A5035375992- MicroRNA in disease regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Renal Transplantation Outcomes and Treatments
- Cancer-related gene regulation
- Phytochemical Studies and Bioactivities
- Kruppel-like factors research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- 14-3-3 protein interactions
- Extracellular vesicles in disease
- Nematode management and characterization studies
- Ferroptosis and cancer prognosis
- Soybean genetics and cultivation
- Lipid metabolism and biosynthesis
- Inflammatory Biomarkers in Disease Prognosis
- Transplantation: Methods and Outcomes
- Hernia repair and management
University of Science and Technology Beijing
2025
Yangtze University
2025
Fudan University
2016-2023
Minhang District Central Hospital
2016-2023
Zhongshan Hospital
2018-2021
Sun Yat-sen University
2018-2021
The First Affiliated Hospital, Sun Yat-sen University
2018-2021
Shanghai Jiao Tong University
2007-2008
Ruijin Hospital
2007-2008
Cultured human umbilical cord mesenchymal stem cells (hUC-MSCs) are being tested in several clinical trials and encouraging outcomes have been observed. To determine whether vitro expansion influences the genomic stability of hUC-MSCs, we maintained nine hUC-MSC clones long-term culture comparatively analyzed them at early late passages. All senesced culture, exhibiting decreased telomerase activity shortened telomeres. Two showed no DNA copy number variations (CNVs) passage 30 (P30). Seven...
Abstract Objectives Circular RNAs (circRNAs) are RNA transcripts that belong to non‐coding (ncRNAs), whose implication in human cancers has been recently demonstrated. However, the specific role of multiple circRNAs breast cancer remains unidentified. Materials and methods Microarray analysis bioinformatics were applied select circRNA miRNA, respectively. The loop structure circ‐TFF1 was confirmed using RNase R treatment, divergent primer PCR Sanger sequencing. qRT‐PCR Western blot employed...
Cytotoxic chemotherapy is the major strategy to prevent and reduce triple-negative breast cancer (TNBC) progression metastasis. Hypoxia increases chemoresistance associated with a poor prognosis for patients cancer. Based on accumulating evidence, microRNAs (miRNAs) play an important role in acquired drug resistance. However, of miRNAs hypoxia-induced TNBC resistance remains be clarified. Here, we found that hypoxia induced docetaxel by decreasing miR-494 level. Modulating expression altered...
Abstract Krüppel‐like transcription factor (KLF) family is involved in tumorigenesis different types of cancer. However, the importance KLF gastric cancer unclear. Here, we examined gene expression five paired liver metastases and primary tissues by RT‐PCR, immunohistochemistry was used to study KLF8 206 samples. The impact on glycolysis, an altered energy metabolism that characterizes cells, evaluated. showed highest up‐regulation compared with tumours among all members. Higher associated...
The thermoelectric performance of n-type Bi2Te3-based material is generally poorer than that p-type material. By combining density functional theory (DFT) calculations with experimental characterization, the mechanisms difference between and hot-extruded materials were clarified, strategies to improve their properties further proposed. One primary reasons for associated its high intrinsic carrier concentration due higher effective mass, which results in lower Seebeck coefficient thermal...
Introduction Branches are important for soybean yield, and previous studies examining branch traits have primarily focused on number (BN), while research assessing internode (BIN), length (BL), (BIL) remains insufficient. Methods A recombinant inbred line (RIL) population consisting of 364 lines was constructed by crossing ZD41 ZYD02878. Based the RIL population, we genetically analyzed four using different GWAS methods including efficient mixed-model association expedited, restricted...
DCAF13 is firstly identified as a substrate receptor of CUL4-DDB1 E3 ligase complex. This study disclosed that acted novel RNA binding protein (RBP) contributed to triple-negative breast cancer (TNBC) metastasis. Clinical data obtained from TCGA and our collection showed was closely correlated with poor clinicopathological characteristics overall survival, which indicated may serve diagnostic marker for TNBC Functionally, overexpression or suppression sufficient enhance decrease cell...
Circular RNAs (circRNAs) play an extremely important regulatory role in the occurrence and development of various malignant tumors including papillary thyroid cancer (PTC). circFAT1(e2) is a new type circRNA derived from exon 2 FAT1 gene, which distributed cytoplasm nucleus PTC cells. However, so far, still unclear. In this study, was found to be highly expressed cell lines tissues. knockdown suppressed growth, migration, invasion. Also, acted as sponge for potential microRNAs (miRNAs)...
Mycophenolate mofetil (MMF) is a very powerful immunosuppressive drug used in preventing acute rejection liver transplantation. However, MMF has some serious side effects, including hematologic and gastrointestinal disorders. This study was designed to investigate the relationship between clinical events pharmacokinetics of mycophenolic acid (MPA) Chinese transplant recipients. Sixty-three adult recipients receiving 1.0 g twice daily combination with tacrolimus were prospectively included....
Development of docetaxel (TXT) resistance is a major obstacle for triple-negative breast cancer (TNBC) treatment. Additionally, chemoresistant cell-derived exosomes were able to change the chemo-response chemosensitive recipient cells via transportation lncRNAs. It has been shown that lncRNA LINC00667 level was significantly elevated in tissues. Therefore, we explored whether increased TXT-resistant TNBC exosomes. In addition, exosomal derived from cell could affect TXT sensitivity...
Mycophenolate mofetil (MMF) is indicated as immunosuppressive therapy in liver transplantation. The abbreviated models for the estimation of mycophenolic acid (MPA) area under concentration-time curve (AUC) have been established by limited sampling strategies (LSSs) adult transplant recipients. In current study, performance to predict MPA exposure was validated an independent group patients. A total 30 pharmacokinetic profiles from recipients receiving MMF combination with tacrolimus were...
Liver cancer is the second most frequent cause of death in men and sixth leading women. Hepatocellular carcinoma (HCC) represents major subtype liver its five-year survival rate remains very poor. Sorafenib, a molecular targeted therapeutic agent, was first drug approved for treatment patients with HCC. However, clinical response sorafenib seriously limited by resistance. Autophagy an evolutionarily conserved mechanism among all eukaryotes. Recently, many studies have indicated that...
Background: Krüppel-like transcription factor (KLF) family is involved in tumorigenesis different types of cancer. However, the importance KLF gastric cancer not fully investigated. Methods: We first screened out target gene by RT-PCR analysis glucose metabolism related genes five liver metastases and their primary tissues, then immunohistochemistry was used to study KLF8 protein expression 206 samples. The impact on growth glycolysis were studied using vitro as well patients' Results: most...
Abstract The conjecture of breast cancer is uncertain because its explosive growth and the complicated molecular mechanisms. Circular RNAs (circRNAs) are regulatory RNA sequences present in genome their mechanism involves sponging microRNAs (miRNAs). In this study, we explored regulation between circular forms dedicator cytokinesis 1 (circDOCK1) (hsa_circ_0007142) miR‐128‐3p, implication on pathogenesis modulated by never mitosis (NIMA) related kinase 2 (NEK2). We revealed an increase...
Thyroid cancer (TC) is a kind of with high heterogeneity, which leads to significant difference in prognosis. The prognostic molecular processes are not well understood. Cancer cells and tumor microenvironment (TME) jointly determine the heterogeneity. However, quite little attention was paid TME past years. In this study, we only reveal that endothelial (ECs) strongly associated progress papillary thyroid (PTC) using single-cell RNA-seq (scRNA-seq) data downloaded from Gene Expression...
Abstract Polyphyllin D (PD), one of the important steroid saponins in traditional medicinal herb Paris polyphylla , has been demonstrated to have anticancer activity both vitro and vivo. However, mechanisms through which PD exerts its effects triple-negative breast cancer (TNBC) remain unclear. Our study was presented evaluate effect potential two TNBC cell lines, BT-549 MDA-MB-231. Through comprehensively comparing liquid chromatography-tandem mass spectrometry (LC–MS/MS) data PD-treated...
Objective To observe the effect of indomethacin on immune function and coagulation patients with metastatic breast cancer. Methods Totally 27 cancer in Department Breast Surgery, Minhang Branch, Zhongshan Hospital, Fudan University from July 2015 to December 2017 were enrolled this prospective study. They treated at dosage 50 mg each time, three times per day, for continuous 14 days. Another 30 healthy individuals who received physical examination our hospital served as control. Flow...
objective To investigate the clinical effects of application laparoscopic intraperitoneal onlay mesh in spigelian hernia repair. Methods Form October 2010 to December 2016, 11 patients with were repaired Minhang branch Zhongshan Hospital Fudan University. The efficacy this procedures analyzed retrospectively. Result The tension-free repairing operations performed successfully under laparoscope all cases. operative time was 30 60 minutes (mean 40 minutes), and mean blood loss 15...