A5009875007- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Fire effects on ecosystems
- Viral Infections and Outbreaks Research
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Energy and Environment Impacts
- Livestock and Poultry Management
- Antibiotic Resistance in Bacteria
- Plant Virus Research Studies
- Vector-borne infectious diseases
- Virology and Viral Diseases
- Genomics and Phylogenetic Studies
- Helicobacter pylori-related gastroenterology studies
- Biosensors and Analytical Detection
- Postharvest Quality and Shelf Life Management
- Hepatitis B Virus Studies
- Genetic diversity and population structure
- T-cell and Retrovirus Studies
- Genetic and phenotypic traits in livestock
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
International Livestock Research Institute
2019-2025
South African National Biodiversity Institute
2022-2023
University of the Western Cape
2022-2023
Rift Valley fever (RVF), a mosquito-borne transboundary zoonosis, was first confirmed in Rwanda's livestock 2012 and since then sporadic cases have been reported almost every year. In 2018, the country experienced its large outbreak, which followed by second one 2022. To determine circulating virus lineages their ancestral origin, two genome sequences from 2018 thirty-six, forty-one, thirty-eight of small (S), medium (M), (L) segments, respectively, 2022 outbreak were generated. All samples...
Abstract Introduction Recent Rift Valley fever (RVF) epidemiology in eastern Africa region is characterized by widening geographic range and increasing frequency of small disease clusters. Here we conducted studies southwestern (SW) Uganda that has since 2016 reported RVF activities. Methods A 22-month long hospital-based study three districts SW targeting patients with acute febrile illness (AFI) or unexplained bleeding was followed a cross-sectional population-based human-animal survey. We...
Inter-individual variability in the microbial gene complement encoding for carbohydrate-active enzymes (CAZymes) can profoundly regulate how host interacts with diverse carbohydrate sources thereby influencing health. CAZy-typing, characterizing microbiota-associated CAZyme-coding genes within a individual, be useful tool to predict pools that metabolize, or identify which CAZyme families are underrepresented requiring supplementation via microbiota transplantation probiotics. moreover,...
Genetic evolution of Rift Valley fever virus (RVFV) in Africa has been shaped mainly by environmental changes such as abnormal rainfall patterns and climate change that occurred over the last few decades. These gradual are believed to have effected gene migration from macro (geographical) micro (reassortment) levels. Presently, 15 lineages RVFV identified be circulating within Sub-Saharan Africa. International trade livestock movement mosquitoes thought responsible for outbreaks occurring...
One of the crucial public health problems today is emerging and re-emerging multidrug-resistant (MDR) bacteria coupled with a decline in development new antimicrobials. Non-typhoidal Salmonella (NTS) classified among MDR pathogens international concern. To predict their potentials, 23 assembled genomes NTS from live cattle (n = 1), beef carcass 19), butchers’ hands 1) processing environments 2) isolated 830 wet swabs at Yaounde abattoir between December 2014 November 2015 were explored using...
Rift Valley fever (RVF) is a febrile vector-borne disease endemic in Africa and continues to spread new territories. It climate-sensitive mostly triggered by abnormal rainfall patterns. The associated with high mortality morbidity both humans livestock. RVF caused the virus (RVFV) of genus Phlebovirus family Phenuiviridae. tripartite RNA three genomic segments: small (S), medium (M) large (L). Pathogen sequencing becoming routine procedure powerful tool for understanding evolutionary...
African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100% mortality rates caused by the ASF virus (ASFV). The locally-adapted South-western Kenya have been reported be resilient and harsh climatic conditions tolerate ASF; however, mechanisms which this tolerance sustained remain largely unknown. We evaluated gene expression patterns spleen tissues of these response varying infective doses ASFV elucidate virus-host interaction dynamics.Locally...
Previous studies in the Central African Republic (CAR) have reported presence of hepatitis B virus (HBV) recombinant genotype E/D and a suspicion immune escape mutants (IEMs), without further investigation into their impact on prevention diagnosis. Consequently, this study investigated HBV mutations among surface antigen (HBsAg)-positive patients attending Institut Pasteur de Bangui CAR.Sera from total 118 HBsAg-positive with no previous history treatment or vaccination at Bangui, were...
Banana is a climacteric fruit whose ripening once initiated irreversible and proceeds very fast making the fruits highly perishable. Application of various post-harvest technologies has been shown to slow down process in such as banana. One these hexanal, naturally occurring compound that delays banana without compromising quality. As molecular mechanisms underlying mode action hexanal delaying are yet be elucidated, we undertook comparative transcriptomic analysis using treated with either...
Theileria parva is a protozoan parasite that causes East Coast fever (ECF), an economically important disease of cattle in Africa. It transmitted mainly by the tick Rhipicephalus appendiculatus. Research efforts to develop subunit vaccine based on neutralizing antibodies and cytotoxic T-lymphocytes have met with limited success. The molecular mechanisms underlying T. life cycle stages vector bovine host are poorly understood, thus limiting progress toward effective efficient control ECF....
The International Virus Bioinformatics Meeting 2022 took place online, on 23-25 March 2022, and has attracted about 380 participants from all over the world. goal of meeting was to provide a meaningful interactive scientific environment promote discussion collaboration inspire suggest new research directions questions. created highly even without physical face-to-face interactions. This is focal point gain an insight into state-of-the-art virus bioinformatics landscape interact with...
Abstract Rift Valley fever virus (RVFV) is a mosquito-borne RNA of the Phlebovirus genus in phenuviridae family. Its genome trisegmented with small (S), medium (M) and large (L) fragments. In nature, exists as single serotype that responsible for outbreaks (RVF), zoonotic disease often occurs Africa Middle East. RVFV genomes are thought to undergo both recombination reassortment investigations these events important monitoring emergence virulent strains understanding evolutionary...
Newcastle disease (ND) control by vaccination and an institution of biosecurity measures is less feasible in backyard chicken developing countries. Therefore, alternative strategy like the genetic selection susceptible genotypes a promising option. In present study, polymorphism LEIO258 marker association with susceptibility to virulent virus (NDV) infection Kuroilers, Sasso, local Tanzanian embryos were investigated. Samples from high (15%) cohorts genotyped sequencing LEI0258 marker. A...
Context Chickens are the most important livestock in Democratic Republic of Congo particular and Africa general; they kept for their meat eggs nutrition economic status. The availability chicken diversity information is very selection breeds conservation genetic resources. Aims This study aimed to determine allelic variability, diversity, relationships indigenous populations from South Kivu region support breeding programs resource conservations. Methods LEI0258 microsatellite marker within...
Abstract Wastewater-based surveillance (WBS) has become a useful public health tool as an early warning system revealing emergence/re-emergence of pathogenic diseases and spread antimicrobial resistance (AMR). WBS is crucial in development rapid response increasing awareness to curb dangers associated with disease emergence antibiotic resistance. In this study, we characterized bacterial pathogens detected wastewater, their composition, relative abundance resistant genes (ARGs) from...
Abstract The evolutionary history of Rift Valley fever virus (RVFV) is complex and has been greatly influenced by dramatic environmental changes throughout Africa in the past few decades. Over this time period, RVFV gene flow impacted on various levels such as geographic dispersal reassortment events. Overall, there are 15 lineages, designated from A to O. In many cases, viruses these lineages have detected outside enzootic regions through probable movement infected animals and/or...