amino acid sequence peptides...
Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within environments. By directly analyzing metaproteomics offers phenotypes roles individual members play in diverse ecosystems. Although database-dependent search engines are commonly used for peptide identification, they rely on pre-existing protein databases, which can be limiting complex, poorly...
Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within environments. By directly analyzing metaproteomics offers on phenotypes roles individual members play in diverse ecosystems. While database-dependent search engines are commonly used for peptide identification, they rely pre-existing protein databases, which can be limiting complex, poorly...
During the mpox outbreak in 2022, highest number of cases Germany were registered Berlin, almost all them men who have sex with (MSM). However, frequency clinically undiagnosed infections is unknown.
ABSTRACTGlobal and even national genome surveillance approaches do not provide the resolution necessary for rapid accurate direct response by local public health authorities. Hence, a regional network of microbiological laboratories in collaboration with departments all districts German federal state Mecklenburg-Western Pomerania (M-V) was formed to investigate molecular epidemiology circulating SARS-CoV-2 lineages between 11/2020 03/2022. More than 4750 samples from M-V counties were...
During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines importance of as universal bioanalytical reagents. However, little attention is given to reproducibility crisis that scientific studies are still facing date. In a recent study, not even half all research mentioned in publications could be identified at all. should spark more efforts search practical solutions traceability antibodies. For this...
The International Virus Bioinformatics Meeting 2022 took place online, on 23-25 March 2022, and has attracted about 380 participants from all over the world. goal of meeting was to provide a meaningful interactive scientific environment promote discussion collaboration inspire suggest new research directions questions. created highly even without physical face-to-face interactions. This is focal point gain an insight into state-of-the-art virus bioinformatics landscape interact with...
During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines importance of as universal bioanalytical reagents. However, little attention is given to reproducibility crisis that scientific studies are still facing date. In a recent study, not even half all research mentioned in publications could be identified at all. should spark more efforts search practical solutions traceability antibodies. For this...
<title>Abstract</title> With case numbers exceeding 97,000 worldwide, the 2022 global mpox outbreak underscored potential for zoonotic diseases with limited human-to-human transmission to trigger a widespread health crisis. Primarily men who have sex (MSM) were affected. Monitoring mpox-specific seroprevalences through epidemiological studies is essential, but challenging due cross-reactive antibody immune response which induced by several orthopoxviruses including modified vaccinia virus...
Motivation Nanopore sequencing represents a significant advancement in genomics, enabling direct long-read DNA at the single-molecule level. Accurate simulation of nanopore signals from nucleotide sequences is crucial for method development and complementing experimental data. Most existing approaches rely on predefined statistical models, which may not adequately capture properties signal Furthermore, these simulators were developed earlier versions chemistry, limits their applicability...
Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within environments. By directly analyzing metaproteomics offers on phenotypes roles individual members play in diverse ecosystems. While database-dependent search engines are commonly used for peptide identification, they rely pre-existing protein databases, which can be limiting complex, poorly...
Nanopore sequencing represents a significant advancement in genomics, enabling direct long-read DNA at the single-molecule level. Accurate simulation of nanopore signals from nucleotide sequences is crucial for method development and complementing experimental data. Most existing approaches rely on predefined statistical models, which may not adequately capture properties signal Furthermore, these simulators were developed earlier versions chemistry, limits their applicability adaptability...
Abstract Monoclonal antibodies (mAbs) are biotechnologically produced proteins with various applications in research, therapeutics, and diagnostics. Their ability to recognize bind specific molecule structures makes them essential research tools therapeutic agents. Sequence information of is helpful for understanding antibody-antigen interactions ensuring their affinity specificity. De novo protein sequencing based on mass spectrometry a useful method obtain the amino acid sequence peptides...