A5076526853- Parasites and Host Interactions
- Zoonotic diseases and public health
- HIV, Drug Use, Sexual Risk
- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Global Maternal and Child Health
- Genetics, Aging, and Longevity in Model Organisms
- Opioid Use Disorder Treatment
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Photoreceptor and optogenetics research
- Zebrafish Biomedical Research Applications
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Neurogenesis and neuroplasticity mechanisms
- Bacterial Genetics and Biotechnology
- Child Nutrition and Water Access
- Physiological and biochemical adaptations
- Autism Spectrum Disorder Research
- Cardiac Fibrosis and Remodeling
- Lipid Membrane Structure and Behavior
- Urological Disorders and Treatments
- Pain Management and Opioid Use
- Homelessness and Social Issues
University of Glasgow
2020-2025
Fox Chase Cancer Center
2024
Open Data Institute
2023
University of Oxford
2021-2023
Temple University
2023
Wellcome Centre for Molecular Parasitology
2021-2022
Département Santé Animale
2020-2022
University of Edinburgh
2017-2020
University of Surrey
2020
UNSW Sydney
2018-2019
The specificity of 26 monoclonal antibodies against the CA 125 antigen was investigated in two phases ISOBM TD-1 workshop. binding studied using immunoextracted by specific immobilized on various solid phases, or surface human cell lines. Immunometric assays all possible antibody combinations were used to study topography sites antigen. We conclude that carries only major antigenic domains, which classifies as OC125-like (group A) M11-like B). One antibody, OV 197, showed related some...
Schistosomiasis is a parasitic disease acquired through contact with contaminated freshwater. The definitive hosts are terrestrial mammals, including humans, some Schistosoma species crossing the animal-human boundary zoonotic transmission. An estimated 12 million people live at risk of schistosomiasis caused by japonicum and mekongi , largely in World Health Organization’s Western Pacific Region Indonesia. Mathematical models have played vital role our understanding biology, transmission,...
Abstract Background The Global Programme to Eliminate Lymphatic Filariasis (GPELF) aims reduce and maintain infection levels through mass drug administration (MDA), but there is evidence of ongoing transmission after MDA in areas where Culex mosquitoes are the main vector, suggesting that a more stringent criterion required for decision making these settings. Methods We use model investigate how lower prevalence threshold (<1% antigenemia [Ag] compared with <2% Ag prevalence)...
OBJECTIVES: This paper provides 1996 information on the status of US syringe exchange programs and compares these findings with data from our 1994 survey. METHODS: In November 1996, questionnaires were mailed to 101 programs. Program directors contacted conduct telephone interviews based questionnaires. Data collected included number syringes exchanged, program operations, legal status, services offered. RESULTS: Eighty-seven participated in A total 46 (53%) legal, 20 (23%) illegal but...
Abstract Fundamental ecological processes, such as extrinsic mortality, determine population age structure. This influences disease spread when individuals of different ages differ in susceptibility or maternal determines offspring susceptibility. We show that Daphnia magna born to young mothers are more susceptible than those older mothers, and consider this alongside previous observations declines with system. used a susceptible‐infected compartmental model investigate how age‐specific...
Abstract Diagnostics for COVID-19 detection are limited in many settings. Syndromic surveillance is often the only means to identify cases but lacks specificity. Rapid antigen testing inexpensive and easy-to-deploy can lack sensitivity. We examine how combining these approaches improve guiding interventions low-income communities Dhaka, Bangladesh. Rapid-antigen-testing with PCR validation was performed on 1172 symptomatically-identified individuals their homes. Statistical models were...
The hippocampus arises from the medial region of subventricular (SVZ) within telencephalon. It is one two regions in postnatal brain that harbors neural progenitors (NPs) capable giving rise to new neurons. Neurogenesis restricted subgranular zone (SGZ) dentate gyrus (DG) where it contributes generation granule cell layer (gcl) thought SGZ are heterogeneous, differing their morphology, expression profiles, and developmental potential, however currently unknown whether they display...
Summary The bacterial flagellar motor powers the rotation that propels swimming bacteria. Rotational torque is generated by harnessing flow of ions through ion channels known as stators which couple energy from gradient across inner membrane to rotor. Here, we used error‐prone PCR introduce single point mutations into sodium‐powered Vibrio alginolyticus / Escherichia coli chimeric stator PotB and selected for motors exhibited motility in presence sodium‐channel inhibitor phenamil. We found...
Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11 ALL1 fused from 1q (MLLT11/AF1q) is a highly conserved 90 amino acid protein that functions in hematopoietic differentiation. Its translocation the Trithorax locus has been implicated malignancies of system. However, spatio-temporal profile MLLT11 expression during embryonic development not characterized. Here we show remarkably specific pattern developing central and peripheral nervous We find high levels transcript...
Despite decades of interventions, 240 million people have schistosomiasis. Infections cannot be directly observed, and egg-based Kato-Katz thick smears lack sensitivity, affected treatment efficacy reinfection rate estimates. The point-of-care circulating cathodic antigen (referred to from here as POC-CCA+) test is advocated an improvement on the method, but improved estimates are limited by ambiguities in interpretation trace results.We collected repeated egg counts 210 school-aged children...
<ns3:p>The World Health Organization recently launched its 2021-2030 roadmap, <ns3:italic>Ending</ns3:italic><ns3:italic> the </ns3:italic><ns3:italic>Neglect</ns3:italic><ns3:italic> to </ns3:italic><ns3:italic>Attain</ns3:italic><ns3:italic> </ns3:italic><ns3:italic>Sustainable Development Goals</ns3:italic><ns3:italic>,</ns3:italic> an updated call arms end suffering caused by neglected tropical diseases. Modelling and quantitative analyses played a significant role in forming these...
AbstractReproduction, mortality, and immune function often change with age but do not invariably deteriorate. Across the tree of life, there is extensive variation in age-specific performance changes to key life-history traits. These occur on a spectrum from classic senescence, where declines age, juvenescence, improves age. Reproduction, are also important factors influencing spread infectious disease, yet exists no comprehensive investigation into how aging these traits impacts epidemics....
Schistosomiasis is a parasitic disease affecting over 240-million people. World Health Organization (WHO) targets for Schistosoma mansoni elimination are based on Kato-Katz egg counts, without translation to the widely used, urine-based, point-of-care circulating cathodic antigen diagnostic (POC-CCA). We aimed standardize POC-CCA score interpretation and translate them Kato-Katz-based standards, broadening utility in progress towards elimination. A Bayesian latent-class model was fit data...
Abstract Caloric restriction (CR) produces clear phenotypic effects within and between generations of the model crustacean Daphnia magna . We have previously established that micro‐RNAs cytosine methylation change in response to CR this organism, we demonstrate here has a dramatic effect on gene expression. Over 6,000 genes were differentially expressed well‐fed D. , with bias towards up‐regulation under caloric restriction. identified highly haemoglobin responds by changing isoform...
Neglected tropical diseases (NTDs) largely impact marginalised communities living in and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it known that there lack of access to treatment some populations demographic groups. It also likely those individuals without are excluded from surveillance. important consider impacts this on overall success, monitoring evaluation (M&E) programmes. We use a detailed individual-based model...